科研成果
生命学院代表性论文
Ligand efficacy modulates conformational dynamics of the µ-opioid receptor
Zhao, Jiawei; Elgeti, Matthias; O’Brien, Evan S.; Sár, Cecília P.; EI Daibani, Amal; Heng, Jie; Sun, Xiaoou; White, Elizabeth; Che, Tao; Hubbell, Wayne L.; Kobilka, Brian K.; Chen, Chunlai
Nature
Biomolecular condensates mediate bending and scission of endosome membranes
Wang, Yanning; Li, Shulin; Mokbel, Marcel; May, Alexander I.; Liang, Zizhen; Zeng, Yonglun; Wang, Weiqi; Zhang, Honghong; Yu, Feifei; Sporbeck, Katharina; Jiang, Liwen; Aland, Sebastian; Agudo-Canalejo, Jaime; Knorr, Roland L.; Fang, Xiaofeng
Nature
Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity
Zhang, Shouyue; Sun, Ao; Qian, Jing-Mei; Lin, Shuo; Xing, Wenjing; Yang, Yun; Zhu, Han-Zhou; Zhou, Xin-Yi; Guo, Yan-Shuo; Liu, Yun; Meng, Yu; Jin, Shu-Lin; Song, Wenhao; Li, Cheng-Ping; Li, Zhaofu; Jin, Shuai; Wang, Jian-Hua; Dong, Meng-Qiu; Gao, Caixia; Chen, Chunlai; Bai, Yang; Liu, Jun-Jie Gogo
Nature
Molecular basis of human noradrenaline transporter reuptake and inhibition
Tan, Jiaxin; Xiao, Yuan; Kong, Fang; Zhang, Xiaochun; Xu, Hanwen; Zhu, Angqi; Liu, Yiming; Lei, Jianlin; Tian, Boxue; Yuan, Yafei; Yan, Chuangye
Nature
A gut-derived hormone regulates cholesterol metabolism
Hu, Xiaoli; Chen, Fengyi; Jia, Liangjie; Long, Aijun; Peng, Ying; Li, Xu; Huang, Junfeng; Wei, Xueyun; Fang, Xinlei; Gao, Zihua; Zhang, Mengxian; Liu, Xiao; Chen, Ye-Guang; Wang, Yan; Zhang, Huijie; Wang, Yiguo
Cell
Structure-guided discovery of protein and glycan components in native mastigonemes
Huang, Junhao; Tao, Hui; Chen, Jikun; Shen, Yang; Lei, Jianlin; Pan, Junmin; Yan, Chuangye; Yan, Nieng
Cell
A plant mechanism of hijacking pathogen virulence factors to trigger innate immunity
Xiao, Yu; Sun, Guangzheng; Yu, Qiangsheng; Gao, Teng; Zhu, Qinsheng; Wang, Rui; Huang, Shijia; Han, Zhifu; Cervone, Felice; Yin, Heng; Qi, Tiancong; Wang, Yuanchao; Chai, Jijie
Science
Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage
Liu, Zi-Xian; Zhang, Shouyue; Zhu, Han-Zhou; Chen, Zhi-Hang; Yang, Yun; Li, Long-Qi; Lei, Yuan; Liu, Yun; Li, Dan-Yuan; Sun, Ao; Li, Cheng-Ping; Tan, Shun-Qing; Wang, Gao-Li; Shen, Jie-Yi; Jin, Shuai; Gao, Caixia; Liu, Jun-Jie Gogo
Science
Molecular mechanism of substrate recognition and cleavage by human γ-secretase
Guo, Xuefei; Li, Haotian; Yan, Chuangye; Lei, Jianlin; Zhou, Rui; Shi, Yigong
Science
Electrospray-assisted cryo-EM sample preparation to mitigate interfacial effects
Yang, Zi; Fan, Jingjin; Wang, Jia; Fan, Xiao; Ouyang, Zheng; Wang, Hong-Wei; Zhou, Xiaoyu
Nature Methods
Stepwise de novo establishment of inactive X chromosome architecture in early development
Du, Zhenhai; Hu, Liangjun; Zou, Zhuoning; Liu, Meishuo; Li, Zihan; Lu, Xukun; Harris, Clair; Xiang, Yunlong; Chen, Fengling; Yu, Guang; Xu, Kai; Kong, Feng; Xu, Qianhua; Huang, Bo; Liu, Ling; Fan, Qiang; Wang, Haifeng; Kalantry, Sundeep; Xie, Wei
Nature Genetics
LINE-1 transcription activates long-range gene expression
Li, Xiufeng; Bie, Luyao; Wang, Yang; Hong, Yaqiang; Zhou, Ziqiang; Fan, Yiming; Yan, Xiaohan; Tao, Yibing; Huang, Chunyi; Zhang, Yongyan; Sun, Xueyan; Li, John Xiao He; Zhang, Jing; Chang, Zai; Xi, Qiaoran; Meng, Anming; Shen, Xiaohua; Xie, Wei; Liu, Nian
Nature Genetics
Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human
Huang, Wenze; Xiong, Tuanlin; Zhao, Yuting; Heng, Jian; Han, Ge; Wang, Pengfei; Zhao, Zhihua; Shi, Ming; Li, Juan; Wang, Jiazhen; Wu, Yixia; Liu, Feng; Xi, Jianzhong Jeff; Wang, Yangming; Zhang, Qiangfeng Cliff
Nature Genetics
Localized, highly efficient secretion of signaling proteins by migrasomes
Jiao, Haifeng; Li, Xiaopeng; Li, Ying; Guo, Yuting; Hu, Xiaoyu; Sho, Takami; Luo, Yiqun; Wang, Jinyu; Cao, Huizhen; Du, Wanqing; Li, Dong; Yu, Li
Cell Research
Structural insights into human exon-defined spliceosome prior to activation
Zhang, Wenyu; Zhang, Xiaofeng; Zhan, Xiechao; Bai, Rui; Lei, Jianlin; Yan, Chuangye; Shi, Yigong
Cell Research
An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms
Sun, Wenbo; Yang, Tingyu; Sun, Fengming; Liu, Panhong; Gao, Ji; Lan, Xianmei; Xu, Wei; Pang, Yuhong; Li, Tong; Li, Cuifeng; Liang, Qingtai; Chen, Haoze; Liu, Xiaohang; Tan, Wenting; Zhu, Huanhuan; Wang, Fang; Cheng, Fanjun; Zhai, Weiwei; Kim, Han-Na; Zhang, Jingren; Zhang, Linqi; Lu, Lu; Xi, Qiaoran; Deng, Guohong; Huang, Yanyi; Jin, Xin; Chen, Xiangjun; Liu, Wanli
Nature Immunology
Programmable in vitro and in vivo folding of single-stranded nucleic-acid wireframe origami
Zhang, Tianqing; Qian, Xinmin; Cui, Huangchen; Li, Qingting; Du, Xinyu; Fu, Xiaoyu; Gu, Hongzhou; Zeng, Wenwen; Wei, Bryan
Chem
A dual role of ERGIC-localized Rabs in TMED10-mediated unconventional protein secretion
Sun, Yuxin; Tao, Xuan; Han, Yaping; Lin, Xubo; Tian, Rui; Wang, Haodong; Chang, Pei; Sun, Qiming; Ge, Liang; Zhang, Min
Nature Cell Biology
Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators
Liu, Bofeng; He, Yuanlin; Wu, Xiaotong; Lin, Zili; Ma, Jing; Qiu, Yuexin; Xiang, Yunlong; Kong, Feng; Lai, Fangnong; Pal, Mrinmoy; Wang, Peizhe; Ming, Jia; Zhang, Bingjie; Wang, Qiujun; Wu, Jingyi; Xia, Weikun; Shen, Weimin; Na, Jie; Torres-Padilla, Maria-Elena; Li, Jing; Xie, Wei
Nature Cell Biology
Neutrophil-derived migrasomes are an essential part of the coagulation system
Jiang, Dong; Jiao, Lin; Li, Qing; Xie, Renxiang; Jia, Haohao; Wang, Shihui; Chen, Yining; Liu, Siyuan; Huang, Dandan; Zheng, Jiajia; Song, Wenhao; Li, Ying; Chen, Jianfeng; Li, Jinsong; Ying, Binwu; Yu, Li
Nature Cell Biology
Conformational dynamics of CasX (Cas12e) in mediating DNA cleavage revealed by single-molecule FRET
Xing, Wenjing; Li, Danyuan; Wang, Wenjuan; Liu, Jun-Jie Gogo; Chen, Chunlai
Nucleic Acids Research
RASP v2.0: an updated atlas for RNA structure probing data
Mu, Kunting; Fei, Yuhan; Xu, Yiran; Zhang, Qiangfeng Cliff
Nucleic Acids Research
How variable progenitor clones construct a largely invariant neocortex
Shen, Zhongfu; Yang, Jiajun; Zhang, Qiangqiang; Wang, Kuiyu; Lv, Xiaohui; Hu, Xiaolin; Ma, Jian; Shi, Song-Hai
National Science Review
An RdDM-independent function of Pol V transcripts in gene regulation and plant defence
Yuan, Yuxiang; Liu, Yujie; Han, Lu; Li, Yan; Qi, Yijun
Nature Plants
Evolutional heterochromatin condensation delineates chromocenter formation and retrotransposon silencing in plants
Zhang, Weifeng; Cheng, Lingling; Li, Kuan; Xie, Leiming; Ji, Jinyao; Lei, Xue; Jiang, Anjie; Chen, Chunlai; Li, Haitao; Li, Pilong; Sun, Qianwen
Nature Plants
An end-to-end framework for the prediction of protein structure and fitness from single sequence
Chen, Yinghui; Xu, Yunxin; Liu, Di; Xing, Yaoguang; Gong, Haipeng
Nature Communications
In situ structural determination of cyanobacterial phycobilisome-PSII supercomplex by STAgSPA strategy
Zhang, Xing; Xiao, Yanan; You, Xin; Sun, Shan; Sui, Sen-Fang
Nature Communications
Primase promotes the competition between transcription and replication on the same template strand resulting in DNA damage
Zhang, Weifeng; Yang, Zhuo; Wang, Wenjie; Sun, Qianwen
Nature Communications
Structural mechanism of bacteriophage lambda tail's interaction with the bacterial receptor
Ge, Xiaofei; Wang, Jiawei
Nature Communications
High-resolution and programmable RNA-IN and RNA-OUT genetic circuit in living mammalian cells
Zhang, Min; Zhang, Xue; Xu, Yongyue; Xiang, Yanhui; Zhang, Bo; Xie, Zhen; Wu, Qiong; Lou, Chunbo
Nature CommunicationsLigand efficacy modulates conformational dynamics of the µ-opioid receptor
Biomolecular condensates mediate bending and scission of endosome membranes
Wang, Yanning; Li, Shulin; Mokbel, Marcel; May, Alexander I.; Liang, Zizhen; Zeng, Yonglun; Wang, Weiqi; Zhang, Honghong; Yu, Feifei; Sporbeck, Katharina; Jiang, Liwen; Aland, Sebastian; Agudo-Canalejo, Jaime; Knorr, Roland L.; Fang, Xiaofeng
Nature
Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity
Zhang, Shouyue; Sun, Ao; Qian, Jing-Mei; Lin, Shuo; Xing, Wenjing; Yang, Yun; Zhu, Han-Zhou; Zhou, Xin-Yi; Guo, Yan-Shuo; Liu, Yun; Meng, Yu; Jin, Shu-Lin; Song, Wenhao; Li, Cheng-Ping; Li, Zhaofu; Jin, Shuai; Wang, Jian-Hua; Dong, Meng-Qiu; Gao, Caixia; Chen, Chunlai; Bai, Yang; Liu, Jun-Jie Gogo
Nature
Molecular basis of human noradrenaline transporter reuptake and inhibition
Tan, Jiaxin; Xiao, Yuan; Kong, Fang; Zhang, Xiaochun; Xu, Hanwen; Zhu, Angqi; Liu, Yiming; Lei, Jianlin; Tian, Boxue; Yuan, Yafei; Yan, Chuangye
Nature
A gut-derived hormone regulates cholesterol metabolism
Hu, Xiaoli; Chen, Fengyi; Jia, Liangjie; Long, Aijun; Peng, Ying; Li, Xu; Huang, Junfeng; Wei, Xueyun; Fang, Xinlei; Gao, Zihua; Zhang, Mengxian; Liu, Xiao; Chen, Ye-Guang; Wang, Yan; Zhang, Huijie; Wang, Yiguo
Cell
Structure-guided discovery of protein and glycan components in native mastigonemes
Huang, Junhao; Tao, Hui; Chen, Jikun; Shen, Yang; Lei, Jianlin; Pan, Junmin; Yan, Chuangye; Yan, Nieng
Cell
A plant mechanism of hijacking pathogen virulence factors to trigger innate immunity
Xiao, Yu; Sun, Guangzheng; Yu, Qiangsheng; Gao, Teng; Zhu, Qinsheng; Wang, Rui; Huang, Shijia; Han, Zhifu; Cervone, Felice; Yin, Heng; Qi, Tiancong; Wang, Yuanchao; Chai, Jijie
Science
Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage
Liu, Zi-Xian; Zhang, Shouyue; Zhu, Han-Zhou; Chen, Zhi-Hang; Yang, Yun; Li, Long-Qi; Lei, Yuan; Liu, Yun; Li, Dan-Yuan; Sun, Ao; Li, Cheng-Ping; Tan, Shun-Qing; Wang, Gao-Li; Shen, Jie-Yi; Jin, Shuai; Gao, Caixia; Liu, Jun-Jie Gogo
Science
Molecular mechanism of substrate recognition and cleavage by human γ-secretase
Guo, Xuefei; Li, Haotian; Yan, Chuangye; Lei, Jianlin; Zhou, Rui; Shi, Yigong
Science
Electrospray-assisted cryo-EM sample preparation to mitigate interfacial effects
Yang, Zi; Fan, Jingjin; Wang, Jia; Fan, Xiao; Ouyang, Zheng; Wang, Hong-Wei; Zhou, Xiaoyu
Nature Methods
Stepwise de novo establishment of inactive X chromosome architecture in early development
Du, Zhenhai; Hu, Liangjun; Zou, Zhuoning; Liu, Meishuo; Li, Zihan; Lu, Xukun; Harris, Clair; Xiang, Yunlong; Chen, Fengling; Yu, Guang; Xu, Kai; Kong, Feng; Xu, Qianhua; Huang, Bo; Liu, Ling; Fan, Qiang; Wang, Haifeng; Kalantry, Sundeep; Xie, Wei
Nature Genetics
LINE-1 transcription activates long-range gene expression
Li, Xiufeng; Bie, Luyao; Wang, Yang; Hong, Yaqiang; Zhou, Ziqiang; Fan, Yiming; Yan, Xiaohan; Tao, Yibing; Huang, Chunyi; Zhang, Yongyan; Sun, Xueyan; Li, John Xiao He; Zhang, Jing; Chang, Zai; Xi, Qiaoran; Meng, Anming; Shen, Xiaohua; Xie, Wei; Liu, Nian
Nature Genetics
Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human
Huang, Wenze; Xiong, Tuanlin; Zhao, Yuting; Heng, Jian; Han, Ge; Wang, Pengfei; Zhao, Zhihua; Shi, Ming; Li, Juan; Wang, Jiazhen; Wu, Yixia; Liu, Feng; Xi, Jianzhong Jeff; Wang, Yangming; Zhang, Qiangfeng Cliff
Nature Genetics
Localized, highly efficient secretion of signaling proteins by migrasomes
Jiao, Haifeng; Li, Xiaopeng; Li, Ying; Guo, Yuting; Hu, Xiaoyu; Sho, Takami; Luo, Yiqun; Wang, Jinyu; Cao, Huizhen; Du, Wanqing; Li, Dong; Yu, Li
Cell Research
Structural insights into human exon-defined spliceosome prior to activation
Zhang, Wenyu; Zhang, Xiaofeng; Zhan, Xiechao; Bai, Rui; Lei, Jianlin; Yan, Chuangye; Shi, Yigong
Cell Research
An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms
Sun, Wenbo; Yang, Tingyu; Sun, Fengming; Liu, Panhong; Gao, Ji; Lan, Xianmei; Xu, Wei; Pang, Yuhong; Li, Tong; Li, Cuifeng; Liang, Qingtai; Chen, Haoze; Liu, Xiaohang; Tan, Wenting; Zhu, Huanhuan; Wang, Fang; Cheng, Fanjun; Zhai, Weiwei; Kim, Han-Na; Zhang, Jingren; Zhang, Linqi; Lu, Lu; Xi, Qiaoran; Deng, Guohong; Huang, Yanyi; Jin, Xin; Chen, Xiangjun; Liu, Wanli
Nature Immunology
Programmable in vitro and in vivo folding of single-stranded nucleic-acid wireframe origami
Zhang, Tianqing; Qian, Xinmin; Cui, Huangchen; Li, Qingting; Du, Xinyu; Fu, Xiaoyu; Gu, Hongzhou; Zeng, Wenwen; Wei, Bryan
Chem
A dual role of ERGIC-localized Rabs in TMED10-mediated unconventional protein secretion
Sun, Yuxin; Tao, Xuan; Han, Yaping; Lin, Xubo; Tian, Rui; Wang, Haodong; Chang, Pei; Sun, Qiming; Ge, Liang; Zhang, Min
Nature Cell Biology
Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators
Liu, Bofeng; He, Yuanlin; Wu, Xiaotong; Lin, Zili; Ma, Jing; Qiu, Yuexin; Xiang, Yunlong; Kong, Feng; Lai, Fangnong; Pal, Mrinmoy; Wang, Peizhe; Ming, Jia; Zhang, Bingjie; Wang, Qiujun; Wu, Jingyi; Xia, Weikun; Shen, Weimin; Na, Jie; Torres-Padilla, Maria-Elena; Li, Jing; Xie, Wei
Nature Cell Biology
Neutrophil-derived migrasomes are an essential part of the coagulation system
Jiang, Dong; Jiao, Lin; Li, Qing; Xie, Renxiang; Jia, Haohao; Wang, Shihui; Chen, Yining; Liu, Siyuan; Huang, Dandan; Zheng, Jiajia; Song, Wenhao; Li, Ying; Chen, Jianfeng; Li, Jinsong; Ying, Binwu; Yu, Li
Nature Cell Biology
Conformational dynamics of CasX (Cas12e) in mediating DNA cleavage revealed by single-molecule FRET
Xing, Wenjing; Li, Danyuan; Wang, Wenjuan; Liu, Jun-Jie Gogo; Chen, Chunlai
Nucleic Acids Research
RASP v2.0: an updated atlas for RNA structure probing data
Mu, Kunting; Fei, Yuhan; Xu, Yiran; Zhang, Qiangfeng Cliff
Nucleic Acids Research
How variable progenitor clones construct a largely invariant neocortex
Shen, Zhongfu; Yang, Jiajun; Zhang, Qiangqiang; Wang, Kuiyu; Lv, Xiaohui; Hu, Xiaolin; Ma, Jian; Shi, Song-Hai
National Science Review
An RdDM-independent function of Pol V transcripts in gene regulation and plant defence
Yuan, Yuxiang; Liu, Yujie; Han, Lu; Li, Yan; Qi, Yijun
Nature Plants
Evolutional heterochromatin condensation delineates chromocenter formation and retrotransposon silencing in plants
Zhang, Weifeng; Cheng, Lingling; Li, Kuan; Xie, Leiming; Ji, Jinyao; Lei, Xue; Jiang, Anjie; Chen, Chunlai; Li, Haitao; Li, Pilong; Sun, Qianwen
Nature Plants
An end-to-end framework for the prediction of protein structure and fitness from single sequence
Chen, Yinghui; Xu, Yunxin; Liu, Di; Xing, Yaoguang; Gong, Haipeng
Nature Communications
In situ structural determination of cyanobacterial phycobilisome-PSII supercomplex by STAgSPA strategy
Zhang, Xing; Xiao, Yanan; You, Xin; Sun, Shan; Sui, Sen-Fang
Nature Communications
Primase promotes the competition between transcription and replication on the same template strand resulting in DNA damage
Zhang, Weifeng; Yang, Zhuo; Wang, Wenjie; Sun, Qianwen
Nature Communications
Structural mechanism of bacteriophage lambda tail's interaction with the bacterial receptor
Ge, Xiaofei; Wang, Jiawei
Nature Communications
High-resolution and programmable RNA-IN and RNA-OUT genetic circuit in living mammalian cells
Zhang, Min; Zhang, Xue; Xu, Yongyue; Xiang, Yanhui; Zhang, Bo; Xie, Zhen; Wu, Qiong; Lou, Chunbo
Nature Communications
