Latest Research
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24 Sep
Qiaoran Xi’s group published research…
Transforming growth factor β (TGF-β) superfamily proteins are potent regulators of cellular development and differentiation. Nodal/Activin/TGF-β and BMP ligands are both present in the intra- and extracellular milieu during early development, and cross-talk between these two branches of developmental signaling is currently the subject of intense research focus.The heart is one of the earlies...
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22 Sep
Jijie Chai and collaborators publish a…
During the long-term fighting against pathogens, plants have evolved a sophisticated innate immune system to defend against infection. Plants pattern recognition receptors (PRRs) sense pathogen-associated molecular patterns (PAMPs) or host-derived danger-associated molecular patterns (DAMPs) to activate an immune response termed pattern-triggered immunity (PTI). PRRs are mainly composed of rece...
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09 Sep
Wei Xie’s group, Zi-Jiang Chen’s gro…
A joint team led by Prof. Wei Xie at Tsinghua University, Prof. Zi-Jiang Chen and Prof. Han Zhao from Shandong University, has charted the translational landscapes during the human oocyte-to-embryo transition (OET). This dataset further identified a group of homeobox TFs, including TPRXL, TPRX1, and TPRX2, which are highly translated around ZGA, and are required for proper ZGA and preimplantati...
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03 Aug
Qiaoran Xi’s group and Liwei Zhang’s…
Diffuse intrinsic pontine glioma (DIPG) is a rare and incurable pediatric brain cancer with survival of less than one year. Understanding the tumorigenesis mechanisms of DIPG and identifying potential new therapeutic strategy are major research foci in the DIPG field.On August 01, 2022, Qiaoran Xi’s research group from Tsinghua University and Liwei Zhang’s research group from Beijing Tiantan ...
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13 Jul
The transcriptional regulatory functio…
Despite the fundamental roles of TGF-β family signaling in cell fate determination in all metazoans, the mechanism by which these signals are spatially and temporally interpreted remains elusive. The cell context-dependent function of TGF-β signaling largely relies on transcriptional regulation by SMAD proteins.On July 12, 2022, Qiaoran Xi’s research group from Tsinghua University published ...
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13 Jul
A Nodal enhanced micropeptide NEMEP re…
TGF-β family proteins including Nodal are known as central regulators of early development in metazoans. For example, Nodal signaling initiates gastrulation in vivo and promotes embryonic stem cells (ESCs) to differentiate towards mesendoderm fates in vitro; these regulatory processes are mediated by the transcriptional upregulation of so-called “mesendoderm lineage determining transcription ...
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12 Jul
Jijie Chai’s research group with coll…
Crop diseases cause about loss of ~ $ 220 billion annually. Controlling of crop diseases without compromising agricultural traits has been a long-sought dream of crop breeders. A key to this end is to identify conserved and natural immune signaling molecules with a broad spectrum of pathogen resistance activity. Pathogens exude pathogenic factors known as pathogen effectors into plant cells dur...
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17 Jun
Wei Xie’s group and Lei Li’s group p…
Translation plays a key role in gene expression regulation and development. During mammalian oocyte maturation and early embryonic development, transcription is largely silenced from the full-grown oocyte until zygotic genome activation (ZGA). Therefore, during the oocyte-to-embryo transition (OET), translational regulation plays important roles in meiotic resumption, fertilization, and ZGA. Ho...
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02 Apr
Liang Ge's group discovered a novel ag…
On April 1, 2022, Liang Ge's research group at the School of Life Sciences, Tsinghua University published a research article online in the journal "Cell" titled with “CCT2 is an aggrephagy receptor for clearance of solid protein aggregates”, discovered a novel aggrephagy receptor CCT2 and its important role in the clearance of solid protein aggregates.Aggrephagy is an important way to clear i...
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23 Jan
Xinquan Wang and collaborators reveal …
SARS-CoV-2 is responsible for the ongoing global COVID-19 pandemic, posing serious threat to public health. The exact origin and zoonotic transmission route of the SARS-CoV-2 are still unknown. The Spike (S) glycoprotein of coronaviruses mediates viral entry by binding host receptor and fusing viral and cellular membranes. And the molecular evolution of sequence and structures of spike affe...