Yiguo WANG Ph.D.
Associate Professor
1997-2001 B.S., School of Life Sciences, Qufu Normal University
2001-2007 Ph.D., Institute of Biochemistry and Cell Biology, SIBS, CAS
2007-2012 Research Associate, Salk Institute for Biological Studies
2012-present Associate Professor, School of Life Sciences, Tsinghua University
Research interest
Metabolic diseases driven by energy surplus, including obesity, diabetes, cardiovascular diseases, and cancer, have reached epidemic proportions worldwide. Hormones play a pivotal role in regulating energy homeostasis, highlighting the importance of discovering novel hormones that counteract energy excess to overcome the current therapeutic limitations of metabolic disorders. Our laboratory has identified several new hormones, and our research focuses on those that suppress energy intake, reduce energy storage, and enhance energy expenditure. We aim to systematically elucidate their molecular mechanisms, refine their functional properties, and explore their potential for clinical translation in metabolic disease treatment.
Selected publications
1. Aijun Long, Yazhuo Wang, Yihua Guo, Jie Hong, Guang Ning, Zhuoxian Meng*, Jiqiu Wang*, Yiguo Wang*. (2025) A famsin-glucagon axis mediates glucose homeostasis. Cell Metab. 37, 629-639.
2. Xiaoliu Shi#, Xiao Hu#, Xinlei Fang#, Liangjie Jia, Fangchao Wei, Ying Peng, Menghao Liu, Aibo Gao, Ke Zhao, Fengyi Chen, Xiaoli Hu, Jie Hong, Guang Ning, Yongfeng Song*, Jiqiu Wang*, Yiguo Wang*. (2025) A feeding-induced myokine modulates glucose homeostasis. Nature Metab. 7, 68-83. (Cover article)
3. Ying Peng#, Liangjie Jia#, Xiao Hu, Xiaoliu Shi, Xinlei Fang, Yifu Qiu, Zhenji Gan, Yiguo Wang*. (2025) Cellular Feimin enhances exercise performance by suppressing muscle thermogenesis. Nature Metab. 7, 84-101. (Cover article)
4. Xiaoli Hu#, Fengyi Chen#, Liangjie Jia, Aijun Long, Ying Peng, Xu Li, Junfeng Huang, Xueyun Wei, Xinlei Fang, Zihua Gao, Mengxian Zhang, Xiao Liu, Ye-Guang Chen, Yan Wang, Huijie Zhang*, Yiguo Wang*. (2024) A gut-derived hormone regulates cholesterol metabolism. Cell 187, 1685-1700. (Cell Best of 2024)
5. Aijun Long#, Yang Liu#, Xinlei Fang, Liangjie Jia, Zhiyuan Li, Jiang Hu, Shuang Wu, Chao Chen, Ping Huang*, Yiguo Wang*. (2023) Famsin, a novel gut-secreted hormone, contributes to metabolic adaptations to fasting via binding to its receptor OLFR796. Cell Res. 33, 273-287. (Cover article)
6. Erwei Li#, Haili Shan#, Liqun Chen#, Aijun Long#, Yuanyuan Zhang#, Yang Liu, Liangjie Jia, Fangchao Wei, Jinbo Han, Tong Li, Xiaohui Liu, Haiteng Deng, Yiguo Wang*. (2019) OLFR734 mediates glucose metabolism as a receptor of Asprosin. Cell Metab. 30, 319-328.
7. Liqun Chen#, Ke Wang#, Aijun Long, Liangjie Jia, Yuanyuan Zhang, Haiteng Deng, Yu Li, Jinbo Han, Yiguo Wang*. (2017) Fasting-induced hormonal regulation of lysosomal function. Cell Res. 27, 748-763.
8. Jinbo Han#, Erwei Li#, Liqun Chen, Yuanyuan Zhang, Fangchao Wei, Jieyuan Liu, Haiteng Deng, Yiguo Wang*. (2015) The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. Nature 524, 243-246.
9. Yiguo Wang, Gang Li, Jason Goode, Jose C. Paz, Kunfu Ouyang, Robert Screaton, Wolfgang H. Fischer, Ju Chen, Ira Tabas, Marc Montminy*. (2012) InsP3 receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature 485, 128-132.
10. Yiguo Wang, Liliana Vera, Wolfgang H Fischer, Marc Montminy*. (2009) The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 460, 534-537.
Contact information
TEL：+86-10-62783209
E-mail:yiguo@mail.tsinghua.edu.cn
