Qiaoran XI Ph.D.
Associate Professor
1989-1993 Nanjing University, Nanjing B.S.
1998-2004 New York University Medical Center Ph.D.
2004-2005 New York University Medical Center Postdoc
2006-2013 Memorial Sloan-Kettering Cancer Center Postdoc
2013-present School of Life Sciences, Tsinghua University Assistant Professor, Associate Professor
Research interest
The long-term goal of my research is to understand how the cellular signaling and the epigenome interplay to influence development and disease. We have made significant advances in understanding cell context-dependent nature of TGF-β responses. Going forward, we will deepen our investigation of these new players of TGF-β signaling and strive to gain mechanistic insights into their regulatory roles in early development. Built on our exciting findings in our research in BMP signaling and diffuse intrinsic pontine glioma (DIPG), we will continue our collaborative efforts with Tiantan Hospital to uncover how BMP signaling cross-talks with epigenome and exerts different effects in two distinct groups of DIPGs..
Selected publications
1. Wang D, Yan K, Yu H, Li H, Zhou W, Hong Y, Guo S, Wang Y, Xu Chen, Pan C, Tang Y, Liu N, Wu W, Zhang L*, Xi Q*. (2024) Fimepinostat impairs NFκB and PI3K/AKT signaling and enhances gemcitabine efficacy in H3K27M-mutated diffuse intrinsic pontine glioma. Cancer Research. 84(4), p. 598-615.
2. Zhou W#, Yan K# & Xi Q*. (2023) BMP signaling in cancer stemness and differentiation. Cell Regeneration. 12:37. https://doi.org/10.1186/s13619-023-00181-8 (Review)
3. Sun H#, Chen Y#, Yan K, Shao Y, Zhang Q, Lin Y*, Xi Q*. (2023) Recruitment of TRIM33 to cell‐context specific PML nuclear bodies regulates nodal signaling in mESCs. The EMBO Journal. 42(3): e112058.
4. Kong X, Yan K, Deng P, Fu H, Sun H, Huang W, Jiang S, Dai J, Zhang Q, Liu J and Xi Q*. (2022) LncRNA-Smad7 mediates cross-talk between Nodal/TGF-β and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells. Nucleic Acids Research. 5(18): 10526-10543.
5. Sun Y#, Yan K#, Wang Y#, Xu C#, Wang D, Zhou W, Guo S, Han Y, Tang L, Shao Y, Shan S, Zhang Q, Tang Y, Zhang L*, Xi Q*. (2022) Context-dependent tumor suppressive BMP signaling in Diffuse Intrinsic Pontine Glioma regulates stemness through epigenetic regulation of CXXC5. Nature Cancer. 3(9): 1105-1123. (featured article with an editor’s digest)
6. Liang T#, Bai J#, Zhou W, Lin H, Ma S, Zhu X, Tao Q, Xi Q*. (2022) HMCES modulates the transcriptional regulation of nodal/activin and BMP signaling in mESCs. Cell Reports. 40(2):111038.
7. Fu H, Wang T, Kong X, Yan K, Yang Y, Cao J, Yuan Y, Wang N, Kee K, Lu Z, Xi Q*. (2022) A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells. Nature Communications. 13(1): 3984.
8. Zuo F#, Jiang J#, Fu H#, Yan K, Liefke R, Zhang J, Hong Y, Chang Z, Liu N, Wang Z*, Xi Q*. (2022) A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells. Cell Stem Cell. 29(6), 948-961.
9. Luo M, Bai J#, Liu B#, Yan P#, Zuo F, Sun H, Sun Y, Xu X, Song Z, Yang Y, Massagué J, Lan X, Lu Z, Chen YG, Deng H, Xie W, and Xi Q*. (2019) H3K18ac primes mesendodermal differentiation upon nodal signaling. Stem Cell Reports.13(4): 642-656.
10. Sun Y#, Sun Y#, Yan K, Li Z, Xu C, Geng Y, Pan C, Chen X, Zhang l*, Xi Q*. (2019) Potent anti-tumor efficacy of palbociclib in H3.3K27M-mutant diffuse intrinsic pontine glioma. EBioMedicine. 43:171-179. ( featured article with a preview commentary)
11. Tian W#, Yan P#, Xu N, Chakravorty A, Liefke R*, Xi Q* and Wang Z*. (2019) The HRP3 PWWP domain recognizes the minor groove of double-stranded DNA and recruits HRP3 to chromatin. Nucleic Acids Research. 47(10): 5436-5448.
12. Bai J, Xi Q*. (2018) Crosstalk between TGF-β signaling and epigenome. Acta Biochimica Biophys Sin. 50(1): 60-67. (Review)
13. Xia X, Zuo F, Luo M, Sun Y, Bai J, Xi Q*. (2017) Role of TRIM33 in Wnt signaling during mesendoderm differentiation. Sci China Life Sci. 60(10): 1142-1149.
14. Massagué J, and Xi Q. (2012) TGF-β control of stem cell differentiation genes. FEBS Letters. 586: 1953-8. (Review)
15. Xi Q, Wang Z, Zaromytidou AI, Zhang XH, Chow-Tsang L, Liu JX, Kim H, Manova-Todorova K, Kaartinen V, Studer L, Mark W, Patel DJ, and Massagué J*. (2011) A poised chromatin platform for TGFβ access to master regulators. Cell. 147: 1511-24.
Contact information
Tel：+86-10-62789636(lab)
E-mail: xiqiaoran@tsinghua.edu.cn
公众号：
Address：清华大学郑裕彤医学楼
