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Guoqiang CHEN Ph.D.

Professor

1981-1985 BSc, South China University of Technology, Guangzhou, China

1986-1989 PhD, Graz University of Technology, Graz, Austria

1990-1992 Postdoc., University of Nottingham, UK

1992-1994 Postdoc., University of Alberta, Canada

1994-1997 Associate Professor, Tsinghua University

1997-Present Professor, Tsinghua University

Research interest

Synthetic Biology; Microbial Metabolic Engineering; Biological Materials; Industrial Biotechnology

Selected publications

1. Yiling Chen, Xu Liu, Lizhan Zhang Jishuai Yang, Weike Guo, Shuang Zheng, Jiale Wang, Fuqing Wu, Xu Yan, Qiong Wu, Chen GQ. Cell Sizes Matter for Industrial Bioproduction, A Case of Polyhydroxybutyrate. Advanced Science 2025, 2412256 (DOI: 10.1002/advs.202412256)

2. Zonghao Zhang, Shuang Zheng, Zhongnan Zhang, Fuqing Wu, Qiong Wu, Chen GQ. Lactose Induced Bioproduction by Halomonas Grown under Open Conditions. Chemical Engineering Journal 507 (2025) 160468 https://doi.org/10.1016/j.cej.2025.160468

3. Shuang Zheng, Mingwei Shao, Wanze Wang, Chen GQ. Next-generation biotechnology inspired by extremes. EMBO Reports 27 (2025) 1-5 (DOI:10.1038/s44319-025-00389-6)

4. Yiping Yuan，Huan Wang，Hongtao He，Zhongnan Zhang，Fang Yang， Yiling Chen, Fuqing Wu, Qiong Wu, Chen GQ. Polyhydroxyalkanoate Production by Engineered Halomonas Grown in Lignocellulose Hydrolysate. Bioresource Technology 425 (2025) 132313 (doi.org/10.1016/j.biortech.2025.132313)

5. Hongtao He, Ng Wuh Jer, Qitiao Hu, Zhongnan Zhang, Simian Sun, Geyuan Xu, Shimao Yang, Shuang Zheng, Xu Liu, Qiong Wu*, Chen GQ*. Engineering Halomonas bluephagenesis for Pilot Production of Terpolymers (3-Hydroxybutyrate, 4-Hydroxybutyrate and 3-Hydroxyvalerate) from Glucose. Metabolic Engineering 90 (2025) 117-128 (https://doi.org/10.1016/j.ymben.2025.03.003)

6. Xu Liu, Helen Park, Yannic Sebastian Ackermann, Luc Avérous, Hendrik Ballerstedt, Werner Besenmatter, Blas Blázquez, Uwe T. Bornscheuer, Yannick Branson, William Casey, Víctor de Lorenzo, Weiliang Dong, Tilman Floehr, Manuel S. Godoy, Yu Ji, Andreas Jupke, Jürgen Klankermayer, David San León, Luo Liu, Xianrui Liu, Yizhi Liu, Maria T. Manoli, Esteban Martínez-García, Tanja Narancic, Juan Nogales, Kevin O’Connor, Ole Osterthun, Rémi Perrin, M. Auxiliadora Prieto, Eric Pollet, Alexandru Sarbu, Ulrich Schwaneberg, Haijia Su, Zequn Tang, Till Tiso, Zishuai Wang, Ren Wei, Gina Welsing, Nick Wierckx, Birger Wolter, Gang Xiao, Jianmin Xing, Yilin Zhao, Jie Zhou, Tianwei Tan, Lars M. Blank, Min Jiang, Guo-Qiang Chen. Exploring biotechnology for plastic recycling，degradation, and upcycling for a sustainable future. Biotechnology Advances 81 (2025) 108544 (doi.org/10.1016/j.biotechadv.2025.108544)

7. Yiling Chen, Weike Guo, Rou Wen, Guo-Qiang Chen. An Automatic Lytic System for Downstream Purification of PHA Produced by Halomonas. Chemical Engineering Journal. 517 (2025)164425 (https://doi.org/10.1016/j.cej.2025.164425)

8. Jiangnan Chen, Fang Yang, Xinyu Chen, Yiling Chen, Zhenghao Xu, Shi Mu, Guo-Qiang Chen*. Production and Characterization of Copolymers Consisting of 3-Hydroxybutyrate and Adjustable Lactate by Engineered Halomonas bluephagenesis from Glucose. Bioresource Technology 434 (2025) 132833 (https://doi.org/10.1016/j.biortech.2025.132833)

9. Mingwei Shao, Zhongnan Zhang, Xiaofan Jin, Ding Jun and Chen GQ. An Orthogonal Transcription Mutation System Generating All Transition Mutations for Accelerated Protein Evolution in vivo. Nature Communications (2025) 16: 6041 (DOI:10.1038/s41467-025-61354-4)

10. Jiale Wang, Xu Yan, Shuang Zheng, Rou Wen, Yiling Chen, Weinan Yang, Junting Sheng, Qiong Wu, Fuqing Wu, Guo-Qiang Chen. Biosynthesis of Poly(δ-valerolactone) (PVL) by Halomonas bluephagenesis. Chemical Engineering Journal 519 (2025) 165410 (doi.org/10.1016/j.cej.2025.165410)

11. Mengke Ji, Fang Yang, Zhongnan Zhang, Huan Wang, Te Gao, Yixin Gao, Yaoyao Zhang, Jinghui Wang, Qiong Wu, Fuqing Wu, Guo-Qiang Chen. Production of polyhydroxyalkanoate from acetate by metabolically engineered Halomonas bluephagenesis. Chemical Engineering Jornal 524 (2025) 168915 https://doi.org/10.1016/j.cej.2025.168915

12. Yuying Guan, Fang Yang, Cuihuan Zhao, Lizhan Zhang, Rou Wen, Fuqing Wu, Guo-Qiang Chen. CRISPR/AID-Mediated Multiplex Genome Editing in Halomonas spp.: A Robust Toolbox for Industrial Strain Development. Chemical Engineering Journal https://doi.org/10.1016/j.cej.2025.171411 526 (2025) 171411

13. Rou Wen, Yiling Chen, Jiale Wang, Weinan Yang, Yang Fang, Qiong Wu, Fuqing Wu, Xu Yan, Guo-Qiang Chen. Pilot production of P(3HB-co-4HB) by engineered Halomonas bluephagenesis harboring an endogeneous plasmid grown on glucose. Metabolic Engineering 94 (2025) 153-168 https://doi.org/10.1016/j.ymben.2025.11.017

14. Simian Sun, Shimao Yang, Yu Qiu, Jun Ding, Wanze Wang, Fuqing Wu, Guo-Qiang Chen. Life Cycle Design of Polyhydroxyalkanoates (PHA). National Science Review 12 (12) (2025) nwaf517 (DOI: 10.1093/nsr/nwaf517)

Awards

2023 International Metabolic Engineering Award

2022 Natural Resources Science and Technology Award - Science and Technology Progress Award

2021 Key Technology for Production of High Quality PLA and PHA together with Related Detivated Products

2012 “Basic Research on Application of Polyhydroxyalkanoates as a Tissue Engineering Material” Silver Medal of Scientific Achievement Awarded by Beijing Minicipal Government

2002 National Invention Silver Medal Award (Chinese Ministry of Sci and Technol)

Contact information

Tel：010－62783844 (office)