方晓峰 博士

副教授

2005 - 2009 西北农林科技大学 理学学士

2009 - 2015 北京协和医学院 & 北京生命科学研究所 博士

2015 - 2017 清华大学 博士后

2017 - 2020 英国John Innes Centre 玛丽居里学者，博士后

2020 - 至今 清华大学生命科学学院, 助理教授、副教授

 

●  研究兴趣、领域：

生物大分子（如RNA与蛋白质）能够通过液-液相分离在细胞中形成分子凝聚体，广泛地参与不同生物学过程，这使得相分离成为目前生物学领域最前沿的研究之一。相分离这一机制不仅更新了我们对许多生物学问题的理解，也为我们研究生物学问题提供了新的思路。

实验室综合利用遗传学、生物化学、生物信息学、细胞生物学等手段研究相分离在植物生长发育和应对胁迫过程中的作用及机制。

 

●  代表性论文：

1. Wang Y, He S*, Fang X*. (2023) Emerging roles of phase separation in plant transcription and chromatin organization. Current Opinion in Plant Biology 75:102387.

2. Zhang H^#, Peng F^#, He C^#, Liu Y^#, Deng H*, Fang X*. (2023) Large-scale identification of potential phase separation proteins from plants using a cell-free system. Molecular Plant 16(2):310-313.

3. Wang B^#, Zhang H^#, Huai J^#, Peng F, Wu J, Lin R*, Fang X*. (2022) Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis. Nature Chemical Biology. 18(12):1361-1369.

4. Lin Y*, Fang X*. (2021) Phase Separation in RNA Biology. J Genet Genomics. 48(10):872-880 (Invited Review)

5. Li C, Fang X*. (2020) Phase Separation as a Molecular Thermosensor. Developmental Cell. 55(2):118-119.

6. Fang X*, Wu Z, Raitskin O, Webb K, Voigt P, Lu T, Howard M, Dean C (2020) The 3' processing of antisense RNAs physically links to chromatin-based transcriptional control. PNAS. 117(26):15316-15321.

7. Fang X^#, Wang L^#, Ishikawa R^#, Li Y, Fiedler M, Liu F, Calder G, Rowan B, Weigel D, Li P, Dean C. (2019) Arabidopsis FLL2 promotes liquid-liquid phase separation of polyadenylation complexes. Nature. 569(7755): 265-269.

8. Fang X^#, Zhao G^#, Zhang S, Li Y, Gu H, Li Y, Zhao Q, Qi Y (2018) Chloroplast-to-nucleus signaling regulates microRNA biogenesis in Arabidopsis. Developmental Cell. 48, 371-382.

9. Li Y^#, Yuan Y^#, Fang X^#, Lu X, Lian B, Zhao G, Qi Y (2018) A role for MINIYO and QUATRE-QUART2 in the assembly of RNA polymerases II, IV, and V in Arabidopsis.Plant Cell. 30, 466-480.

10. Cui Y^#, Fang X^#, and Qi Y (2016) TRANSPORTIN1 promotes the association of microRNAs with ARGONAUTE1 in Arabidopsis. Plant Cell. 28, 2576-2585.

11. Fang X, and Qi Y (2016) RNAi in plants: an Argonaute-centered view. Plant Cell. 28, 272-285.

12. Fang X, Cui Y, Li Y, and Qi Y (2015) Transcription and processing of primary microRNAs are coupled by Elongator complex in Arabidopsis. Nature Plants. 1, 15075.

13. Fang X^#, Shi Y^#, Lu X, Chen Z, Qi Y (2015) CMA33/XCT regulates small RNA production through modulating the transcription of Dicer-Like genes in Arabidopsis. Molecular Plant. 8, 1227-1236.

●  联系方式：

电子邮件：xffang@mail.tsinghua.edu.cn

实验室主页：http://fanglab.life.tsinghua.edu.cn/

地址：清华大学生物技术馆4段214室

电话：010-62781942