张伟 博士
副教授
2000-2004年 山东大学生命科学学院 学士
2004-2010年 中国科学院神经科学研究所 博士
2010-2016年 加州大学旧金山分校/霍华德休斯医学院 博士后
2017年至今 清华大学生命科学学院 助理教授、副教授
2017年至今 清华大学生命联合中心/清华-IDG/麦戈文脑科学研究院 研究员
● 研究兴趣、领域：
大脑与体内器官的双向交流由复杂的神经和激素系统控制，对维持人体的生理和心理稳态起着至关重要的作用。体内感受不仅广泛参与本能行为的调控，还会影响高级认知行为，例如记忆、情绪和自我意识。我们实验室采用“受体的生物物理学--神经元的细胞生物学—神经环路的功能学—动物行为学”这一自下而上的模式，探讨体内感受的分子与神经环路机制, 并进行神经-器官双向通讯与生理调控的多维度研究。
● 代表性论文：
1. Yinjun Jia#，Bowen Gao#，Jiaxin Tan#，Jiqing Zheng#，Xin Hong，Wenyu Zhu ，Haichuan Tan，Yuan Xiao，Liping Tan，Hongyi Cai，Yanwen Huang，Zhiheng Deng，Xiangwei Wu，Yue Jin，Yafei Yuan，Jiekang Tian，Wei He，Weiying Ma，Yaqin Zhang，Lei Liu*，Chuangye Yan*，Wei Zhang*，Yanyan Lan*.Deep contrastive learning enables genome-wide virtual screening. Science.2026
2. Kexin Li#，Yue Jin#，Ting Liu, Hongkun Shan，Yi Lin，Wei Zhang*. Brain-gonad axes harmonize male mating drive and reproductive strategy via steroid hormones. Nature Communications.2025.
3. YanyanShi*，Yinjun Jia，Wei Zhang*. Molecular and neural basis of vomiting behavior in Drosophila melanogaster. Science Advances. 2025
4. Chenxi Liu*, Ning Tian, Pei Chang, Wei Zhang*. Mating reconciles fitness and fecundity by switching diet preference in flies. Nature Communications.2024.
5. Jierui Qin, Tingting Yang, Kexin Li，Ting Liu, Wei Zhang*. Pharyngeal mechanosensory neurons control food swallow in Drosophila melanogaster. eLife,2024.
6. Jie Yu, Xuan Guo, Shen Zheng, Wei Zhang*. A dedicate sensorimotor circuit enables fine texture discrimination by active touch. Plos Genetics.2023
7. Chenxi Liu*, Wei Zhang*. Molecular basis of somatosensation in insects. Current Opinion in Neurobiology, 2022.
8. Yinjun Jia*, Shuaishuai Li, Xuan Guo, Bo Lei, Junqiang Hu, Xiao-Hong Xu, Wei Zhang*. Selfee, self-supervised features extraction of animal behaviors. eLife, 2022.
9. Liwei Zhang*#, Xuan Guo*#, Wei Zhang*. Nutrients and pheromones promote insulin release to inhibit courtship drive. Science Advances. 2022
10. Tingting Yang, Zixuan Yuan, Chenxi Liu, Ting Liu, Wei Zhang*. A neural circuit integrates pharyngeal sensation to control feeding. Cell Reports. 2021.
11. Rui Luo, Yuxiang Zhang, Yinjun Jia, Yan Zhang, Zongyang Li, Jieqing Zhao, Ting Liu, Wei Zhang*. Molecular basis and homeostatic regulation of Zinc taste. Protein & Cell. 2021.
12. Pingping Wang, Yinjun Jia, Ting Liu, Yuh-Nung Jan*, Wei Zhang*. Visceral Mechano-sensing Neurons Control Drosophila Feeding by Using Piezo as a Sensor. Neuron. 2020.
13. Chenxi Liu, Bei Zhang, Liwei Zhang, Tingting Yang, Zhewei Zhang, Zihua Gao. Wei Zhang*.A neural circuit encoding mating states tunes defensive behavior in Drosophila. Nature Communications. 2020.
14. Liwei Zhang#*, Jie Yu#, Xuan Guo, Jianhua Wei, Ting Liu, Wei Zhang*. Parallel mechanosensory pathways direct oviposition decision of Drosophila. Current Biology. 2020.
15. Yawen Li#, Yufei Hu#, Jiawei Wang, Xin Liu*, Wei Zhang*; Linfeng Sun*. Structural Insights into a Plant Mechanosensitive Ion Channel MSL1. Cell Reports. 2020.
● 联系方式：
Tel: +86-10-62790589
E-mail: weizhang0505@126.com
