陈国强 博士
教授
1981-1985 广州华南理工大学，学士
1986-1989 奥地利格拉茨工业大学，博士
1990-1992 英国诺丁汉大学，博士后
1992-1994 加拿大阿尔伯达大学，博士后
1994-1997 清华大学生命科学学院，副教授
1997-至今 清华大学生命科学学院，教授、博导
● 研究兴趣、领域：
合成生物学、微生物代谢工程、生物材料、工业生物技术
● 代表性论文：
1. Yiling Chen, Xu Liu, Lizhan Zhang Jishuai Yang, Weike Guo, Shuang Zheng, Jiale Wang, Fuqing Wu, Xu Yan, Qiong Wu, Chen GQ. Cell Sizes Matter for Industrial Bioproduction, A Case of Polyhydroxybutyrate. Advanced Science 2025, 2412256 (DOI: 10.1002/advs.202412256)
2. Zonghao Zhang, Shuang Zheng, Zhongnan Zhang, Fuqing Wu, Qiong Wu, Chen GQ. Lactose Induced Bioproduction by Halomonas Grown under Open Conditions. Chemical Engineering Journal 507 (2025) 160468 https://doi.org/10.1016/j.cej.2025.160468
3. Shuang Zheng, Mingwei Shao, Wanze Wang, Chen GQ. Next-generation biotechnology inspired by extremes. EMBO Reports 27 (2025) 1-5 (DOI:10.1038/s44319-025-00389-6)
4. Yiping Yuan，Huan Wang，Hongtao He，Zhongnan Zhang，Fang Yang， Yiling Chen, Fuqing Wu, Qiong Wu, Chen GQ. Polyhydroxyalkanoate Production by Engineered Halomonas Grown in Lignocellulose Hydrolysate. Bioresource Technology 425 (2025) 132313 (doi.org/10.1016/j.biortech.2025.132313)
5. Hongtao He, Ng Wuh Jer, Qitiao Hu, Zhongnan Zhang, Simian Sun, Geyuan Xu, Shimao Yang, Shuang Zheng, Xu Liu, Qiong Wu*, Chen GQ*. Engineering Halomonas bluephagenesis for Pilot Production of Terpolymers (3-Hydroxybutyrate, 4-Hydroxybutyrate and 3-Hydroxyvalerate) from Glucose. Metabolic Engineering 90 (2025) 117-128 (https://doi.org/10.1016/j.ymben.2025.03.003)
6. Xu Liu, Helen Park, Yannic Sebastian Ackermann, Luc Avérous, Hendrik Ballerstedt, Werner Besenmatter, Blas Blázquez, Uwe T. Bornscheuer, Yannick Branson, William Casey, Víctor de Lorenzo, Weiliang Dong, Tilman Floehr, Manuel S. Godoy, Yu Ji, Andreas Jupke, Jürgen Klankermayer, David San León, Luo Liu, Xianrui Liu, Yizhi Liu, Maria T. Manoli, Esteban Martínez-García, Tanja Narancic, Juan Nogales, Kevin O’Connor, Ole Osterthun, Rémi Perrin, M. Auxiliadora Prieto, Eric Pollet, Alexandru Sarbu, Ulrich Schwaneberg, Haijia Su, Zequn Tang, Till Tiso, Zishuai Wang, Ren Wei, Gina Welsing, Nick Wierckx, Birger Wolter, Gang Xiao, Jianmin Xing, Yilin Zhao, Jie Zhou, Tianwei Tan, Lars M. Blank, Min Jiang, Guo-Qiang Chen. Exploring biotechnology for plastic recycling，degradation, and upcycling for a sustainable future. Biotechnology Advances 81 (2025) 108544 (doi.org/10.1016/j.biotechadv.2025.108544)
7. Yiling Chen, Weike Guo, Rou Wen, Guo-Qiang Chen. An Automatic Lytic System for Downstream Purification of PHA Produced by Halomonas. Chemical Engineering Journal. 517 (2025)164425 (https://doi.org/10.1016/j.cej.2025.164425)
8. Jiangnan Chen, Fang Yang, Xinyu Chen, Yiling Chen, Zhenghao Xu, Shi Mu, Guo-Qiang Chen*. Production and Characterization of Copolymers Consisting of 3-Hydroxybutyrate and Adjustable Lactate by Engineered Halomonas bluephagenesis from Glucose. Bioresource Technology 434 (2025) 132833 (https://doi.org/10.1016/j.biortech.2025.132833)
9. Mingwei Shao, Zhongnan Zhang, Xiaofan Jin, Ding Jun and Chen GQ. An Orthogonal Transcription Mutation System Generating All Transition Mutations for Accelerated Protein Evolution in vivo. Nature Communications (2025) 16: 6041 (DOI:10.1038/s41467-025-61354-4)
10. Jiale Wang, Xu Yan, Shuang Zheng, Rou Wen, Yiling Chen, Weinan Yang, Junting Sheng, Qiong Wu, Fuqing Wu, Guo-Qiang Chen. Biosynthesis of Poly(δ-valerolactone) (PVL) by Halomonas bluephagenesis. Chemical Engineering Journal 519 (2025) 165410 (doi.org/10.1016/j.cej.2025.165410)
11. Mengke Ji, Fang Yang, Zhongnan Zhang, Huan Wang, Te Gao, Yixin Gao, Yaoyao Zhang, Jinghui Wang, Qiong Wu, Fuqing Wu, Guo-Qiang Chen. Production of polyhydroxyalkanoate from acetate by metabolically engineered Halomonas bluephagenesis. Chemical Engineering Jornal 524 (2025) 168915 https://doi.org/10.1016/j.cej.2025.168915
12. Yuying Guan, Fang Yang, Cuihuan Zhao, Lizhan Zhang, Rou Wen, Fuqing Wu, Guo-Qiang Chen. CRISPR/AID-Mediated Multiplex Genome Editing in Halomonas spp.: A Robust Toolbox for Industrial Strain Development. Chemical Engineering Journal https://doi.org/10.1016/j.cej.2025.171411 526 (2025) 171411
13. Rou Wen, Yiling Chen, Jiale Wang, Weinan Yang, Yang Fang, Qiong Wu, Fuqing Wu, Xu Yan, Guo-Qiang Chen. Pilot production of P(3HB-co-4HB) by engineered Halomonas bluephagenesis harboring an endogeneous plasmid grown on glucose. Metabolic Engineering 94 (2025) 153-168 https://doi.org/10.1016/j.ymben.2025.11.017
14. Simian Sun, Shimao Yang, Yu Qiu, Jun Ding, Wanze Wang, Fuqing Wu, Guo-Qiang Chen. Life Cycle Design of Polyhydroxyalkanoates (PHA). National Science Review 12 (12) (2025) nwaf517 (DOI: 10.1093/nsr/nwaf517)
● 荣誉、奖励及参加学术团体的情况：
2023 国际代谢工程奖
2022 自然资源科学技术奖 科技进步奖
2021 吉林省科学技术奖 一等奖
2012 北京市科学技术奖 二等奖
2002 国家技术发明 二等奖
● 联系方式：
电话：010－62783844(办公室)
邮箱：chengq@tsinghua.edu.cn
