王一国 博士
副教授
1997.9－2001.7 曲阜师范大学生命科学学院 学士
2001.9－2007.1 中科院上海生物化学与细胞生物学研究所 博士
2007.8－2012.8 美国索儿克研究所 博士后
2012.8－ 清华大学生命科学学院 助理教授、副教授
● 研究兴趣、领域：
能量过剩引发的代谢性疾病，如肥胖、糖尿病、心脑血管疾病及肿瘤，已成为我国乃至全球亟待解决的重大社会问题。激素在维持能量平衡中发挥关键调控作用，鉴定新的能够降低能量过剩的激素，对于缓解当前代谢性疾病的治疗困境具有重要意义。本实验室已发现多种新型激素，研究将重点围绕抑制能量摄入、减少能量储存及增强能量消耗的激素展开，系统解析其分子机制，优化功能特性，并探索其在代谢性疾病治疗中的临床转化潜力。
● 代表性论文：
1. Aijun Long, Yazhuo Wang, Yihua Guo, Jie Hong, Guang Ning, Zhuoxian Meng*, Jiqiu Wang*, Yiguo Wang*. (2025) A famsin-glucagon axis mediates glucose homeostasis. Cell Metab. 37, 629-639.
2. Xiaoliu Shi#, Xiao Hu#, Xinlei Fang#, Liangjie Jia, Fangchao Wei, Ying Peng, Menghao Liu, Aibo Gao, Ke Zhao, Fengyi Chen, Xiaoli Hu, Jie Hong, Guang Ning, Yongfeng Song*, Jiqiu Wang*, Yiguo Wang*. (2025) A feeding-induced myokine modulates glucose homeostasis. Nature Metab. 7, 68-83. (Cover article)
3. Ying Peng#, Liangjie Jia#, Xiao Hu, Xiaoliu Shi, Xinlei Fang, Yifu Qiu, Zhenji Gan, Yiguo Wang*. (2025) Cellular Feimin enhances exercise performance by suppressing muscle thermogenesis. Nature Metab. 7, 84-101. (Cover article)
4. Xiaoli Hu#, Fengyi Chen#, Liangjie Jia, Aijun Long, Ying Peng, Xu Li, Junfeng Huang, Xueyun Wei, Xinlei Fang, Zihua Gao, Mengxian Zhang, Xiao Liu, Ye-Guang Chen, Yan Wang, Huijie Zhang*, Yiguo Wang*. (2024) A gut-derived hormone regulates cholesterol metabolism. Cell 187, 1685-1700. (Cell Best of 2024)
5. Aijun Long#, Yang Liu#, Xinlei Fang, Liangjie Jia, Zhiyuan Li, Jiang Hu, Shuang Wu, Chao Chen, Ping Huang*, Yiguo Wang*. (2023) Famsin, a novel gut-secreted hormone, contributes to metabolic adaptations to fasting via binding to its receptor OLFR796. Cell Res. 33, 273-287. (Cover article)
6. Erwei Li#, Haili Shan#, Liqun Chen#, Aijun Long#, Yuanyuan Zhang#, Yang Liu, Liangjie Jia, Fangchao Wei, Jinbo Han, Tong Li, Xiaohui Liu, Haiteng Deng, Yiguo Wang*. (2019) OLFR734 mediates glucose metabolism as a receptor of Asprosin. Cell Metab. 30, 319-328.
7. Liqun Chen#, Ke Wang#, Aijun Long, Liangjie Jia, Yuanyuan Zhang, Haiteng Deng, Yu Li, Jinbo Han, Yiguo Wang*. (2017) Fasting-induced hormonal regulation of lysosomal function. Cell Res. 27, 748-763.
8. Jinbo Han#, Erwei Li#, Liqun Chen, Yuanyuan Zhang, Fangchao Wei, Jieyuan Liu, Haiteng Deng, Yiguo Wang*. (2015) The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. Nature 524, 243-246.
9. Yiguo Wang, Gang Li, Jason Goode, Jose C. Paz, Kunfu Ouyang, Robert Screaton, Wolfgang H. Fischer, Ju Chen, Ira Tabas, Marc Montminy*. (2012) InsP3 receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature 485, 128-132.
10. Yiguo Wang, Liliana Vera, Wolfgang H Fischer, Marc Montminy*. (2009) The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 460, 534-537.
● 联系方式：
电话：+86-10-62783209
E-mail: yiguo@mail.tsinghua.edu.cn
