Jiawei WANG Ph.D.
Associate Professor
2001 University of Science and Technology of China／B.S.
2005 Institute of Physics, Chinese Academy of Sciences ／Ph .D.
2005－2008 Argonne National Laboratory, USA／Postdoctoral Fellow
2008－2011 School of Life Sciences, Tsinghua University／Senior Engineer
2011－2017 School of Life Sciences, Tsinghua University／Assistant Professor
2017-present School of Life Sciences, Tsinghua University, China／Associate Professor
Research interest
Mannose transport complex (man-PTS) is an important member of bacterial phosphotransferase system (PTS), which is responsible for the uptake of glucose, mannose and various sugars. In addition, man-PTS has been reported as a target of related bacteriocins, which participate in or mediate the bactericidal effect. Our team has analyzed the structure of man-PTS from Escherichia coli, the target of bacteriocin. In the future, we will continue to study the bactericidal mechanism of bacteriocins and man-PTS by means of crystallography and cryo- electron microscopy, and provide ideas for the design and development of new antibacterial drugs and food additives. At the same time, we explore the difficult problems in the process of structural analysis and develop new structural analysis methods.
Selected publications
1. Gu Z, Ge X*, Wang J*. Structure of an F-type phage tail-like bacteriocin from Listeria monocytogenes. Nature Communications, 2025; 16(1):1695.
2. Ge X, Wang J*. Structural mechanism of bacteriophage lambda tail’s interaction with the bacterial receptor. Nature Communications, 2024; 15(1):4185.
3. Gu Z, Wu K, Wang J*. Structural morphing in the viral portal vertex of bacteriophage lambda. Journal of Virology, 2024; 98(5):e0006824.
4. Wang C, Duan J, Gu Z, Ge X, Zeng J*, Wang J*. Architecture of the bacteriophage lambda tail. Structure, 2024; 32(1):35-46.e3.
5. Li R, Duan J, Zhou Y, Wang J*. Structural basis of the mechanisms of action and immunity of lactococcin A, a class IId bacteriocin. Appl Environ Microbiol. 2023; 89:e00066-23.
6. Zhu L, Zeng J, Wang J*. Structural basis of the immunity mechanisms of pediocin-like bacteriocins. Appl Environ Microbiol. 2022; 88(13):e0048122.
7. Wang C, Zeng J*, Wang J*. Structure basis of bacteriophage lambda capsid maturation. Structure, 2022; S0969-2126(21)00461-5.
8. Zhu L, Zeng J, Wang C, Wang J*. Structural basis of pore formation in the mannose phosphotransferase system by pediocin PA-1. Appl Environ Microbiol. 2022; 88(3):e0199221.
9. Huang K, Zeng J, Liu X, Jiang T*, Wang J*. Structure of the mannose phosphotransferase system (man-PTS) complexed with microcin E492, a pore-forming bacteriocin. Cell Discovery, 2021; 7(1):20.
10. Li L, Dai S, Gao GF*, Wang J*. Lattice-translocation defects in specific crystals of the catalytic head domain of influenza neuraminidase. Acta Crystallogr D Struct Biol. 2020; 76:1057-1064 (Cover).
11. Liu X, Zeng J, Huang K, Wang J*. Structure of the mannose transporter of the bacterial phosphotransferase system. Cell Research, 2019; 29(8):680-682.
12. Luo P, Dai S, Zeng J, Duan J, Shi H, Wang J*. Inward-facing conformation of L-ascorbate transporter suggests an elevator mechanism. Cell Discovery, 2018; 4:35.
13. Zhou N, Wang H*, Wang J*. EMBuilder: A Template Matching-based Automatic Model-building Program for High-resolution Cryo-Electron Microscopy Maps. Sci Rep. 2017; 7(1):2664.
14. Wang J, Wang W, Song W, Han Z, Zhang H, Chai J*, Wang H*, Wang J*. An improved method for phasing crystal structures with low non-crystallographic symmetry using cryo-electron microscopy data. Protein & Cell, 2015; 6(12):919-23.
15. Luo P, Yu X, Wang W, Fan S, Li X*, Wang J*. Crystal structure of a phosphorylation-coupled vitamin C transporter. Nat Struct Mol Biol. 2015; 22(3):238-41 (Cover).
Contact information
Tel: +86-10-62782124
Fax: +86-10-62782124
E-mail: jwwang@tsinghua.edu.cn
Address: A317, Biomedicine Hall, Tsinghua University
