XIAOFENG FANG PH.D.
Associate Professor
2005 - 2009 B.S.A., Northwestern A&F University, Xi’an
2009 - 2015 Ph.D., Peking Union Medical College & National Institute of Biological Sciences (NIBS)
2015 - 2017 Postdoctoral Scientist, Tsinghua University, Beijing
2017 - 2020 Marie Skłodowska-Curie Fellow, Postdoctoral Scientist, John Innes Centre, UK
2020 - present Assistant Professor, Associate Professor, School of Life Sciences, Tsinghua University, Beijing
Research interest
The biomolecular condensates are emerging as a central way for cellular compartmentalization. Most of the biomolecular condensates are assembled via liquid-liquid phase separation (LLPS). Using a combination of genetics, biochemistry, cell biology and bioinformatics, my lab is focusing on the assembly and biological functions of biomolecular condensates during plant development and stress responses.
Selected publications
1. Wang Y#, Li S#, Mokbel M#, May AI, Liang Z, Zeng Y, Wang W, Zhang H, Yu F, Sporbeck K, Jiang L, Aland S, Agudo-Canalejo J, Knorr RL*, Fang X*. (2024) Biomolecular condensates mediate bending and scission of endosome membranes. Nature. 634(8036):1204-1210.
2. Miao Y*, Chodasiewicz M*, Fang X*. (2024) Navigating biomolecular condensates in plants from patterns to functions. Molecular Plant. 17(9):1329-1332.
3. Fang X*, Li P*. (2024) SnapShot: Condensates in plant biology. Cell. 187(11):2894-2894.
4. Wang Y, He S*, Fang X*. (2023) Emerging roles of phase separation in plant transcription and chromatin organization. Current Opinion in Plant Biology. 75:102387
5. Zhang H#, Peng F#, He C#, Liu Y#, Deng H*, Fang X*. (2023) Large-scale identification of potential phase separation proteins from plants using a cell-free system. Molecular Plant. 16(2):310-313.
6. Wang B#, Zhang H#, Huai J#, Peng F, Wu J, Lin R*, Fang X*. (2022) Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis. Nature Chemical Biology. 18(12):1361-1369.
7. Lin Y*, Fang X*. (2021) Phase Separation in RNA Biology. J Genet Genomics. 48(10):872-880 (Invited Review)
8. Fang X*, Wu Z, Raitskin O, Webb K, Voigt P, Lu T, Howard M, Dean C (2020) The 3' processing of antisense RNAs physically links to chromatin-based transcriptional control. PNAS. 117(26):15316-15321.
9. Fang X#, Wang L#, Ishikawa R#, Li Y, Fiedler M, Liu F, Calder G, Rowan B, Weigel D, Li P, Dean C. (2019) Arabidopsis FLL2 promotes liquid-liquid phase separation of polyadenylation complexes. Nature. 569(7755): 265-269.
See full list at https://www.ncbi.nlm.nih.gov/myncbi/xiaofeng.fang.1/bibliography/public/
Contact information
Email: xffang@mail.tsinghua.edu.cn
Lab website: http://fanglab.life.tsinghua.edu.cn/
Address: 4-214, Biotech Building, Tsinghua University
Tel: 010-62781942
