王海峰  博士

副教授

2000-2004     中国农业大学 学士    
2004-2007     清华大学 硕士    
2007-2013     加州大学戴维斯分校 博士
2013-2014      加州大学戴维斯分校 博士后
2014-2021     斯坦福大学 博士后
2021-2025 清华大学生命科学学院 助理教授
2025-至今 清华大学生命科学学院 副教授
2021-至今 清华大学生命科学联合中心 研究员

●  研究兴趣、领域：

本实验室将在哺乳动物细胞及模式生物中，开发利用CRISPR技术研究细胞发育生物学和疾病相关机理，并应用于精准医学诊断治疗。具体研究方向包括：
（1）开发CRISPR合成生物学工具从多维度研究基因组和转录组的调控机理；
（2）利用新型工具探求疾病发育过程中基因组和转录组的时空变化和基因调控的机理；
（3）精准医学：针对疾病相关的基因组或转录组异常，开发相应的诊断和靶向治疗方法。

●  代表性论文：

1. Liu M, Huang K, Zhang J, Li Q, Wang X, Gu B, Tang H, Du Z, Hu L, Qi S, Ma Y, Yu H, Xie W*, Fang X*, Wang H*. CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci, Nature Biotechnology, 2025.

2. Chen Q, Wang S, Zhang J, Xie M, Lu B, He J, Zhen Z, Li J, Zhu J, Li R, Li P, Wang H, Vakoc C, Roeder R*, Chen M*. JMJD1C forms condensate to facilitate a RUNX1-dependent gene expression program shared by multiple types of AML cells Protein & Cell, 2025 16-5, 338-364.

3. Du Z, Hu L, Zou Z, Liu M, Li Z, Lu X, Harris C, Xiang Y, Chen F, Yu G, Xu K, Kong F, Xu Q, Huang B, Liu L, Fan Q, Wang H*, Kalantry S*, Xie W*. Stepwise de novo establishment of inactive X chromosome architecture in early development, Nature Genetics, 2024 56, 2185–2198.

4. Yang L, Min Y, Liu Y, Gao B, Liu X, Huang Y, Wang H, Yang L, Liu Z, Chen L*. CRISPR-array-mediated imaging of non-repetitive and multiplex genomic loci in living cells, Nature Methods, 2024 21, 1646–1657.

5. Zhang Z, Rong X, Xie T, Li Z, Song H, Zhen S, Wang H, Wu J, Jaffrey S, Li X*. Fluorogenic CRISPR for genomic DNA imaging, Nature Communications, 2024 15, 934.

6. Li Q, Gao Y, Wang H*. CRISPR-Based Tools for Fighting Rare Diseases, Life, 2022 Nov 24; 12(12):1968.

7. Lin X, Liu Y, Liu S, Zhu X, Wu L, Zhu Y, Zhao D, Xu X, Chemparathy A, Wang H, Cao Y, Nakamura M, Noordermeer JN, La Russa M, Wong WH, Zhao K, Qi LS*. Nested epistasis enhancer networks for robust genome regulation, Science, 2022 Aug 11; Vol 377, Issue 6610, pp. 1077-1085.

8. Wang H, Han M, Qi LS, Engineering 3D genome organization, Nature Reviews Genetics, 2021 Feb;  PMID: 33558716;

9. Wang H, Nakamura M, Abbott TR, Zhao D, Luo K, Yu C, Nguyen CM, Lo A, Daley PT, La Russa M, Liu Y, Qi LS, CRISPR-mediated live imaging of genome editing and transcription. Science, 2019 Sep; Vol. 365, Issue 6459, pp. 1301-1305.

10. Wang H, Xu X, Nguyen CM, Liu Y, Gao Y, Lin X, Daley PT, Kipniss NH, La Russa M, Qi LS, CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization. Cell, 2018 Oct; 175, 1405-1417 e1414.

11. Liu Y, Yu C, Daley T, Wang F, Cao W, Lin X, Still C, Bhate S, Liu H, Zhao D, Wang H, Xie X, Ding S, Wong WH, Wernig M, Qi LS, CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming. Cell Stem Cell, 2018 Nov; 23(5):758-771.e8.

12. Kipniss N, Dingal PCD, Abbott T, Gao Y, Wang H, Dominguez A, and Labanieh L, Qi LS, Engineering Cell Sensing and Responses Using a GPCR-Coupled CRISPR-Cas System. Nature Communications, 2017 Dec; 2212.

13. Wang H, La Russa M, Qi LS, CRISPR-Cas9 in genome editing and beyond. The Annual Review of Biochemistry, 2016 Aug; Vol. 85: 227-264.

●  联系方式：

邮箱：hfwang@mail.tsinghua.edu.cn

实验室网站：http://www.wanglab-thu.org.cn/