Da Mi    Ph.D.

Assistant Professor


2001-2005  Nankai University, China/B.S.
2005-2008  Nankai University, China/M.Sc.
2008-2013  University of Edinburgh, UK/Ph.D.
2013-2015  University of Edinburgh, UK/Postdoctoral Fellow
2015-2020  King’s College London, UK/Postdoctoral Fellow
2020-present  School of Life Sciences, Tsinghua University, China/Assistant Professor
2020-present Center for Life Sciences & IDG/McGovern Institute for Brain Research at Tsinghua University, Tsinghua University, China/Principal Investigator

 

●  Research interest:


The cerebral cortex is the seat of higher-order brain functions. It consists of a multitude of specialized, precisely positioned and interconnected cell types that assemble into specialized neuronal circuits. One major goal of neuroscience is to understand how small pools of neural progenitor cells generate the vast diversity of neuronal cell types during brain development. Our research group seeks to uncover cellular and molecular mechanisms regulating the emergence of neuronal diversity in the developing cerebral cortex. We also study the role of cellular heterogeneity in neurodevelopmental disorders (NDDs), with the ultimate goal of identifying cell types and their maturation stages that are closely associated with NDDs and understanding cell type-specific functions of disease susceptibility genes in cortical development.


●  Selected publications:


1. Mi, D., Li, Z., Lim, L., Li, M., Moissidis, M., Yang, Y., Gao, T., Hu, T.X., Pratt, T., Price, D.J., Sestan, N., and Marín, O. (2018). Early emergence of cortical interneuron diversity in the mouse embryo. Science. 360, 81-85.

2. Mi D., Manuel M., Huang Y-T., Mason JO., and Price DJ (2018) Pax6 Lengthens G1 Phase and Decreases Oscillating Cdk6 Levels in Murine Embryonic Cortical Progenitors. Front. Cell. Neurosci. 12, 419.

3.  Lim, L. *, Mi, D. *, Llorca, A., and Marín, O. (2018). Development and Functional Diversification of Cortical Interneurons. Neuron. 100, 294-313.

4. Manuel M. *, Mi D. *, Mason JO., and Price DJ. (2015). Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor. Frontiers in cellular neuroscience. 9, 70.

5. Mi, D., Carr, C.B., Georgala, P.A., Huang, Y.T., Manuel, M.N., Jeanes, E., Niisato, E., Sansom, S.N., Livesey, F.J., Theil, T., Hasenpusch-Theil, K., Simpson, T., Mason, J., and Price D.J. (2013). Pax6 Exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and Hypophosphorylation of pRb. Neuron. 78, 269–284.


●  Award:


IBRO World Congress Trave Grant (2019)
Guarantors of Brain Travel Award (2019)
University of Edinburgh/ NeuroResearchers Fund Award (2014)
Member of British Neuroscience Association (2013-2019)

●  Contact information:


Tel:010-62793866

E-mail:mida@mail.tsinghua.edu.cn

Address:B202 Biomedical Sciences Building, Tsinghua University, Beijing, China, 100084