刘念 博士
副教授
2010年／中国科学技术大学／学士
2015年／芝加哥大学／博士
2015-2019年／斯坦福大学／博士后
2019年-2022年／清华大学生命科学学院-生命科学联合中心／助理教授
2022年-至今／清华大学生命科学学院-生命科学联合中心／副教授
● 研究兴趣、领域：
转座子是可以移动（或转座）的DNA，存在于几乎所有的生命体中，属于基因组中的“暗物质”。转座子在人体内大量富集，占据大约一半的人体DNA，并且仍然具有转座活性。人体转座子的活性与胚胎发育、神经发育以及上百种疾病密切相关，但是其相关机理和功能至今不是非常清楚。我们利用分子、细胞、生化、高通量测序和生统筹手段主攻转座子活性是如何被调控的机理，及其在发育和疾病中的具体功能。此外，我们还在积极探索RNA调控功能的未知领域。
● 代表性论文：
1. Zhang T*, Li X*, Zhou W, Li Z, Bi J, Ma X, Li X, Fan Y, Hong Y, Wang S, Wang Y, Yang L, Chen Y, Qin W, Wang H, Xi Q, Shi S, Liu N#. ANKRD11 condensates restrict hypertranscribed genes to safeguard development. Cell (2026) https://www.cell.com/cell/fulltext/S0092-8674(26)00804-4
2. Zhou Z*, Zhu S*, Hong Y, Jin G, Ma R, Lin F, Zhang Y, Lee HY#, Liu N#. Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation. Cell (2025) https://www.cell.com/cell/fulltext/S0092-8674(25)00803-7
3. Li X*, Bie L*, Wang Y*, Hong Y*, Zhou Z, Fan Y, Yan X, Tao Y, Huang C, Zhang Y, Sun X, Li J, Zhang J, Chang Z, Xi Q, Meng A, Shen X, Xie W, Liu N#. LINE-1 transcription activates long-range gene expression. Nature Genetics (2024) https://www.nature.com/articles/s41588-024-01789-5
4. Hong Y*, Bie L*, Zhang T*, Yan X, Jin G, Chen Z, Wang Y, Li X, Pei G, Zhang Y, Hong Y, Gong L, Li P, Xie W, Zhu Y, Shen X, Liu N#. SAFB restricts contact domain boundaries associated with L1 chimeric transcription. Molecular Cell (2024) https://doi.org/10.1016/j.molcel.2024.03.021
5. Li X, Liu N#. Advances in understanding LINE-1 regulation and function in the human genome. Trends in Genetics (2025). ISSN 0168-9525. [Cover article & Featured Article] https://www.cell.com/trends/genetics/fulltext/S0168-9525(25)00103-9
6. Hong Y, Liu N#. Transposable elements in health and disease: molecular basis and clinical implications. Chinese Medical Journal (2025) https://journals.lww.com/cmj/fulltext/9900/transposable_elements_in_health_and_disease_.1694.aspx
7. Liu, N.*, Lee, C.*, Swigut, T., Grow, E., Gu, B., Bassik, M.#, and Wysocka, J#. Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators. Nature 553, 228-232 (2018).
8. Liu, N., Dai, Q., Zheng, G., He, C., Parisien, M.#, Pan, T#. N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions. Nature 518, 560-564 (2015).
9. Liu, N.*, Pan, T.* N6-methyladenosine-coded RNA Epigenetics. Nat. Struct. Mol. Biol. 23, 98-102 (2016).
10. Liu, N.*, Zhou, K.*, Parisien, M., Dai, Q., Diatchenko, L., and Pan, T#. N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein. Nucleic Acids Res. 45 (10), 6051-6063 (2017).
11. Liu, N., Parisien, M., Dai, Q., Zheng, G., He, C., and Pan, T#. Probing N6-methyl-adenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA. RNA 19, 1848-1856 (2013).
● 荣誉、奖励及参加学术团体的情况：
Benyuan Fund – Young Investigator Exploration Fellowship in Life Sciences (2024)
Bayer Investigator Award (2020)
Jane Coffin Child Foundation Fellowship (2016-2019)
RNA Society / Scaringe Graduate Student Award (2016)
Award for Outstanding Self-financed Students Abroad (2016)
Aldrich Alfred R. Bader Award for Student Innovation (2015)
● 联系方式：
实验室网页：http://liulab.life.tsinghua.edu.cn/
邮箱：liunian88@tsinghua.edu.cn
通讯地址：北京市清华大学生命科学学院，刘念实验室 100084
