张伟  博士

副教授   

2000-2004年 山东大学生命科学学院     学士

2004-2010年 中国科学院神经科学研究所     博士

2010-2016年 加州大学旧金山分校/霍华德休斯医学院     博士后

2017年至今   清华大学生命科学学院      助理教授、副教授    

2017年至今   清华大学生命联合中心/清华-IDG/麦戈文脑科学研究院    研究员                          

 

●  研究兴趣、领域：

大脑与体内器官的双向交流由复杂的神经和激素系统控制，对维持人体的生理和心理稳态起着至关重要的作用。体内感受不仅广泛参与本能行为的调控，还会影响高级认知行为，例如记忆、情绪和自我意识。我们实验室采用“受体的生物物理学--神经元的细胞生物学—神经环路的功能学—动物行为学”这一自下而上的模式，探讨体内感受的分子与神经环路机制, 并进行神经-器官双向通讯与生理调控的多维度研究。

●  代表性论文：

1. Chenxi Liu*, Ning Tian, Pei Chang, Wei Zhang*. Mating reconciles fitness and fecundity by switching diet preference in flies. Nature Communications.2024.

2. Jierui Qin, Tingting Yang, Kexin Li，Ting Liu, Wei Zhang*. Pharyngeal mechanosensory neurons control food swallow in Drosophila melanogaster. eLife,2024.

3. Jie Yu, Xuan Guo, Shen Zheng, Wei Zhang*. A dedicate sensorimotor circuit enables fine texture discrimination by active touch. Plos Genetics.2023

4. Chenxi Liu*, Wei Zhang*. Molecular basis of somatosensation in insects. Current Opinion in Neurobiology, 2022

5. Yinjun Jia*, Shuaishuai Li, Xuan Guo, Bo Lei, Junqiang Hu, Xiao-Hong Xu, Wei Zhang*, Selfee, self-supervised features extraction of animal behaviors. Elife, 2022

6. Liwei Zhang*#, Xuan Guo#, Wei Zhang*. Nutrients and pheromones promote insulin release to inhibit courtship drive. Science Advances. 2022

7. Tingting Yang, Zixuan Yuan, Chenxi Liu, Ting Liu, Wei Zhang*. A neural circuit integrates pharyngeal sensation to control feeding. Cell Reports. 2021.

8. Rui Luo, Yuxiang Zhang, Yinjun Jia, Yan Zhang, Zongyang Li, Jieqing Zhao, Ting Liu, Wei Zhang*. Molecular basis and homeostatic regulation of Zinc taste. Protein & Cell. 2021.

9. Philip Hehlert, Wei Zhang, Martin C Göpfert, Drosophila Mechanosensory Transduction, Trends in Neurosciences, Volume 44, Issue 4, 323 - 335

10. Pingping Wang, Yinjun Jia, Ting Liu, Yuh-Nung Jan*, Wei Zhang*. Visceral Mechano-sensing Neurons Control Drosophila Feeding by Using Piezo as a Sensor. Neuron. 2020.

11. Chenxi Liu, Bei Zhang, Liwei Zhang, Tingting Yang, Zhewei Zhang, Zihua Gao, Wei Zhang. A neural circuit encoding mating states tunes defensive behavior in Drosophila. Nature Communications. 2020.

12. Liwei Zhang#*, Jie Yu#, Xuan Guo, Jianhua Wei, Ting Liu, Wei Zhang*. Parallel mechanosensory pathways direct oviposition decision of Drosophila. Current Biology. 2020.

13. Yawen Li #, Yufei Hu#, Jiawei Wang, Xin Liu*, Wei Zhang*; Linfeng Sun*. Structural Insights into a Plant Mechanosensitive Ion Channel MSL1. Cell Reports. 2020.

14. Yufei Hu, Zhilin Wang, Ting Liu, Wei Zhang*. Piezo-like Gene Regulates Locomotion in Drosophila Larvae. Cell Reports. 2019.

 

●  联系方式：

Tel: +86-10-62790589

E-mail:  weizhang0505@126.com