Latest Research
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11 Jul
Zhucheng Chen’s group at Tsinghua Uni…
Recently, Professor Zhucheng Chen’s group at the School of Life Science reports the crystal structure of human ALC1 (amplification in liver cancer 1，also known as CHD1L：chromodomain helicase/ATPase DNA binding protein 1-like) and the cryo-EM structure bound to the nucleosome. In combination with biochemical analyses, their findings shed light on the regulation mechanisms of the enzyme, pavin...
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09 Jul
A new study elucidates an important me…
In a paper published online in the PLOS Biology on July 6, 2021, Jun Yao and coauthors of Tsinghua University reported their findings in the mechanism involving the deficits of Synaptotagmin-7-mediated activation of spontaneous NMDAR currents in bipolar disorder (BD), which is a complex neuropsychiatric disorder characterized by intermittent episodes of mania and depression.Neurotransmitter rel...
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30 Jun
Researchers discovered a Golgi-derived…
The endosome has highly dynamic motility and frequently undergoes fission and fusion events to coordinate endocytic trafficking. Endosome fission has been reported to be associated with cargo sorting. After internalization, cargoes can be segregated into distinct domains allocated for their destination, proceeding to either lysosomes for degradation, or the plasma membrane or trans-Golgi networ...
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03 Jun
Mitocytosis, a migrasome-mediated mito…
As vital organelles for eukaryotic cells, mitochondria are subject to tight quality control. Various mechanisms, including mitochondrial proteases, proteasome-mediated degradation of outer mitochondrial membrane (OMM) proteins, degradation of mitochondrial-derived vesicles (MDVs), and mitophagy have been shown play important roles in mitochondrial quality control.On 27th May of 2021, Professor ...
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19 Mar
Jijie Chai and collaborators publish …
Higher organisms have evolved the sophisticated immune system in their long-term competition with pathogenic microorganisms. The immune systems can be divided into two parts: innate immunity and adaptive immunity. The former, which is a universal and ancient form of host defense mechanism, can be initiated through perception of pathogens by a series of germline-encoded pattern recognition recep...
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01 Mar
Viral RNA structure data can be harne…
The SARS-CoV-2 virus is the causal pathogen for the worldwide COVID-19 pandemic (Perlman, 2020). To date, SARS-CoV-2 has infected more than 100 million people with more than 2.5 million deaths, causing tremendous damage to the global human society. SARS-CoV-2 is a single-stranded RNA virus, and its viral RNA is a key component in regulating host infection: the tiny SARS-CoV-2 genome (and the li...
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06 Feb
Yi Zhong’s group discovered the role …
Memory forms when a previously neutral stimulus (CS+) becomes competent to predict a biologically potent stimulus (US). But if the CS+ is repeatedly presented without the US after the memory formation, this memory will be suppressed by newly formed extinction memory. Extinction learning-induced suppression of memory has recently attracted major efforts for the development of psychiatric disorde...
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11 Jan
Xuerui Yang’s group discovered a high…
Comprehensive annotations of transcriptomes have revealed a vast number of long non-coding RNAs (lncRNAs) in various species. For the past years, extensive studies have uncovered hundreds of lncRNAs in human cells with various molecular and cellular functions. Many of these lncRNAs have been emerging as fine-tuners of key pathways related to a variety of processes, such as development and compl...
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08 Dec
Jijie Chai’s group and collaborators …
Prof. Jijie Chai’s group at School of Life Sciences, Tsinghua University, in collaboration with Prof. Jane Parker’s and Prof. Paul Schulze-Lefert’s groups from the Max Planck Institute for Plant Breeding Research, reported on the molecular mechanisms by which the plant TNL disease resistance protein RPP1 recognizes the effector protein ATR1 and assembles into an ATR1-induced resistosome to f...
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27 Nov
International study elucidates a key m…
In a paper published online in the Proceedings of the National Academy of Sciences on November 23, 2020, Jun Yao of Tsinghua University and coauthors in China and the United States reported their findings in the mechanism underlying the induction of mania in bipolar disorder (BD), which is a neuropsychiatric disorder characterized by intermittent episodes of mania and depression.The authors fir...