Latest Research
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30 Oct
Guangshuo Ou’s Group at the School of…
Dynamic properties are essential for microtubule (MT) physiology, which depend on the polymerization and spontaneous depolymerization of tubulin isotypes at the MT ends. Mutations in tubulin-coding genes cause human diseases collectively designated as ‘tubulinopathies’. As a result, live-cell imaging of tubulins is crucial for understanding the dynamic regulation of MTs and elucidating their ...
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30 Oct
Research groups of Wei Xie, Haifeng Wa…
In mammals, female (XX) and male (XY) cells exhibit sex chromosome dimorphism. To achieve dosage compensation of X-linked genes, female cells undergo X chromosome inactivation (XCI) during early embryo development. Abnormal XCI leads to severe developmental defects such as intellectual disabilities in humans and even embryonic lethality. Hence, investigating the mechanisms of XCI is of both sci...
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30 Oct
Xiaofeng Fang’s Group Discover a New …
Beijing, October 9, 2024 – A groundbreaking study from the laboratory of Dr. Xiaofeng Fang at School of Life Sciences, Tsinghua University, in collaboration with international partners, was published today in Nature, unveiling a novel mechanism for membrane shaping and scission in multivesicular bodies (MVBs), which play a crucial role in cellular quality control. The study, titled "Biomolecul...
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16 Jun
Wei Xie’s group from Tsinghua Univers…
The maturation of mammalian oocytes and early development is a highly complex process that requires precise spatiotemporal regulation. However, the transcriptional regulatory networks and related cis-regulatory elements involved in this process are still under extensive investigation. Enhancers are critical regulatory elements that can activate and control gene expression from distal regions. D...
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16 Jun
Bryan Wei’s Research Group at the Sch…
Natural molecular switches are ubiquitous in the biochemistry regulatory network and are critical for biological pathways. The most prominent example is the protein phosphorylation and dephosphorylation switch driven by kinases and phosphatases. In this type of switch, kinases and phosphatases perform complementary regulatory roles, leading to sophisticated up-regulation and down-regulation of ...
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16 Jun
The discovery of Pro-CRISPR factors an…
On May 29, a research paper titled "Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity" was published online in the journal Nature. The study was conducted by the research team led by associate professor Jun-Jie Gogo Liu from the School of Life Sciences at Tsinghua University, in collaboration with the teams of associate professor Chunlai Chen from Tsinghua University and...
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16 Jun
Breakthrough Study in Nature Sheds Lig…
Introduction: Opioids such as morphine and fentanyl are potent analgesics widely used in clinical practice. They alleviate pain by activating the µ-opioid receptor (µOR) in the brain. With a history dating back over 5,000 years to ancient Sumerian civilization, opioids have long been valued for their pain-relieving properties. However, the long-term use of opioids can lead to dependence, increa...
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10 Apr
Xuerui Yang's Research Team Introduces…
Cell heterogeneity is essential for the physiological functions of complex tissues under normal and disease conditions. Systematic interpretation of heterogeneous cell populations and precise identification of key cell subtypes hold substantial importance in gaining critical insights into tissue development, physiological functions, cellular interactions, and the dynamic progression of diseases...
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10 Apr
A gut-derived hormone, Cholesin, regul…
On March 18th, a research paper titled "A gut-derived hormone regulates cholesterol metabolism" was published in the journal Cell by a team led by Drs. Yiguo Wang from the School of Life Sciences at Tsinghua University and Huijie Zhang from the affiliated Nanfang Hospital of Southern Medical University. This research unveiled a novel intestinal hormone named Cholesin and elucidated its role and...
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01 Apr
Qiaoran Xi’s group and Liwei Zhang’s…
Diffuse intrinsic pontine glioma (DIPG) is the most aggressive pediatric brainstem tumor with a median survival of less than 12 months; seeking effective therapy is still the focus of the field. Nearly 80% DIPG cells harbor H3K27M mutations, which caused global reduction in H3K27me3 levels, and H3K27M are considered as driver mutations for DIPG. This understanding has recently inspired substant...