王一国 博士

副教授

1997.9－2001.7       曲阜师范大学生命科学学院 学士

2001.9－2007.1       中科院上海生物化学与细胞生物学研究所     博士

2007.8－2012.8       美国索儿克研究所   博士后

2012.8－                  清华大学生命科学学院  副教授

●  研究兴趣、领域：

糖脂代谢稳态的激素信号调控：

1. 高等生物特有新激素的发现；

2. 新激素对糖脂代谢稳态的调控；

3. 新激素在代谢性疾病中的作用。

●  代表性论文：

1. Xiaoli Hu^#, Fengyi Chen^#, Liangjie Jia, Aijun Long, Ying Peng, Xu Li, Junfeng Huang, Xueyun Wei, Xinlei Fang, Zihua Gao, Mengxian Zhang, Xiao Liu, Ye-Guang Chen, Yan Wang, Huijie Zhang*, Yiguo Wang*. (2024) A gut-derived hormone regulates cholesterol metabolism. Cell 187, 1685-1700.

2. Aijun Long^#, Yang Liu^#, Xinlei Fang, Liangjie Jia, Zhiyuan Li, Jiang Hu, Shuang Wu, Chao Chen, Ping Huang* and Yiguo Wang*. (2023) Famsin, a novel gut-secreted hormone, contributes to metabolic adaptations to fasting via binding to its receptor OLFR796. Cell Res. 33, 273-287. (Cover article)

3. Yi Liu^#, Yuanyuan Zhang^#, Tong Li, Jinbo Han and Yiguo Wang*. (2020) The tight-junction protein TJP1 regulates the feeding-modulated hepatic circadian clock. Nat Commun. 11(1), 589.

4. Erwei Li^#, Haili Shan^#, Liqun Chen^#, Aijun Long^#, Yuanyuan Zhang^#, Yang Liu, Liangjie Jia, Fangchao Wei, Jinbo Han, Tong Li, Xiaohui Liu, Haiteng Deng and Yiguo Wang*. (2019) OLFR734 mediates glucose metabolism as a receptor of Asprosin. Cell Metab. 30, 319-328.

5. Liqun Chen^#, Ke Wang^#, Aijun Long, Liangjie Jia, Yuanyuan Zhang, Haiteng Deng, Yu Li, Jinbo Han and Yiguo Wang*. (2017) Fasting-induced hormonal regulation of lysosomal function. Cell Res. 27, 748-763.

6. Jinbo Han^#, Erwei Li^#, Liqun Chen, Yuanyuan Zhang, Fangchao Wei, Jieyuan Liu, Haiteng Deng and Yiguo Wang*. (2015). The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. Nature 524, 243-246.

7. Yiguo Wang, Gang Li, Jason Goode, Jose C. Paz, Kunfu Ouyang, Robert Screaton, Wolfgang H. Fischer, Ju Chen, Ira Tabas and Marc Montminy*. (2012). InsP3 receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature 485, 128-132.

8. Yiguo Wang, Hiroshi Inoue, Kim Ravnskjaer, Kristin Viste, Nina Miller, Yi Liu, Susan Hedrick, Liliana Vera, and Marc Montminy*. (2010). Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. Proc Natl Acad Sci U S A. 107, 3087-3092.

9. Yiguo Wang, Liliana Vera, Wolfgang H Fischer, Marc Montminy*. (2009). The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 460, 534-537.

10. Yiguo Wang, Dan Du, Longhou Fang, Guang Yang, Chenyi Zhang, Rong Zeng, Axel Ullrich, Friedrich Lottspeich, Zhengjun Chen*.  Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling.  The EMBO Journal. (2006) 25, 5058-5070.

●  联系方式：

电话：+86-10-62783209

E-mail: yiguo@mail.tsinghua.edu.cn