邓海腾  博士

教授,博导


1985    武汉大学   学士     
1988    武汉大学    硕士     
1996    Pennsylvania State University      博士
University of Alberta                    博士后
Oak Ridge National Laboratory    博士后
1/2000-12/2001 讲师,发育生物学系,爱因斯坦医学院
12/2001-7/2003 助理教授,医学系,爱因斯坦医学院
8/2003-12/2003 助理教授,内布拉斯加大学
1/2004-7/2009   研究助理教授,洛克菲勒大学
9/2009-2/2011   研究副教授和蛋白质组中心主任,洛克菲勒大学
9/2008-Present  客座研究员,纽约大学
3/2011-Present  客座教授,洛克菲勒大学
3/2011-Present  教授,清华大学

 

●  研究兴趣、领域:


发展和应用蛋白质组学、代谢组学和化学生物学的技术和方法。研究氧化还原生物学在衰老和疾病中的功能和作用机制。开发提高健康寿命的策略。研究病原微生物-宿主细胞的相互作用。 发现和鉴别癌症早期诊断的标记物并研究蛋白质药物的修饰和作用机制。

●  代表性论文:


1. Zhang, Lin; Shen, Hao; Gong, Yiyi; Pang, Xiaojing; Yi, Meiqi; Guo, Lin; Li, Jin; Arroyo, Sam; Lu, Xin; Ovchinnikov, Sergey; Cheng, Gong; Liu, Xudong; Jiang, Xu; Feng, Shan; Deng, Haiteng; Development of a dual-functional conjugate of antigenic peptide and Fc-III mimetics (DCAF) for targeted antibody blocking, Chemical Science, 2019, 10(11): 3271-3280.
2. Teng, Ruifang; Liu, Zhilei; Tang, Haiping; Zhang, Wenhao; Chen, Yuling; Xu, Rrenhua; Chen, Liang; Song, Jiangping; Liu, Xiaohui; Deng, Haiteng; HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells, Redox Biology, 2019, 24: 101218.
3. Chen P, Wang H, Zhang W, Chen Y, Lv Y, Wu D, Guo M Sr, Deng H.,Loss of BAP1 Results in Growth Inhibition and Enhances Mesenchymal-Epithelial Transition in Kidney Tumor Cells. Molecular Cell Proteomics. 2019 Jul;18(7):1320-1329.
4. Tang H, Teng R, Zhao X, Wang X, Xu L, Deng H*, Liu X*. Isotope tracing assisted metabolic profiling: Application to understanding HSP60 silencing mediated tumor progression. Anal Chim Acta. 2019 Jan 24;1047:93-103.
5. Wang, Weixuan; Hu, Yadong; Wang, Xiaofei; Wang, Qingtao; Deng, Haiteng*; ROS-mediated 15-Hydroxyprostaglandin Dehydrogenase Degradation via Cysteine Oxidation Promotes NAD+-Mediated Epithelial-Mesenchymal Transition, Cell Chemical Biology, 2018, 25: 1-7.
6. Wang, Weixuan; Hu, Yadong; Yang, Changmei; Zhu, Songbiao; Wang, Xiaofei; Zhang, Zhenyu; Deng, Haiteng*; Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition, Molecular Cell Proteomics, 2018, 17(10): 2005-2017.
5. Liu Yan; Yang Fan; Li Siying; Dai Junbiao*; Deng Haiteng*; Glutaredoxin Deletion Shortens Chronological Life Span in Saccharomyces cerevisiae via ROS-Mediated Ras/PKA Activation, Journal of Proteome Research, 2018, 17(7): 2318-2327.
6. Fan Yang, Meiqi Yi, Yan Liu, Qingtao Wang, Yadong Hu, Haiting Deng, Glutaredoxin-1 silencing induces cell senescence via p53/p21/p16 signaling axis, Journal of Proteome Research. 2018 Mar 2;17(3):1091-1100. 
7. Liu H, Li S, Liu X, Chen Y, Deng H.,SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis. J Proteome Res. 2018 Sep 7;17(9):3143-3152.     
8. Liu, Z. L.; Hu, Y. D.; Wang, H. L.; Liu, C. D.; Wang, Q. T.; Deng, H. T.* Hydrogen peroxide mediated mitochondrial UNG1-PRDX3 interaction and UNG1 degradation. Free Radic Biol Med 2016, 99, 54-62.
9. Gong, Y.; Zhang, L.; Li, J.; Feng, S.; Deng, H.* Development of the Double Cyclic Peptide Ligand for Antibody Purification and Protein Detection. Bioconjug Chem 2016, 27 (7), 1569-73.
10. Tang, H.; Chen, Y.; Liu, X.; Wang, S.; Lv, Y.; Wu, D.; Wang, Q.; Luo, M.; Deng, H.* Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma. Oncotarget 2016 Jun 21;7(25):38822-38834.
11. Jiang, X.; Feng, S.; Chen, Y.; Feng, Y.; Deng, H.* Proteomic analysis of mTOR inhibition-mediated phosphorylation changes in ribosomal proteins and eukaryotic translation initiation factors. Protein Cell 2016, 7 (7), 533-7.
12. Wang, X.; Tang, H.; Chen, Y.; Chi, B.; Wang, S.; Lv, Y.; Wu, D.; Ge, R.; Deng, H.* Overexpression of SIRT3 disrupts mitochondrial proteostasis and cell cycle progression. Protein Cell 2016, 7 (4), 295-9.
13. Gu L, Chen Y, Wang QT, Li X, Mi K, Deng H. *, Functional Characterization of Sirtuin-like Protein in Mycobacterium smegmatis. J Proteome Res. 2015;14(11):4441-9.
14. Feng S, Chen Y, Yang F, Zhang L, Gong Y, Adilijiang G, Gao Y, Deng H*. Development of a Clickable Probe for Profiling of Protein Glutathionylation in the Central Cellular Metabolism of E. coli and Drosophila. Cell Chem Biol. 2015 Nov 19;22(11):1461-9.
15. Lixu Jin, Zhiguo Zheng, Xiaoyong Jiang, Yi Huo, Haiyun Deng, Yuling Chen, Qingquan Lian, Renshan Ge, Haiteng Deng*, Down-regulation of Rab 5C-dependent Endocytosis and Glycolysis in Cisplatin-resistant Ovarian Cancer Cell Lines, Molecular and Cellular Proteomics, 2014, Nov;13(11):3138-51.
16. Yadong Hu, Helin Wang, Renhua Xu, Qingtao Wang, Haiteng Deng*, NAD-Mediated Protein Expression, Cell Proliferation, and Responses to Oxidative Stress, Journal of Proteome Research, 2014 Feb 7; 13(2):786-95.     
17. Shan Feng, Lei Zhang, Gulishana Adilijiang, Jieyuan Liu, Haiteng Deng*, Substrate Profiling of Glutathione S-transferase with Engineered Enzymes and Matched Glutathione Analogues, Angew Chem Int Ed Engl. 2014 Jul 7;53(28):7149-53.
丛书章节
1. 邓海腾,陈宇凌,陈香梅,《蛋白质组学与精准医学》,2018,国家出版社
2. J-R Zhang, MG Marinus, H Deng, Methylation and other Modifications of Nucleic Acids and Proteins, Reference Module in Biomedical Sciences, 2015 Elsevier Inc.
3. Amanda Chen, Haiqiang Yu, Haiteng Deng and W. Beau Mitchell, Mechanisms of αIIbβ3 Biogenesis in the Megakaryocyte: A Proteomics Approach in Hematology - Science and Practice, Edited by Charles H. Lawrie, ISBN 978-953-51-0174-1, Publisher: InTech, March 02, 2012 DOI: 10.5772/2259.
4. Haiteng Deng, Proteomics in Drug Discovery in Handbook of Drug Screening, R. Seethala, Eds, Informa Healthcare, May 2009.
5. Denis L. Rousseau, David Li, Eric Y. Hayden, Haiteng Deng and Syun-Ru Yeh, Protein-ligand interactions in mammalian nitric oxide synthase, in THE SMALLEST BIOMOLECULES: DIATOMICS AND THEIR INTERACTIONS WITH HEME PROTEINS, Abhik Ghosh, Eds, Elsevier, Dec 2007.

●  荣誉、奖励及参加学术团体的情况:


会员
The New York Academy of Science; The American Chemical Society; The American Society for Mass Spectrometry

●  联系方式:


北京市海淀区清华大学生命科学学院 100084
电话:+86-10-62789415
邮箱:dht@mail.tsinghua.edu.cn