俞立 博士

教授

1990-1994 四川大学 学士

1994-1997 云南大学 硕士

1997-2000 北京大学 博士

2000-2008 美国国立卫生研究院 博士后

2008-至今 清华大学生命科学学院 教授，博士生导师

●  研究兴趣、领域：

综合细胞生物学，遗传学，生物化学，分子生物学等研究方法，以不同模式生物为模型研究俞立实验室发现的新细胞器迁移体（Migrasome）的机制与功能。

●  代表性论文：

1. Haisha Liang, Xinyu Ma, Yuanyuan Zhang, Yuheng Liu, Nan Liu, Weiying Zhang, Jianhui Chen, Boqi Liu, Wanqing Du, Xiaohui Liu and Li Yu*. The formation of migrasomes is initiated by the assembly of sphingomyelin synthase 2 foci at the leading edge of migrating cells. Nat Cell Biol. 2023 Aug; 25(8), 1173-1184.

2. Tianlun Ding, Jinyao Ji, Weiying Zhang, Yuheng Liu, Boqi Liu, Yiyang Han, Chunlai Chen, Li Yu*. The phosphatidylinositol (4,5)-bisphosphate-Rab35 axis regulates migrasome formation. Cell Res. 2023 Aug;33(8),617-627.

3. Cuifang Zhang, Tianqi Li, Shuyao Yin, Mingyi Gao, Helen He, Ying Li, Dong Jiang, Minghui Shi, Jianbin Wang and Li Yu. Monocytes deposit migrasosomes to promote embryonic angigogenesis, Nat Cell Biol. 2022. Nat Cell Biol. 2022 Dec; 24(12), 1726-1738.

4. Yizheng Wang#, Shuaixin Gao, Yuheng Liu, Dongju Wang, Boqi Liu, Dong Jiang, Catherine C. L. Wong, Yang Chen, Li Yu*. Retractosomes: small extracellular vesicles generated from broken-off retraction fibers. Cell Res. 2022 May;0,1-4.

5. Yuwei Huang#, Xing Zhang, Hong-Wei Wang, Li Yu*. Assembly of Tetraspanin-enriched macrodomains contains membrane damage to facilitate repair. Nat Cell Biol. 2022 June; 24, 825-832.

6. Haifeng Jiao#, Dong Jiang#, Xiaoyu Hu, Wanqing Du, Liangliang Ji, Yuzhuo Yang, Xiaopeng Li, Takami Sho, Xuan Wang, Ying Li, Yu-Ting Wu, Yau-Huei Wei, Xiaoyu Hu, and Li Yu*. Mitocytosis, a migrasome-mediated mitochondrial quality-control process. Cell. 2021 May27; 184,2896-2910.

7. Jiamin Wu#, Zhi Lu#, Dong Jiang#, Yuduo Guo, Hui Qiao, Yi Zhang, Tianyi Zhu,Yeyi Cai, Xu Zhang, Karl Zhanghao, Hao Xie, Tao Yan, Guoxun Zhang, Xiaoxu Li, Zheng Jiang, Xing Lin, Lu Fang, Bing Zhou, Peng Xi, Jingtao Fan*, Li Yu*, and Qionghai Dai*. Iterative tomography with digital adaptive optics permits hour-long intravital observation of 3D subcellular dynamics at millisecond scale. Cell. 2021 June 10; 184,3318-3332 e3317.

8. Mingli Zhu#, Qin Zou#, Rongyao Huang, Ying Li, Xudong Xing, Jianhuo Fang, Liang Ma, Lifei Li, Xuerui Yang*, and Li Yu*. Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells. Cell Res. 2021 Feb; 31,237-240.

9. DongJiang #, Zheng Jiang #, Di Lu, Xuan Wang, Haisha Liang, Junfeng Zhang, Yaping Meng, Ying Li, Danni Wu, Yuwei Huang, Yuling Chen, Haiteng Deng, Qing Wu, Jingwei Xiong, Anming Meng * and Li Yu *. Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation. Nat Cell Biol. 2019 Aug;21(8):966-977.

10. Yuwei Huang #, Ben Zucker #, Shaojin Zhang #, Sharon Elias, Yun Zhu, Hui Chen, Tianlun Ding, Ying Li, Yujie Sun, Jizhong Lou, Michael M.Kozlov *and Li Yu *. Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains. Nat Cell Biol. 2019 Aug;21(8):991-1002.

11. Danni Wu#, Yue Xu,Ding, Tianlun Ding, Yan Zu, Chun Yang *and Li Yu*.Pairing of integrins with ECM proteins determines migrasome formation . Cell Research.2017; 27:1397-1400.

12. Na Mi#, Yang Chen#, Shuai Wang, Mengran Chen, Mingkun Zhao, Guang Yang,MeishengMa, Qian Su,Sai Luo, Jingwen Shi, Jia Xu, Qiang Guo, Ning Gao, Yujie Sun, Zhucheng Chen* and Li Yu*.CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane. Nature Cell Biology.2015 Sep;17(9):1112-23.

13. Liang Ma#, Ying Li#, Junya Peng#, Danni Wu, Xiaoxin Zhao, Yitong Cui, Lilian Chen, Xiaojun Yan, Yanan Du, Li Yu*. Discovery of the migrasome, an organelle mediates release of cytoplasmic contents during cell migration. Cell Research.2015 Jan;25(1):24-38. (Cover Story)

14. Yueguang Rong#, Mei Liu, Liang Ma, Wanqing Du, Hanshuo Zhang, Yuan Tian, Zhen Cao, Ying Li, He Ren, Chuanmao Zhang, Lin Li, She Chen, Jianzhong Xi*& Li Yu*. Clathrin and phosphatidylinositol 4,5-bisphosphate regulate autophagic lysosome reformation. Nature Cell Biology. 2012 Sep;14(9):924-34.

15. Cong Yi#, Meisheng Ma, Leili Ran, Jingxiang Zheng, Jingjing Tong, Jing Zhu, Chengying Ma, Yufen Sun, Shaojin Zhang, Wenzhi Feng, Liyuan Zhu,Yan Le, Xingqi Gong,Xianghua Yan, Bing Hong, Fen-Jun Jiang, Zhiping Xie, Di Miao, Haiteng Deng, Li Yu *.Function and Molecular Mechanism of Acetylation in Autophagy Regulation. Science. 2012 Apr; 27, 474-477.

●  荣誉、奖励及参加学术团体的情况：

2012年“揭示营养匮乏引发细胞自噬的分子机制”荣获2012年度中国科学十大进展

2013年  荣获2013年度第六届谈家桢生命科学创新奖

2016年  创新人才推进计划中青年科技创新领军人才

2021年 荣获中国细胞生物学会杰出成就奖

 

●  联系方式：

电话：+86-10-62792880(办公室)

E-mail: liyulab@mail.tsinghua.edu.cn  

网页：https://liyu-lab-tsinghua.github.io/