Daoxin XIE Ph.D.
Professor Academician of the Chinese Academy of Sciences
2006-present: Professor, Tsinghua University
2002-2006: Senior Scientist, Principal Investigator, Institute of Molecular and Cell Biology, Singapore
1999-2002: Senior Scientist, Principal Investigator, Institute of Molecular Agrobiology; Adjunct Assistant Professor, National University of Singapore
1994-1999: Senior Research Associate (Postdoc), University of East Anglia, UK
1990-1994: Postdoctoral Researcher, John Innes Centre; Leicester University, UK
1987-1990: Ph.D., Chinese Academy of Agricultural Sciences
1984-1987: MSc., Chinese Academy of Agricultural Sciences
1983-1984: Research Assistant, Hunan Cotton Research Institute
1979-1983: BSc., Hunan Agricultural College
Xie lab is interested in plant hormone biology, with a special focus on perception and signaling mechanisms of jasmonate (JA) and strigolactone (SL). Xie lab has revealed perception mechanisms for JA and SL: COI1 serves as a JA receptor, which binds active JA molecules to form a new platform that recruits JAZ repressors for degradation to trigger JA-regulated plant defense and development; D14 acts as a non-canonical receptor for SL with dual functions of enzyme and receptor, which hydrolyzes SL, undergoes significant conformation change to form a new platform with the lid-closed cavity that recruits signal components (such as the F-box protein D3/MAX2 and repressor protein D53/SMXLs) to trigger SL responses.
Plant Biology, Plant Molecular Biology, Scientific Writing
1. Yan C, Fan M, Yang M, Zhao J, Zhang W, Su Y, Xiao L, Deng H and Xie D. (2018). Injury Activates Ca2+/Calmodulin-Dependent Phosphorylation of JAV1-JAZ8-WRKY51 Complex for Jasmonate Biosynthesis. Molecular Cell, 70(1), 136-149.
2. Yao R, Chen L and Xie D. (2018). Irreversible strigolactone recognition: a non-canonical mechanism for hormone perception. Current Opinion in Plant Biology, 45, 155-161.
3. Yao R, Wang F, Ming Z, Du X, Chen L, Wang Y, Zhang W, Deng H and Xie D. (2017). ShHTL7 is a non-canonical receptor for strigolactones in root parasitic weeds. Cell Research, 27(6), 838.
4. Wu D, Qi T, Li W, Tian H, Gao H, Wang J, Ge J, Yao R, Ren C, Wang X, Liu Y, Kang L, Ding S and Xie D. (2017) Viral effector protein manipulates host jasmonate signaling to attract insect vectors. Cell Research, 27(3), 402.
5. Yao R, Ming Z, Yan L, Li S, Wang F, Ma S, Yu C, Yang M, Chen L, Chen L, Li Y, Yan C, Miao D, Sun Z, Yan J, Sun Y, Wang L, Chu J, Fan S, He W, Deng H, Nan F, Li J, Rao Z, Lou Z and Xie D. (2016) DWARF14 is a non-canonical hormone receptor for strigolactone. Nature, 536(7617), 469. (Featured in Nature and Science Signaling)
6. Qi T, Wang J, Huang H, Liu B, Gao H, Liu Y, Song S and Xie D. (2015) Regulation of Jasmonate-Induced Leaf Senescence by Antagonism between bHLH Subgroup IIIe and IIId Factors in Arabidopsis. Plant Cell, 27(6), 1634-1649.
7. Qi T, Huang H, Song S and Xie D. (2015) Control of Jasmonate-regulated Stamen Development and Seed Production by a bHLH-MYB Complex in Arabidopsis. Plant Cell, 27(6), 1620-1633.
8. Qi T, Huang H, Wu D, Yan J, Qi Y, Song S and Xie D. (2014). Arabidopsis DELLA and JAZ Proteins Bind the WD-repeat/bHLH/MYB Complex to Modulate Gibberellin and Jasmonate Signaling Synergy. Plant Cell, 26(3), 1118-1133.
9. Song S, Huang H, Gao H, Wang J, Wu D, Liu X, Yang S, Zhai Q, Li C, Qi T and Xie D. (2014) Interaction of MYC2 with EIN3 Modulates Antagonism between Jasmonate and Ethylene Signaling. Plant Cell, 26(1), 263-279.
10. Hu P, Zhou W, Cheng Z, Fan M, Wang L and Xie D. (2013) JAV1 controls Jasmonate-regulated plant defense. Molecular Cell, 50(4), 504-515 (cover story; featured in Mol. Cell)
11. Song S, Qi T, Wasternack C. and Xie D. (2014). Jasmonate signaling and crosstalk with gibberellin and ethylene. Current Opinion in Plant Biology, 21, 112-119.
12. Yan J, Li H, Li S, Yao R, Deng H, Xie Q and Xie D. (2013) The Arabidopsis F-box protein CORONATINE INSENSITIVE 1 is stabilized by SCFCOI1 and degraded via the 26S proteasome pathway. Plant Cell, 25(2), 486-498. (recommended by Faculty 1000)
13. Song S, Qi T, Fan M, Zhang X, Gao H, Huang H, Wu D, Guo H and Xie D. (2013) The bHLH Subgroup IIId Factors Negatively Regulate Jasmonate-mediated Plant Defense and Development. PLoS Genetics, 9(7), e1003653.
14. Qi T, Song S, Ren Q, Wu D, Huang H, Chen Y, Fan M, Peng W, Ren C and Xie D. (2011) The Jasmonate-ZIM-domain Proteins Interact with the WD-repeat/bHLH/MYB Complexes to Control Jasmonate-regulated Anthocyanin Accumulation and Trichome Initiation in Arabidopsis. Plant Cell, 23(5), 1795-1814.
15. Shan X, Yan J and Xie D. (2012) Comparison of phytohormone signaling mechanisms. Current Opinion in Plant Biology, 15(1), 84-91.
16. Song S, Qi T, Huang H, Ren Q, Wu D, Chang C, Peng W, Liu Y, Peng J and Xie D. (2011) The Jasmonate-ZIM-domain Proteins Interact with the R2R3-MYB Transcription Factors MYB21 and MYB24 to Control Jasmonate-regulated Stamen Development in Arabidopsis. Plant Cell, 23(3), 1000-1013.
17. Yan J, Zhang C, Gu M, Bai Z, Zhang W, Qi T, Cheng Z, Peng W, Luo H, Nan F, Wang Z and Xie D. (2009) The Arabidopsis CORONATINE INSENSITIVE 1 protein is a jasmonate receptor. Plant Cell, 21(8), 2220-2236 (recommended by Faculty 1000, featured in Nat. Chem. Bio. and Plant Cell)
18. Cheng H, Song S, Xiao L, Soo H, Cheng Z, Xie D and Peng J. (2009) Gibberellin Acts Through Jasmonate to Control the Expression of MYB21, MYB24 and MYB57 to Promote Stamen Filament Growth in Arabidopsis. PLoS Genetics, 5(3), e1000440.
19. Tan L, Li X, Liu F, Sun X, Li C, Zhu Z, Fu Y, Cai H, Wang X, Xie D and Sun C. (2008) Control of a key transition from prostrate to erect growth in rice domestication. Nature Genetics, 40(11), 1360-1364.
20. Xiao S, Dai L, Liu L, Wang Z, Peng W and Xie D. (2004) COS1: an Arabidopsis coi1 suppressor essential forregulation of jasmonate-mediated plant defense and senescence. Plant Cell, 16(5), 1132-1142.
21. Liu F, Ni W, Griffith M E, Huang Z, Chang C, Peng W, Ma H and Xie D. (2004) The ASK1 and ASK2 Genes Are Essential for Arabidopsis Early Development. Plant Cell, 16(1), 5-20.
22. Xu L, Liu F, Lechner E, Genschik P, Crosby W L, Ma H, Peng W, Huang D and Xie D. (2002) The SCF (COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. Plant Cell, 14(8), 1919-1935.
23. Xie D, Feys F, James S, Nieto-Rostro M and Turner J. (1998) COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertility. Science, 280(5366), 1091-1094.
Tel：+86-10-62781575 (office); 62773664 (lab)