江鹏 博士

研究员,助理教授


1999-2003年  安徽大学生物技术系 学士
2003-2008年  中国科学技术大学分子细胞生物学系 博士
2008-2013年  美国宾夕法尼亚大学医学院 博士后
2013-2014年  美国宾夕法尼亚大学医学院 Research Associate
2014-         清华大学生命科学学院 研究员

●  研究兴趣、领域:


1)探寻肿瘤细胞中发生异常的代谢通路,并深入研究其中的调控机制及其对肿瘤细胞命运的影响;
2)肿瘤细胞感知环境中营养及代谢物质改变的分子机制和生理功能。

 

●  代表性论文:


Deng L, Yao P, Li L, Ji F, Zhao S, Xu C, Lan X, Jiang P*. p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival. Nature Communications, (2020) 11, 1755-18; doi:10.1038/s41467-020-15573-6

Li L, Mao Y, Zhao L, Li L, Wu J, Zhao M, Du W, Yu L, Jiang P*. p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis. Nature. (2019) 567(7747):253-256.

Li L#, Li L#, Li W, Chen T, Bin Zou, Zhao L, Wang H, Wang X, Xu L, Liu X, Wang D, Li B, Mak TW, Du W*, Yang X*, Jiang P*. TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation. Nature Communications. (2018), Nov 8; 9(1):4683.

Yao P, Sun H, Xu C, Chen T, Zou B, Jiang P*, Du W*. Evidence for a direct cross-talk between malic enzyme and the pentose phosphate pathway via structural interactions. J Biol Chem. (2017) Oct 13; 292(41):17113-17120.

Jiang P, Du W and Yang X*. Critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation. Cell Cycle. (2013), 12(24): 3720-3726.

Du W#, Jiang P#, Mancuso A, Stonestrom A, Brewer M, Minn AJ, Mak TW, Wu M* and Yang X*. TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nature Cell Biology. (2013), Aug. 15, 991–1000.

Jiang P#, Du W#, Mancuso A, Wellen KE, Yang X*. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature. (2013), Jan. 493: 689-693. 

Jiang P#, Du W#, Wang X, Mancuso A, Gao X, Wu M* and Yang X*. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nature Cell Biology. (2011) Mar.13: 310-316.


●  联系方式:


Email: jiang-lab@mail.tsinghua.edu.cn
Phone:010-62786079 (Office), or 010-62783063 (Laboratory)