鲁志 博士

研究员,博士生导师


2017-至今 清华大学 生命科学学院 研究员(tenured),博导

2011-2016 清华大学 生命科学学院  特别研究员,博导

2008-2011 耶鲁大学 生物信息学 博士后

2003-2008  罗切斯特大学 生物物理学 博士

1998-2003  中国科学技术大学  生命科学学院 学士

●  研究兴趣、领域:


我们实验室致力于发展生物信息学技术,并探索能够广泛应用于基因组学和癌症生物学的医学实践。我们利用高通量测序,结合机器学习和人工智能技术,来研究遗传信息是如何被编码在结构化的DNA和RNA分子之中,以及它们是如何在一个生命体系中相互作用、彼此调控。
我们的使命,是帮助人们更早期的发现癌症,因为“上工治未病”。我们相信,这种使命感以及为此付出的实践和努力,将帮助我们理解和治疗人类疾病,并最终认识和提高我们自己。
我们希望把生物信息技术运用到重要的生物和医学问题中,实验室的科研项目主要包括三个方向: 
1.        [RNA调控]:编码和非编码RNA的转录后调控研究  
2.        [精准医疗]:癌症等疾病中新型RNA分子标识物的发现和机理研究
3.        [人工智能]:机器学习等数据挖掘技术的研究及其在基因组学大数据上的应用

●  代表性论文:


 ? Shuaishuai Teng1, Yang Eric Li1, Ming Yang, Rui Qi, Yiming Huang, Qianyu Wang, Yanmei Zhang, Shanwen Chen, Shasha Li, Kequan Lin, Yang Cao, Qunsheng Ji, Qingyang Gu, Yujing Cheng, Zai Chang, Wei Guo, Pengyuan Wang, Ivan Garcia-Bassets, Zhi John Lu* and Dong Wang* (2020) Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer. Cell Research 30(1):34-49 (1contributed equally, *co-corresponding authors)(IF:18)
? Chang Tan1, Jingyi Cao1, Lu Chen1, Xiaochen Xi, Siqi Wang, Yumin Zhu, Liuqing Yang, Longteng Ma, Dong Wang, Jianhua Yin*, Ti Zhang* and Zhi John Lu* (2019) Noncoding RNAs serve as diagnosis and prognosis biomarkers for hepatocellular carcinoma Clinical Chemistry 65:7 (1 contributed equally, * co-corresponding) (IF: 8)
?  Yang Yang1, Lei Chen1, Jin Gu1, Hanshuo Zhang1, Jiapei Yuan, Qiuyu Lian, Guishuai Lv, Siqi Wang, Yang Wu, Yu-Cheng T. Yang, Dongfang Wang, Yang Liu, Jing Tang, Guijuan Luo, Yang Li, Long Hu, Xinbao Sun, Dong Wang, Mingzhou Guo, Qiaoran Xi, Jianzhong Xi, Hongyang Wang*, Michael Q. Zhang* and Zhi John Lu* (2017) Recurrently deregulated lncRNAs in hepatocellular carcinoma. Nature Communications 8, 14421 (1contributed equally) (IF: 12)
?  Yang Eric Li1, Mu Xiao1, Binbin Shi1, Yu-Cheng T. Yang, Dong Wang, Fei Wang, Marco Marcia and Zhi John Lu* (2017) Identification of high-confidence RNA regulatory elements by combinatorial classification of RNA-protein binding sites. Genome Biology 18:169 (1contributed equally) (IF: 14)
?  Boqin Hu1, Yu-Cheng T. Yang1, Yiming Huang, Yumin Zhu and Zhi John Lu* (2017) POSTAR: a platform of post-transcriptional regulation coordinated by RNA binding proteins. Nucleic Acids Research 45 (D1): D104-D114 (1contributed equally) (IF: 11)
? Long Hu, Zhiyu Xu, Boqin Hu and Zhi John Lu* (2017) COME: a robust coding potential calculator for lncRNA identification and characterization based on multiple features. Nucleic Acids Research 45 (1): e2  (IF: 11)
代表性合作
? Rui Xiao, Jia-Yu Chen, Zhengyu Liang, Daji Luo, Geng Chen, Zhi John Lu, Yang Chen, Bing Zhou, Hairi Li, Xian Du, Yang Yang, Mingkui San, Xintao Wei, Wen Liu, Eric Lecuyer, Brenton R. Graveley, Gene W. Yeo, Christopher B. Burge, Michael Q. Zhang, Yu Zhou and Xiang-Dong Fu (2019) Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription. Cell 178, 107–121
?  Sai Luo, J. Yuyang Lu, Lichao Liu, Yafei Yin, Chunyan Chen, Xue Han, Bohou Wu, Ronggang Xu, Wei Liu, Pixi Yan, Wen Shao, Zhi Lu, Haitao Li, Jie Na, Fuchou Tang, Jianlong Wang, Yong E. Zhang, Xiaohua Shen (2016) Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent Cells. Cell Stem Cell 18, 1–16
? Gerstein MB, Joel Rozowsky, Koon-Kiu Yan, …, Lu Z, …, Robert Waterston (2014) Comparative Analysis of the Transcriptome across Distant Species. Nature 512(7515):445-448.
? ENCODE Project Consortium#. (2012) An Integrated Encyclopedia of DNA Elements in the Human Genome. Nature 489, 57–74. (#Lu Z is part of ENCODE Consortium) [Cover Story]
?  Gerstein MB 1*, Lu ZJ1, Van Nostrand EL1, Cheng C1, Arshinoff BI1, et al. (2010) Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science 330(6012): 1775-1787 (120 co-first authors, *15 co-corresponding authors, ~150 authors in total) [Cover Story]

●  荣誉、奖励及参加学术团体的情况:


“优秀青年”基金获得者, “霍英东”青年基金获得者, “新世纪人才计划”获得者  

●  联系方式:


清华大学 生命科学学院,生物信息学“教育部重点实验室”, 北京,中国,100084
Tel. /FAX: +86-10-62789217 
E-mail: lulab1 AT tsinghua.edu.cn
实验室主页: http://lulab.life.tsinghua.edu.cn