Latest Research
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19 Mar
Jijie Chai and collaborators publish …
Higher organisms have evolved the sophisticated immune system in their long-term competition with pathogenic microorganisms. The immune systems can be divided into two parts: innate immunity and adaptive immunity. The former, which is a universal and ancient form of host defense mechanism, can be initiated through perception of pathogens by a series of germline-encoded pattern recognition recep...
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01 Mar
Viral RNA structure data can be harne…
The SARS-CoV-2 virus is the causal pathogen for the worldwide COVID-19 pandemic (Perlman, 2020). To date, SARS-CoV-2 has infected more than 100 million people with more than 2.5 million deaths, causing tremendous damage to the global human society. SARS-CoV-2 is a single-stranded RNA virus, and its viral RNA is a key component in regulating host infection: the tiny SARS-CoV-2 genome (and the li...
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06 Feb
Yi Zhong’s group discovered the role …
Memory forms when a previously neutral stimulus (CS+) becomes competent to predict a biologically potent stimulus (US). But if the CS+ is repeatedly presented without the US after the memory formation, this memory will be suppressed by newly formed extinction memory. Extinction learning-induced suppression of memory has recently attracted major efforts for the development of psychiatric disorde...
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11 Jan
Xuerui Yang’s group discovered a high…
Comprehensive annotations of transcriptomes have revealed a vast number of long non-coding RNAs (lncRNAs) in various species. For the past years, extensive studies have uncovered hundreds of lncRNAs in human cells with various molecular and cellular functions. Many of these lncRNAs have been emerging as fine-tuners of key pathways related to a variety of processes, such as development and compl...
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08 Dec
Jijie Chai’s group and collaborators …
Prof. Jijie Chai’s group at School of Life Sciences, Tsinghua University, in collaboration with Prof. Jane Parker’s and Prof. Paul Schulze-Lefert’s groups from the Max Planck Institute for Plant Breeding Research, reported on the molecular mechanisms by which the plant TNL disease resistance protein RPP1 recognizes the effector protein ATR1 and assembles into an ATR1-induced resistosome to f...
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27 Nov
International study elucidates a key m…
In a paper published online in the Proceedings of the National Academy of Sciences on November 23, 2020, Jun Yao of Tsinghua University and coauthors in China and the United States reported their findings in the mechanism underlying the induction of mania in bipolar disorder (BD), which is a neuropsychiatric disorder characterized by intermittent episodes of mania and depression.The authors fir...
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29 Oct
Wei Xie’s group published research in…
Prof. Wei Xie’s group at School of Life Sciences, Tsinghua University published research in Nature on October 28, 2020, entitled “The landscape of RNA Pol II binding reveals a step-wise transition during ZGA”, revealing the activation of the zygotic genome by RNA polymerase II (Pol II) through stepwise transition. This study not only helps us to understand the fundamental mechanism underlying the onset of zygotic genome activation (ZGA), the first transcription event in life, but may also pave the way for future clinical research on early development-related diseases and assisted reproduc…
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19 Oct
Sai Li’s group at Tsinghua University…
HighlightsThe molecular architecture of the authentic SARS-CoV-2 virus is unveiled by cryo-electron tomography and subtomogram averaging.The native structures and landscape of the SARS-CoV-2 spikes revealed.The native compositions of the glycans are characterized by mass spectrometry.Structure and assembly of the SARS-CoV-2 viral RNPs are revealed in situ for the first time. All structures are ...
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28 Aug
Researchers Elucidate Molecular Mechan…
Genome stability and integrity is essential for the survival of all organisms. However, due to the endogenous metabolites and environmental agents (such as UV light or chemical exposure), DNA damage constantly happens and posts a threat. DNA glycosylase is a DNA-binding protein responsible for repairing the DNA damage. It remains a puzzle how glycosylase can efficiently and accurately recognize DNA lesions among millions and billions of normal base pairs in the genome. It has been hypothesized that glycosylase accomplishes this task by an alternating search between two diffusion modes: a hig…
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21 Jul
Wei Xie’s group and Bing Zhu’s group…
A joint team led by Dr. Wei Xie from School of Life Sciences of at Tsinghua University and Dr. Bing Zhu from Institute of Biophysics at Chinese Academy of Sciences, has revealed how the DNA methylome