方晓峰 博士

助理教授,博士生导师


2005 – 2009     西北农林科技大学 理学学士

2009 – 2015     北京协和医学院 & 北京生命科学研究所 博士

2015 – 2017     清华大学, 博士后

2017 – 2020     英国John Innes Centre 玛丽居里学者,博士后

2020 – 至今     清华大学生命科学学院, 助理教授/研究员

 

●  研究兴趣、领域:


实验室将主要以拟南芥为模式生物,综合利用遗传学、生物化学、生物信息学、活体成像等手段研究:1. RNA和蛋白质通过相分离形成的无膜细胞器的组装机制及其在植物体生长发育和响应胁迫过程中的作用机制。2. RNA 3’末端加工的机制及其在植物体生长发育过程中的作用。

 

●  代表性论文:


Fang X*, Wu Z, Raitskin O, Webb K, Voigt P, Lu T, Howard M, Dean C (2020) The 3' processing of antisense RNAs physically links to chromatin-based transcriptional control. PNAS. 117(26):15316-15321. (*co-corresponding author).

Yang M#, Woolfenden HC#, Zhang Y#, Fang X#, Liu Q, Vigh ML, Cheema J, Yang X, Norris M, Yu S, Carbonell A, Brodersen P, Wang J, & Ding Y (2020) Intact RNA structurome reveals mRNA structure-mediated regulation of miRNA cleavage in vivo.Nucleic Acids Resgkaa577. (#co-first author)

Wu Z, Fang X, Zhu D, Dean C (2020) Autonomous pathway: FLOWERING LOCUS C repression through an antisense-mediated chromatin-silencing mechanism. Plant Physiol. 182(1):27-37.

Bloomer RH, Hutchison CE, Bäurle I, Walker J, Fang X, Perera P, Velanis CN, Gümüs S, Spanos C, Rappsilber J, Feng X, Goodrich J, Dean C (2020) The Arabidopsis epigenetic regulator ICU11 as an accessory protein of Polycomb Repressive Complex 2. PNAS. 117(28):16660-16666.

Fang X#, Wang L#, Ishikawa R#, Li Y, Fiedler M, Liu F, Calder G, Rowan B, Weigel D, Li P, Dean C. (2019) Arabidopsis FLL2 promotes liquid-liquid phase separation of polyadenylation complexes. Nature. 569(7755): 265-269 (#co-first author)

Fang X#, Zhao G#, Zhang S, Li Y, Gu H, Li Y, Zhao Q, Qi Y (2018) Chloroplast-to-nucleus signaling regulates microRNA biogenesis in Arabidopsis.Developmental Cell,48, 371-382. (#co-first author)

Li Y#, Yuan Y#, Fang X#, Lu X, Lian B, Zhao G, Qi Y (2018) A role for MINIYO and QUATRE-QUART2 in the assembly of RNA polymerases II, IV, and V in Arabidopsis. Plant Cell. 30, 466-480. (#co-first author)

Cui Y#, Fang X#, and Qi Y (2016) TRANSPORTIN1 promotes the association of microRNAs with ARGONAUTE1 in Arabidopsis. Plant Cell. 28, 2576-2585. (#co-first author)

Fang X#, and Qi Y (2016) RNAi in plants: an Argonaute-centered view.Plant Cell. 28, 272-285.

Fang X#, Cui Y, Li Y, and Qi Y (2015) Transcription and processing of primary microRNAs are coupled by Elongator complex in Arabidopsis.Nature Plants. 1, 15075. (Highlighted in the same issue of Nature Plants).

Fang X#, Shi Y#, Lu X, Chen Z, Qi Y (2015) CMA33/XCT regulates small RNA production through modulating the transcription of Dicer-Like genes in Arabidopsis.Molecular Plant. 8, 1227-1236. (#co-first author)

 

 

●  联系方式:


地址:清华大学生物技术馆4段214室(办公室)

电子邮件:xffang@mail.tsinghua.edu.cn