吴畏 博士

教授, 博士生导师


1987-1991,四川大学,获学士学位  
1991-1994,四川大学,获硕士学位
1994-1996,中国科学院微生物研究所,实习研究员
1996-2001,德国海德堡大学,获博士学位
2001-2005 ,  德国癌症研究中心,博士后
2005-现在 ,   清华大学教授

 

●  研究兴趣、领域:


成体干细胞通过增殖和分化维持组织稳态,积累肿瘤驱动突变后,可能导致肿瘤的发生。我们利用小鼠和体外类器官(organoid)培养技术,结合基因组编辑和化学生物学手段,研究肠干细胞分化以及癌变的表观遗传调控机制及其干预位点和干预手段。

●  代表性论文:


1. Su S, Yang Z, Gao H, Yang H, Zhu S, An Z, Wang J, Li Q, Chandarlapaty S, Deng H, Wu W*, Rao Y*. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582.
2. An Z, Lv W, Su S, Wu W*, Rao Y*. Developing potent PROTACs tools for selective degradation of HDAC6 protein. Protein Cell. 2019 Jan 2.
3. Zhu G, Fan Z, Ding M, Zhang H, Mu L, Ding Y, Zhang Y, Jia B, Chen L, Chang Z, Wu W. An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis. Oncogene. 2015 Mar 9.
4. Ding Y, Su S, Tang W, Zhang X, Chen S, Zhu G, Liang J, Wei W, Guo Y, Liu L, Chen YG, Wu W. Enrichment of the β-catenin-TCF complex at the S and G2 phases ensures cell survival and cell cycle progression. J Cell Sci. 2014 Nov 15;127(22):4833-45.
5. Zhu G, Fan Z, Ding M, Mu L, Liang J, Ding Y, Fu Y, Huang B, Wu W. DNA Damage Induces the Accumulation of Tiam1 by Blocking β-TrCP-dependent Degradation. J Biol Chem. 2014 May 30;289(22):15482-15494.
6. Su X, Zhu G, Ding X, Lee SY, Dou Y, Zhu B, Wu W#, and Li H#. Molecular basis underlyinghistone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1. Genes Dev. 2014 Mar 15;28(6):622-36. (#: co-corresponding author) (Featured by F1000)
7. Fu Y, Huang B, Shi Z, Han J, Wang Y, Huangfu J, Wu W. SRSF1 and SRSF9 RNA binding proteins promote Wnt signaling-mediated tumorigenesis by enhancing β-catenin biosynthesis. EMBO Mol Med. 2013 May;5(5):737-50.
8. Zhu G, Wang Y, Huang B, Liang J, Ding Y, Xu A, Wu W. A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells. Oncogene. 2012 Feb 23;31(8):1001-12.
9. Liang J, Fu Y, Cruciat CM, Jia S, Wang Y, Tong Z, Tao Q, Ingelfinger D, Boutros M, Meng A, Niehrs C, Wu W. Transmembrane Protein 198 Promotes LRP6 Phosphorylation and Wnt Signaling Activation. Mol Cell Biol. 2011 Jul;31(13):2577-90.
10. Chai G, Ma C, Bao K, Zheng L, Wang X, Sun Z, Salo E, Adell T, Wu W. Complete functional segregation of planarian beta-catenin-1 and -2 in mediating Wnt signaling and cell adhesion. J Biol Chem. 2010 Jul 30;285(31):24120-30.
11. Wang Y, Fu Y, Gao L, Zhu G, Liang J, Gao C, Huang B, Fenger U, Niehrs C, Chen YG, Wu W. Xenopus skip modulates Wnt/beta-catenin signaling and functions in neural crest induction. J Biol Chem. 2010 Apr 2;285(14):10890-901.
12. *Davidson G, *Wu W, Shen J, Bilic J, Fenger U, Stannek P, Glinka A, Niehrs C. Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature. 2005 Dec 8;438(7069):867-72. (*equal contribution)
13. Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W. Rspo2 is a secreted activator of Wnt/β-catenin signalling and is required for Xenopus myogenesis. Dev Cell. 2004 Oct; 7(4): 525-34.
14. *Mao B, *Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature. 2001 May 17; 411(6835):321-5. (*equal contribution)

●  联系方式:


清华大学生命科学学院,100084, 北京

电话:010-62797127,         

E-mail:wwu(at)tsinghua.edu.cn