王宏伟 博士

院长,教授,博士生导师


1992-1996 清华大学生物科学与技术系,学士
1996-2001 清华大学生物科学与技术系,博士
2001-2006 美国劳伦斯伯克利国家实验室生命科学部,博士后
2006-2008 美国劳伦斯伯克利国家实验室生命科学部,研究科学家
2009-2011 美国耶鲁大学分子生物物理与生物化学系,Tenure-Track助理教授
2010.12-至今 清华大学生命科学学院,教授、博导
2016.04-至今 清华大学生命科学学院院长

●  研究兴趣、领域:


利用冷冻电子显微学研究生物大分子复合体的结构与分子机理。主要研究方向如下:
1. 更高效、更高分辨率的冷冻电镜方法学开发;
2. 细胞骨架和生物膜系统的协调机制;
3. 核酸质量控制的分子机制和调控。

●  代表性论文:


1. Jin W, Wang J, Liu CP, Wang HW*, Xu RM*. (2020) Structural Basis for pri-miRNA Recognition by Drosha. Mol. Cell, doi: 10.1016/j.molcel.2020.02.024. [Epub ahead of print]
2. Zheng L, Chen Y, Li N, Zhang J, Liu N, Liu J, Dang W, Deng B, Li Y, Gao X, Tan C, Yang Z, Xu S, Wang M, Yang H, Sun L, Cui Y, Wei X, Gao P*, Wang HW*, Peng H*. (2020) Robust ultraclean atomically thin membranes for atomic-resolution electron microscopy. Nat. Commun., 11(1):541.
3. Fan X, Wang J, Zhang X, Yang Z, Zhang JC, Zhao L, Peng HL, Lei J*, Wang HW*. (2019) Single particle cryo-EM reconstruction of 52 kDa streptavidin at 3.2 Angstrom resolution. Nat. Commun., 10(1):2386.
4. Wang J, Wang J, Hu M, Wu S, Qi J, Wang G, Han Z, Qi Y, Gao N, Wang HW*, Zhou JM*, Chai J*. (2019) Ligand-triggered allosteric ADP release primes a plant NLR complex. Science, 364(6435). pii: eaav5868.
5. Wang J, Hu M, Wang J, Qi J, Han Z, Wang G, Qi Y, Wang HW*, Zhou JM*, Chai J*. (2019) Reconstitution and structure of a plant NLR resistosome conferring immunity. Science, 364(6435). pii: eaav5870.
6. Liu N, Zhang J, Chen Y*, Liu C, Zhang X, Xu K, Wen J, Luo Z, Chen S, Gao P, Jia K, Liu Z, Peng H*, Wang HW*. (2019) Bioactive Functionalized Monolayer Graphene for High-Resolution Cryo-Electron Microscopy. J. Am. Chem. Soc., 141(9):4016-4025.
7. Liu Z, Wang J, Cheng H, Ke X, Sun L, Zhang Q, Wang HW*. (2018) Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate. Cell, 173(5):1191-1203
8. Mei K, Li Y, Wang S, Shao G, Wang J, Ding Y, Luo G, Yue P, Liu JJ, Wang X, Dong MQ, Wang HW*, Guo W*. (2018) Cryo-EM structure of the exocyst complex. Nat. Struct. Mol. Biol., 25(2):139-146 (Cover)
9. Fan X, Zhao L, Liu C, Zhang JC, Fan K, Yan X, Peng HL, Lei J*, Wang HW*. (2017) Near-Atomic Resolution Structure Determination in Over-Focus with Volta Phase Plate by Cs-Corrected Cryo-EM. Structure, 25(10):1623-1630
10. Xu J, Zhao L, Xu Y, Zhao W, Sung P*, Wang HW*. (2017) Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange. Nat. Struct. Mol. Biol., 24(1):40-46

●  荣誉、奖励及参加学术团体的情况:


国家杰出青年基金获得者
谈家桢生命科学创新奖获得者
科学探索奖获得者

●  联系方式:


电话:+86-10-62772390 (office)
+86-10-62798651 (lab)
E-mail: hongweiwang@tsinghua.edu.cn
Lab website: http://cryoem.life.tsinghua.edu.cn/