Yeguang CHEN  Ph.D.

Professor   Academician of the Chinese Academy of Sciences

1979-1983  Jiangxi University, BSc of Biology

1983-1986  Jiangxi University, MSc of Zoology

1988-1990  Fordham University, MSc of Cell Biology

1991-1996  Albert Einstein College of Medicine, PhD of Cell Biology

1996-2000  Post-doctoral Research Associate, Memorial Sloan-Kettering Cancer Center/Howard Hughes Medical Institute

2000-2002  Assistant Professor, University of California, Riverside

2002-present  Professor, School of Life Sciences, Tsinghua University



Research interest

He primarily focuses on using multidisciplinary approaches such as molecular biology, cell biology, bioinformatics, as well as organoid technology and animal models, to investigate the self-renewal and differentiation mechanisms of adult stem cells, and explore the molecular mechanisms underlying signal regulation of cell fate and the development of cancer diseases.


Selected publications

1)Wang YL, Lou RY, Zhang Z, Xiao CY, Yu SC, Wei ST, Liu Y, Fu W, Li BJ,  Chen YG#. (2023) Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17, Science Advances. In press.

2)Liu LS, Wang YL, Yu SC, Liu HD, Li YH, Hua S, Chen YG#. (2023) TGF-β promotes inflammation and tumorigenesis in Smad4-deficient intestinal epithelium in a YAP-dependent manner, Advanced Science, e2300708.

3)Kang KX, Shi QN, Wang X, Chen YG#. (2022) Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly, Journal of Cell Biology, 221(12):e202205069.

4)Zhao LZ, Song WL, Chen YG#. (2022) Mesenchymal-epithelial interaction regulates gastrointestinal tract development in mouse embryos. Cell Reports, 40(2):111053.

5)Wang T, Zhang N, Fan SP, Zhao LZ, Song WL, Gong YH, Shen Q, Zhang C, Ren P, Lin CT, Fu W, Gao G, Ma SH#, Bi YH#, Chen YG#.  (2021)  Establishment of human distal lung organoids for SARS-CoV-2 infection. Cell Discovery, 7(1):108.

6)Nong JX, Kang KX, Shi QN, Zhu XC, Tao QH, Chen YG#. (2021)  Phase separation of Axin organizes the β-catenin destruction complex.  Journal of Cell Biology, 220(4): e202012112.

7)Wang YL, Song WL, Wang JL, Wang T, Xiong XC, Qi Z, Fu W#, Yang XR#, Chen YG#. (2020) Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine. Journal of Experimental Medicine, 217(2). pii: e20191130.

8)Liao HW, Li X, Zhao LZ, Wang YL, Wang XD, Wu Y, Zhou X, Fu W, Liu L, Hu HG#, Chen YG#. (2020) A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer. Cell Discovery, 6(35):1.

9)Li YZ, Liu Y, Y. Jeffrey Chiang, Huang F, Li YH, Li XT,Ning YH, Zhang WH, Deng HT, Chen YG#.  (2019)  DNA Damage Activates TGF-β Signaling via ATM-c-Cbl-Mediated Stabilization of the Type II Receptor TβRII. Cell Reports, 28(3):735.

10)Huang F, Shi QN, Li Y, Xu L, Xu C, Chen F, Wang H, Liao H, Chang Z, Liu F, Zhang XH, Feng XH, Han JJ, Luo S, Chen YG#. (2018) HER2/EGFR-AKT signaling switches TGF-β from inhibiting cell proliferation to promoting cell migration in breast cancer. Cancer Research, 78(21):6073.

11)Qi Z, Li YH, Zhao B, Xu C, Liu Y, Li H, Zhang B, Wang X, Yang X, Xie W, Li B, Han J, Chen YG#. (2017) BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes. Nature Communications, 8:13824.

12)Zhao B, Qi Z, Li Y, Wang C, Fu W, Chen YG#. (2015) Non-muscle-myosin-II mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells via the Rac1-PAK1-Akt axis. Nature Communications, 6:7166.

13)Zuo W, Huang F, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng XH, Luo S, Gao C, Chen YG#.  (2013)  c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor.  Molecular Cell, 49(3):499.

14)Li ZW, Fei T, Zhang JP, Zhu GY, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG#.  (2012)  BMP4 Signaling Acts via Dual Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells. Cell Stem Cell, 10:171.

15)Gao C, Cao WP, Bao L, Zuo W, Xie GM, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG#. (2010) Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nature Cell Biology,12(8):781.


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