Qiong Wu Ph.D.
Associate Professor
1991-1996 B.S, Tsinghua University
1996-2001 Ph.D, Tsinghua University
Lecturer, School of Life Sciences, Tsinghua University (2001)
Associate professor, School of Life Sciences, Tsinghua University (2006)
PhD advisor, School of Life Sciences, Tsinghua University (2010)
Research interest
Synthetic Biology & Regenerative Medicine: Advancing RNA-based technologies for cellular state sensing and fate regulation, with applications in gene/cell therapy and in situ tissue regeneration/repair.
Engineering synthetic gene circuits to investigate mammalian cell state dynamics and regulatory mechanisms in tumor progression and wound healing.
Developing in situ regenerative strategies for lung fibrosis, rheumatoid arthritis, and intestinal inflammation, with a focus on repair mechanisms and cell engineering.
Designing rational RNA modules for controlled gene replication and expression, enabling precision vaccine development.
Constructing cross-domain (prokaryotic/eukaryotic) synthetic biological systems for biomanufacturing, biotherapeutics, and artificial biosystems.
Courses offered
Genetic Experiments for undergraduate students
Selected publications
1. Wang L, Hao M, Xu Y, Wang Z, Xie H, Zhang B, Zhang X, Lin J, Sun X, Wang J, Wu Q. Adipose-derived stem cells attenuate rheumatoid arthritis by restoring CX3CR1+ synovial lining macrophage barrier. 2025. Stem Cell Res Ther 16:111.
2. Zhang M, Zhang X, Xu YY, Xiang YH, Zhang B, Xie Z, Wu Q, Lou CB. High-resolution and programmable RNA-IN and RNA-OUT genetic circuit in living mammalian cells. 2024. Nat Commun 15:8768.
3. Chen TY, Zhang B, Xie HQ, Huang CY, Wu Q. GRHL2 regulates keratinocyte EMT-MET dynamics and scar formation during cutaneous wound healing. 2024. Cell Death Dis 15:748.
4. Ren K, Zhao YQ, Chen GQ, Ao X, Wu Q. Construction of a Stable Expression System Based on the Endogenous hbpB/ hbpC Toxin-Antitoxin System of Halomonas bluephagenesis. 2024. ACS Synth Biol 13:61-67.
5. Chen TY, Jia WY, Zhang B, Xie HQ, Wu Q. EMT transcription factors activated circuits: A novel tool to study EMT dynamics and its therapeutic implications. 2023. Synth Syst Biotechnol 9:1-10.
6. Rahman M, Wang ZY, Li JX, Xu HW, Wang R, Wu Q. Single-Cell RNA Sequencing Reveals the Interaction of Injected ADSCs with Lung-Originated Cells in Mouse Pulmonary Fibrosis. 2022. Stem Cells Int 2022:9483166.
7. Li JX, Luo HF, Wang R, Lang JD, Zhu SY, Zhang ZM, Fang JH, Qu KK, Lin YT, Long HZ, Yao Y, Tian G, Wu Q. 2016. Systematic Reconstruction of Molecular Cascades Regulating GP Development Using Single-Cell RNA-Seq. Cell Reports 15: 1467-80
8. Yao Y, Jin SH, Long HZ, Yu YT, Zhang ZM, Cheng G, Xu CW, Ding Y, Guan Q, Li N, Fu SN, Chen XJ, Yan YB, Zhang HS, Tong P, Tan Y, Yu Y, Fu SS, Li J, He GJ, Wu Q. 2015. RNAe: an effective method for targeted protein translation enhancement by artificial non-coding RNA with SINEB2 repeat. Nucleic Acids Research 43
9. Yao Y, He Y, Guan Q, Wu Q. 2014. A tetracycline expression system in combination with Sox9 for cartilage tissue engineering. Biomaterials 35: 1898-906
10. Wang Y, Jiang XL, Yang SC, Lin X, He Y, Yan C, Wu L, Chen GQ, Wang ZY, Wu Q. 2011. MicroRNAs in the regulation of interfacial behaviors of MSCs cultured on microgrooved surface pattern. Biomaterials 32: 9207-17
Awards
2001 1st Class Award for Outstanding Scientific Achievement (by Beijing Government) (The Third Contributor)
2002 National Invention Silver Medal Award (Chinese Ministry of Sci and Technol) (The third Contributor)
2004 1st Class Award for Beijing Municipal education achievement (The Third Contributor)
2005 2nd Class Award for National Teaching achievement (The Third Contributor)
2008 2nd Class Award for Tsinghua University Teaching achievement (The Fourth Contributor)
2008 New Century Excellent Talent Scheme supported by Ministry of Education
2012 2nd Class Award for Beijing Municipal Science and Technology Progress (The Second Contributor)
Contact information
Tel：010-62771664
Fax：010-62794217
Email：wuqiong@tsinghua.edu.cn
