刘玉乐 博士

教授


1984.9-1988.7         天津南开大学生物化学专业 (学士)         
1990.9-1992.6         北京中国科学院微生物学研究所 (硕士)   
1994.9-1997.11       中国科学院微生物学研究所与英国苏格兰作物研究所联合培养博士
1988.8-1998.9         北京中国科学院微生物学研究所   实习,助理,副研究员,研究员
1995.5-1996.5         英国苏格兰作物研究所                访问学者
1998.9-1999.8         美国德克萨斯大学奥斯丁分校      博士后
1999.9-2002.8         美国耶鲁大学                       博士后
2002.9-2006.12       美国耶鲁大学                       Associate Research Scientist
2007.1 ---至今         清华大学                              教授,“百人计划”责任教授

●  研究兴趣、领域:


植物免疫的信号传导与调控、植物病毒病理的分子基础、植物细胞自噬、植物功能基因组。

 

●  代表性论文:


1. Li H, Zhang D, Xie K, Wang Y, Liao Q, Hong H, Liu Y*. Efficient and high-throughput pseudorecombinant-chimeric Cucumber mosaic virus-based VIGS in maize. Plant Physiology, 2021 (in press)

2. Wang Y, Gong Q, Wu Y, Huang F, Ismayil A, Zhang D, Li H, Gu H, Ludman M, Fátyol, Qi Y, Yoshioka K, Hanley-Bowdoin L, Hong Y, Liu Y*. A calmodulin-binding transcription factor links calcium signaling to antiviral RNAi defense in plants, Cell Host & Microbe 29, 1393–1406, 2021

3. Wang J, Han M, Liu Y*. Diversity, structure and function of the coiled-coil domains of plant NLR immune receptors. Journal of Integrative Plant Biology, 63(2):283-296, 2021

4. Yang M, Ismayil A, Liu Y*. Autophagy in plant-virus interactions, Annual Review of Virology, 7:403–19, 2020

5. Wang J, Chen T, Han M, Qian L, Li J, Wu M, Han T, Cao J, Nagalakshmi U, Rathjen JP, Hong Y, Liu Y*. Plant NLR immune receptor Tm-22 activation requires NB-ARC domain-mediated self-association of CC domain. PLoS Pathogens 16(4):e1008475, 2020

6. Ismayil A, Yang M, Haxima Y, Wang Y, Li J, Han L, Wang Y, Zheng X, Wei X, Nagalakshmi U, Hong Y, Hanley-Bowdoin L, Liu Y*. Cotton leaf curl Multan virus βC1 protein induces autophagy by disrupting the interaction of autophagy related protein 3 with Glyceraldehyde-3 Phosphate Dehydrogenases.Plant Cell.32(4):1124-1135, 2020

7.Ismayil A, Yang M, Liu Y*, Role of autophagy during plant-virus interactions, Seminars in Cell and Developmental Biology, 101: 36-40 2020

8.Zheng X, Wu M, Li X, Cao J, Li J, Wang J, Huang S, Liu Y*, Wang Y*, Actin filaments are dispensable for bulk autophagy in plants, Autophagy,15(12): 2126-2141, 2019

9.Wang Y, Wu Y, Gong Q, Ismayil1 A, Yuan Y, Lian B, Jia Q, Han M, Deng H, Hong Y, Hanley-Bowdoin L, Qi Y*, Liu Y*. Geminiviral V2 Protein Suppresses Transcriptional Gene Silencing through Interaction with AGO4. Journal of Virology 93(6): e01675-18 2019

10.Ismayil A, Haxim Y, Wang Y, Li H, Qian L, Han T, Chen T, Jia Q, Yihao Liu A, Zhu S, Deng H, Gorovits R, Hong Y, Hanley-Bowdoin L, Liu Y*. Cotton Leaf Curl Multan virus C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase. PLoS Pathogens 14(8): e1007282, 2018

11.Yang M, Zhang Y, Xie X, Yue N, Li J, Wang XB, Han CG, Yu JL, Liu Y*, Li D*. Barley Stripe Mosaic Virus γb Protein Subverts Autophagy to Promote Viral Infection by Disrupting the ATG7-ATG8 Interaction. Plant Cell 30(7):1582-1595, 2018

12.Wang S, Xie K, Xu G, Zhou H, Guo Q, Wu J, Liao Z, Liu N, Wang Y, Liu Y*. Plant G proteins interact with ER luminal protein receptors to regulate ER retrieval. J Integr Plant Biol. 60(7):541-561, 2018

13.Haxim Y, Ismayil A, Jia Q, Wang Y, Zheng X, Chen T, Qian L, Liu N, Wang Y, Han S, Cheng J, Qi Y, Hong Y, Liu Y*, Autophagy functions as an antiviral mechanism against geminiviruses in plants. eLife 6, e23897., 2017

14.Xu G, Wang S, Han S, Xie K, Wang Y, Li J, Liu Y*, Plant Bax Inhibitor-1 interacts with ATG6 to regulate autophagy and programmed cell death. Autophagy, 13(7):1161-1175, 2017

15.Chen T, Liu D, Niu X, Wang J, Qian L, Han L, Liu N, Zhao J, Hong Y, Liu Y*, Antiviral resistance protein Tm-22 functions on the plasma membrane. Plant Physiology, 173(4): 2399-2410, 2017

16.Liu N, Xie K, Jia Q, Zhao J, Chen T, Li H, Wei X, Diao X, Hong Y, Liu Y*, Foxtail Mosaic Virus-Induced Gene Silencing in Monocot Plants, Plant Physiology, 171(3):1801-7, 2016

17.Jia Q, Liu N, Xie K, Dai Y, Han S, Zhao X, Qian L, Wang Y, Zhao J, Gorovits R, Xie D, Hong Y and Liu Y*, CLCuMuB βC1 Subverts Ubiquitination by Interacting with NbSKP1s to Enhance Geminivirus Infection in Nicotiana benthamiana, PLoS Pathogens, 12(6): e1005668, 2016

18.Zhao J*, Liu Q, Hu P, Jia Q, Liu N, Yin K, Cheng Y, Yan F, Chen J and Liu Y*, An efficient Potato virus X-based microRNA silencing in Nicotiana benthamiana, Scientific Reports 6: 20573, 2016

19.Wang Y, Zheng X, Yu B, Han S, Guo J, Tang H, Deng H, Hong Y and Liu Y*, Disruption of microtubules in plants suppresses macroautophagy and triggers starchy chloroplast autophagy, Autophagy 11(12): 2259-74, 2015

20.Han S,Wang Y, Zheng X, Jia Q, Zhao J, Bai F,Hong Y and Liu Y*, Cytoplastic glyceraldehyde-3-phosphate dehydrogenases interact with ATG3 to negatively regulate autophagy and immunity in Nicotiana benthamiana, Plant Cell  27(4):1316-31, 2015

21.Yin K, Han T, Liu G. Chen T, Wang Y, Yu A and Liu Y*, A geminivirus-based guide RNA delivery system for CRISPR/Cas9 mediated plant genome editing, Scientific Reports 5:14926, 2015

22.Sha A, Zhao J, Yin K, Tang Y, Wang Y, Wei X, Hong Y, Liu Y*, Virus-based microRNA silencing in plants, Plant Physiology, 164(1):36-47, 2014.

23.Du Y, Zhao J, Chen T, Liu Q, Zhang H, Wang Y, Hong Y, Xiao F, Zhang L, Shen Q and Liu Y*, Type I J-domain NbMIP1 proteins are required for both Tobacco mosaic virus infection and plant innate immunity, PLoS Pathogens, 9(10): e1003659, 2013.

24.Wang Y & Liu Y*,Autophagic degradation of leaf starch in plants, Autophagy, 9(8): 1247-1248, 2013

25.Wang Y, Yu B, Zhao J, Guo J, Li Y, Han S, Huang L, Du Y, Hong Y, Tang D, and Liu Y*,Autophagy Contributes to the Leaf Starch Degradation, Plant Cell, 25(4): 1383-1399, 2013

26.Zhang H, Zhao J, Liu S, Zhang D and Liu Y*, Tm-22 confers different resistance responses against Tobacco mosaic virus dependent on its expression level, Molecular Plant, 6(3): 971-974, 2013

27.Zhao J, Liu Q, Zhang H, Jia Q, Hong Y, Liu Y*, The RuBisCO small subunit is involved in the tobamovirus movement and Tm-22-mediated extreme resistance, Plant Physiology,161(1): 374-83,2013

28.Xu G, Li S, Xie K, Zhang Q, Wang Y, Tang Y, Liu D, Hong Y, He C, Liu Y*, Plant ERD2-like proteins function as ER luminal protein receptors and participate in programmed cell death during innate immunity, Plant Journal, 72(1): 57-69, 2012

29.Cai J, Xie K, Lin L, Qin B, Chen B, Meng J, Liu Y*, Cotton leaf curl Multan virus newly reported to be associated with cotton leaf curl disease in China. Plant Pathology, 59:794-795,2010

30.Tang Y, Wang F, Zhao J, Xie K, Hong Y, Liu Y*, Virus-based microRNA expression for gene functional analysis in plants, Plant Physiology 153 (2): 632-641, 2010

31.Xu G, Sui N, Tang Y, Xie K, Lai Y, Liu Y*, One-step, zero-background ligation independent cloning intron-containing hairpin RNA constructs for RNAi in plants, New Phytologist 187 (1):240–250, 2010

32.Burch-Smith T#, Schiff M#, Liu Y#, and Dinesh-Kumar SP, Efficient virus induced gene silencing in Arabidopsis thaliana, Plant Physiology, 142(1):21-27, 2006 (#co-first author)

33.Liu Y, Schiff M, Czymmek K, Talloczy Z., Levine B and Dinesh-kumar SP. Autophagy regulates programmed cell death during the plant innate immune response, Cell, 121(4), 567-577, 2005

34.Liu Y#, Burch-Smith T#, Schiff M, Feng S, Dinesh-Kumar SP. Molecular chaperone hsp90 associates with resistance protein n and its signaling proteins sgt1 and rar1 to modulate an innate immune response in plants. Journal of Biological Chemistry, 279(3): 2101-8, 2004 (#co-first author)

35.Liu Y, Schiff M, Dinesh-Kumar SP, Functional requirement of A MAPK cascades, WRKY/MYB1 transcription factors, COI1 and CTR1 in N-mediated resistance to Tobacco mosaic virus, Plant Journal, 38(5), 800-809, 2004

36.Liu Y#, Nakayama N#, Schiff M, Litt A, Irish VF and Dinesh-Kumar SP, Virus-induced silencing of a DEFICIENS ortholog in Nicotiana benthamiana, Plant Molecular Biology, 54(5), 701-711, 2004 (#co-first author)

37.Bilgin D#, Liu Y#, Schiff M, Dinesh-Kumar S. P, P58IPK, a plant ortholog of double-stranded RNA-dependent protein kinase PKR inhibitor, functions in viral pathogenesis. Developmental Cell, 4, 651-661, 2003 (# co-first author)

38.Xie Y, Liu Y*, Meng M, Chen L and Zhu Z*, Isolation and identification of a super strong plant promoter from Cotton leaf curl Multan virus, Plant Molecular Biology, 53(1), 1-14, 2003

39.Liu Y, Schiff M, Dinesh-Kumar S. P. Virus-induced gene silencing in Tomato, Plant Journal 31(6), 777-786, 2002

40.Liu Y, Schiff M, Serino G, Deng X-W and Dinesh-Kumar S. P, Role of SCF ubiqutin-ligase and the COP9 signalosome in the N-mediated resistance to tobacco mosaic virus, Plant Cell14(7), 1483-1496, 2002

41.Liu Y, Schiff M, Marathe R. and Dinesh-kumar. Tobacco Rar1, EDS1 and NPR1/NIM1 like genes are required for N-mediated resistance to tobacco mosaic virus. Plant Journal 30(4): 415-29, 2002

42.Liu Y, Robinson DJ, Harrison BD, Defective forms of cotton leaf curl virus DNA-A that have different combinations of sequence deletion, duplication, inversion and rearrangement, Journal of General Virology, 79:1501-8, 1998


●  荣誉、奖励及参加学术团体的情况:


1997年,中国科学院青年科学家奖获得者
2007年,国家杰出青年基金获得者
2007年,清华大学“百名人才引进计划” 责任教授

●  联系方式:


电话:+86-10-62794013
E-mail:yuleliu@mail.tsinghua.edu.cn