Maojun YANG Ph.D.
Professor
1995－1999 B.S., Jilin University, Changchun, P.R.China
1999－2003 Ph.D., Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, P.R.China
2003－2004 Senior Visiting Scholar, University of Lübeck, Lübeck, Germany
2004－2008 Post-doctoral Fellow, University of Texas, Southwestern Medical Center, Dallas, TX
2008-2013 Special researcher
2013-present Professor, School of Life Sciences, Tsinghua University
Research interest
We mainly work on structural biology combined with cell and molecular biology, together with biochemistry as the research means to engage in the research on the structure and function of cell induced external signals and proteins related to cell energy metabolism, and carry out drug design and clinical application research based on the high-resolution structure of these biological macromolecules.
Selected publications
1. Gu et.al. The coupling mechanism of mammalian mitochondrial complex I. Nat Struct Mol Biol. 2022 Feb;29(2):172-182.
2. Wang et.al. Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation. Science. 2021 Oct 14:eabl4546.
3. Gu et.al. Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1. Science. 2019 Jun 14;364 (6445):1068-1075.
4. Dong et.al. Structural basis of ubiquitin modification by the Legionella effector SdeA. Nature. 2018 May;557(7707):674-678.
5. Guo et.al. Architecture of human mitochondrial respiratory megacomplex I2III2IV2. Cell. 2017 Sep 7;170(6):1247-1257.e12..
6. Wu et.al. Structure of mammalian respiratory supercomplex I1III2IV1. Cell. 2016, Dec 01; 167(6):1598-1609.e10.
7. Gu et.al. The architecture of the mammalian respirasome. Nature. 2016 Sep 21;537(7622):639-43.
8. Wang et.al. TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel. Cell. 2016 Jun 2;165(6):1454-66.
9. Ge et.al. Architecture of the Mammalian Mechanosensitive Piezo1 Channel. Nature. 2015. Nov 5;527(7576):64-9.
10. Li et.al. Structure of the eukaryotic MCM complex at 3.8 Å. Nature. 2015 Aug 13;524(7564):186-91.
11. Guo et.al. Structural basis for hijacking CBFβ and CUL5 E3 ligase complex by HIV-1 Vif. Nature, 2014 Jan 9;505(7482):229-33.
12. Feng Y et.al. Structural insight into the type-II mitochondrial NADH dehydrogenases. Nature. 2012 Nov 15;491(7424):478-82.
13. She et.al. Structural insight into brassinosteroid perception by BRI1. Nature. 2011 Jun 12;474(7352):472-6.
Contact information
E-mail: maojunyang@mail.tsinghua.edu.cn
