杨雪瑞 博士

教授

1999-2003  清华大学，化学工程系，学士
2003-2009  美国密歇根州立大学，化学工程系/生物化学及分子生物学系，双学科博士
2009-2012  美国哥伦比亚大学，Irving癌症研究中心，系统生物学联合中心，博士后
2012-至今  清华大学生命科学学院，助理教授、副教授、教授

●  研究兴趣、领域：

生物信息学与RNA生物学：针对转录后RNA加工、翻译与非编码RNA调控等过程，开发新的生物信息与人工智能算法，通过复杂生命组学数据的深度挖掘与分子、细胞生物学机制研究，解析生理与病理状态下遗传信息多层级传递与调控的过程与机制，鉴定RNA干预靶点，指导RNA生物学过程的人工设计与改造。主要研究方向：

1. 多模态、跨尺度、复杂生命组学数据的人工智能挖掘策略；

2. 时空解析度下RNA转录后加工、定位、翻译过程的耦合与细胞特异性调控；

3. 非编码转录组生理功能的系统鉴定与分子机制解析；

4. 肿瘤等复杂疾病的RNA干预靶点鉴定与功能性人工RNA分子设计

实验室网站：labyang.com

●  代表性论文：

1. Kang, Z., Li, R., Liu, C., Dong, X., Hu, Y., Xu, L., Liu, X., Xiang, Y., Gao, L., Si, W., Wang, L., Li, Q., Zhang, L., Wang, H., Yang, X.*, and Liu, J.*, m6A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells. Cell, 2024. 187(21).

2. Li, R., Chen, X., and Yang, X.*, Navigating the Landscapes of Spatial Transcriptomics: How Computational Methods Guide the Way. Invited Review. WIREs RNA, 2024. 15(2):e1839.

3. Xiang, X., He, Y., Zhang, Z., and Yang, X.*, Interrogations of single-cell RNA splicing landscapes with SCASL define new cell identities with physiological relevance. Nat Commun, 2024. 15(1): p. 2164.

4. Zhuang, Y., Li, Z., Xiong, S., Sun, C., Li, B., Wu, S.A., Lyu, J., Shi, X., Yang, L., Chen, Y., Bao, Z., Li, X., Sun, C., Chen, Y., Deng, H., Li, T., Wu, Q., Qi, L., Huang, Y., Yang, X.*, and Lin, Y.*, Circadian clocks are modulated by compartmentalized oscillating translation. Cell, 2023. 186(15): p. 3245-3260.

5. Li, F., Fang, J., Yu, Y., Hao, S., Zou, Q., Zeng, Q., and Yang, X.*, Reanalysis of ribosome profiling datasets reveals a function of rocaglamide A in perturbing the dynamics of translation elongation via eIF4A. Nat Commun, 2023. 14(1): p. 553.

6. Hu, X., Zou, Q., Yao, L., and Yang, X.*, Survey of the binding preferences of RNA-binding proteins to RNA editing events. Genome Biol, 2022. 23(1): p. 169.

7. Li, R. and Yang, X.*, De novo reconstruction of cell interaction landscapes from single-cell spatial transcriptome data with DeepLinc. Genome Biol, 2022. 23(1): p. 124.

8. Wang, Y., Zou, Q., Li, F., Zhao, W., Xu, H., Zhang, W., Deng, H., and Yang, X.*, Identification of the cross-strand chimeric RNAs generated by fusions of bi-directional transcripts. Nat Commun, 2021. 12(1): p. 4645.

9. Wang, X., Hu, X., Song, W., Xu, H., Xiao, Z., Huang, R., Bai, Q., Zhang, F., Chen, Y., Liu, Y., Fang, J., Li, X., Shen, Q., Zhao, H., and Yang, X.*, Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation. Cell Res, 2021. 31(6): p. 664-683.

10. Xu, F., Du, W., Zou, Q., Wang, Y., Zhang, X., Xing, X., Li, Y., Zhang, D., Wang, H., Zhang, W., Hu, X., Liu, X., Liu, X., Zhang, S., Yu, J., Fang, J., Li, F., Zhou, Y., Yue, T., Mi, N., Deng, H., Zou, P., Chen, X., Yang, X.*, and Yu, L.*, COPII mitigates ER stress by promoting formation of ER whorls. Cell Res, 2021. 31(2): p. 141-156.

11. Zhu, M., Zou, Q., Huang, R., Li, Y., Xing, X., Fang, J., Ma, L., Li, L., Yang, X.*, and Yu, L.*, Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells. Cell Res, 2021. 31(2): p. 237-240.

12. Lin, Y., Li, F., Huang, L., Polte, C., Duan, H., Fang, J., Sun, L., Xing, X., Tian, G., Cheng, Y.*, Ignatova, Z., Yang, X.*, and Wolf, D.A.*, eIF3 Associates with 80S Ribosomes to Promote Translation Elongation, Mitochondrial Homeostasis, and Muscle Health. Mol Cell, 2020. 79(4): p. 575-587 e7.

13. Wu, Y., Zhao, W., Liu, Y., Tan, X., Li, X., Zou, Q., Xiao, Z., Xu, H., Wang, Y., and Yang, X.*, Function of HNRNPC in breast cancer cells by controlling the dsRNA-induced interferon response. EMBO J, 2018. 37(23).

14. Li, X., Wang, X., Song, W., Xu, H., Huang, R., Wang, Y., Zhao, W., Xiao, Z., and Yang, X.*, Oncogenic Properties of NEAT1 in Prostate Cancer Cells Depend on the CDC5L-AGRN Transcriptional Regulation Circuit. Cancer Res, 2018. 78(15): p. 4138-4149.

15. Xiao, Z., Huang, R., Xing, X., Chen, Y., Deng, H., and Yang, X.*, De novo annotation and characterization of the translatome with ribosome profiling data. Nucleic Acids Res, 2018. 46(10): p. e61.

●  联系方式：

电话：+86-10-62783943
E-mail：yangxuerui@tsinghua.edu.cn