陈晔光 博士
教授 中国科学院院士 发展中国家科学院院士
1979-1983 江西大学生物系，生物学学士
1983-1986 江西大学生物系，动物学硕士
1988-1990 美国福特汉姆大学，细胞生物学硕士
1991-1996 美国爱因斯坦医学院，细胞生物学博士
1996-2000 美国霍华德·休斯医学研究所斯隆-凯特琳癌症中心，博士后
2000-2002 美国加州大学河滨分校，助理教授
2002 -至今 清华大学生命科学学院，教授、博导
● 研究兴趣、领域：
主要运用分子生物学、细胞生物学、生物信息学等多学科手段，通过类器官技术和动物模型等研究成体干细胞自我更新和分化的机制，并探索相关疾病发生发展的机理。同时研究TGF-β和Wnt信号调控细胞命运的分子机制和生理病理功能。
● 代表性论文：
1）Wang YL, Lou RY, Zhang Z, Xiao CY, Yu SC, Wei ST, Liu Y, Fu W, Li BJ, Chen YG#. (2023) Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17, Science Advances. In press.
2）Liu LS, Wang YL, Yu SC, Liu HD, Li YH, Hua S, Chen YG#. (2023) TGF-β promotes inflammation and tumorigenesis in Smad4-deficient intestinal epithelium in a YAP-dependent manner, Advanced Science, e2300708.
3）Kang KX, Shi QN, Wang X, Chen YG#. (2022) Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly, Journal of Cell Biology, 221(12):e202205069.
4）Zhao LZ, Song WL, Chen YG#. (2022) Mesenchymal-epithelial interaction regulates gastrointestinal tract development in mouse embryos. Cell Reports, 40(2):111053.
5）Wang T, Zhang N, Fan SP, Zhao LZ, Song WL, Gong YH, Shen Q, Zhang C, Ren P, Lin CT, Fu W, Gao G, Ma SH#, Bi YH#, Chen YG#. (2021) Establishment of human distal lung organoids for SARS-CoV-2 infection. Cell Discovery, 7(1):108.
6）Nong JX, Kang KX, Shi QN, Zhu XC, Tao QH, Chen YG#. (2021) Phase separation of Axin organizes the β-catenin destruction complex. Journal of Cell Biology, 220(4): e202012112.
7）Wang YL, Song WL, Wang JL, Wang T, Xiong XC, Qi Z, Fu W#, Yang XR#, Chen YG#. (2020) Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine. Journal of Experimental Medicine, 217(2). pii: e20191130.
8）Liao HW, Li X, Zhao LZ, Wang YL, Wang XD, Wu Y, Zhou X, Fu W, Liu L, Hu HG#, Chen YG#. (2020) A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer. Cell Discovery, 6(35):1.
9）Li YZ, Liu Y, Y. Jeffrey Chiang, Huang F, Li YH, Li XT,Ning YH, Zhang WH, Deng HT, Chen YG#. (2019) DNA Damage Activates TGF-β Signaling via ATM-c-Cbl-Mediated Stabilization of the Type II Receptor TβRII. Cell Reports, 28(3):735.
10）Huang F, Shi QN, Li Y, Xu L, Xu C, Chen F, Wang H, Liao H, Chang Z, Liu F, Zhang XH, Feng XH, Han JJ, Luo S, Chen YG#. (2018) HER2/EGFR-AKT signaling switches TGF-β from inhibiting cell proliferation to promoting cell migration in breast cancer. Cancer Research, 78(21):6073.
11）Qi Z, Li YH, Zhao B, Xu C, Liu Y, Li H, Zhang B, Wang X, Yang X, Xie W, Li B, Han J, Chen YG#. (2017) BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes. Nature Communications, 8:13824.
12）Zhao B, Qi Z, Li Y, Wang C, Fu W, Chen YG#. (2015) Non-muscle-myosin-II mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells via the Rac1-PAK1-Akt axis. Nature Communications, 6:7166.
13）Zuo W, Huang F, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng XH, Luo S, Gao C, Chen YG#. (2013) c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor. Molecular Cell, 49(3):499.
14）Li ZW, Fei T, Zhang JP, Zhu GY, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG#. (2012) BMP4 Signaling Acts via Dual Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells. Cell Stem Cell, 10:171.
15）Gao C, Cao WP, Bao L, Zuo W, Xie GM, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG#. (2010) Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nature Cell Biology，12(8):781.
● 荣誉、奖励及参加学术团体的情况：
现任Cell Regeneration杂志主编、亚太细胞生物学组织理事长、国际细胞生物学联盟副理事长以及Cell Research、Cell Discovery、Open Biology、Cancer Sciences、Journal of Cellular and Molecular Medicine等期刊编委。
● 联系方式：
电话：010-62784794
E-mail：ygchen@tsinghua.edu.cn
