王海峰  博士

助理教授


2000-2004     中国农业大学    学士     
2004-2007     清华大学    硕士     
2007-2013     加州大学戴维斯分校    博士
2013-2014     加州大学戴维斯分校    博士后
2014-2021     斯坦福大学    博士后
2021-现在    清华大学生命科学学院    助理教授
2021-现在    清华大学生命科学联合中心    研究员

 

●  研究兴趣、领域:


本实验室将在哺乳动物细胞及模式生物中,开发利用CRISPR技术研究细胞发育生物学和疾病相关机理,并应用于精准医学诊断治疗。具体研究方向包括:
(1)开发CRISPR合成生物学工具从多维度研究基因组和转录组的调控机理;
(2)利用新型工具探求疾病发育过程中基因组和转录组的时空变化和基因调控的机理;
(3)精准医学:针对疾病相关的基因组或转录组异常,开发相应的诊断和靶向治疗方法。

●  代表性论文:


Wang H, Han M, Qi LS, Engineering 3D genome organization, Nature Review Genetics, 2021 Feb;  PMID: 33558716;
Wang H, Nakamura M, Abbott TR, Zhao D, Luo K, Yu C, Nguyen CM, Lo A, Daley PT, La Russa M, Liu Y, Qi LS, CRISPR-mediated live imaging of genome editing and transcription. Science, 2019 Sep; Vol. 365, Issue 6459, pp. 1301-1305.
Wang H, Xu X, Nguyen CM, Liu Y, Gao Y, Lin X, Daley PT, Kipniss NH, La Russa M, Qi LS, CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization. Cell, 2018 Oct; 175, 1405-1417 e1414.
Liu Y, Yu C, Daley T, Wang F, Cao W, Lin X, Still C, Bhate S, Liu H, Zhao D, Wang H, Xie X, Ding S, Wong WH, Wernig M, Qi LS, CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming. Cell Stem Cell, 2018 Nov; 23(5):758-771.e8.
Kipniss N, Dingal PCD, Abbott T, Gao Y, Wang H, Dominguez A, and Labanieh L, Qi LS, Engineering Cell Sensing and Responses Using a GPCR-Coupled CRISPR-Cas System. Nature Communications, 2017 Dec; 2212.
Wang H, La Russa M, Qi LS, CRISPR-Cas9 in genome editing and beyond. The Annual Review of Biochemistry, 2016 Aug; Vol. 85: 227-264.
Wang H, Brust-Mascher I and Scholey JM, The microtubule cross-linker Feo controls the midzone stability, motor composition, and elongation of the anaphase B spindle in Drosophila embryos. Molecular Biology of the Cell. 2015 Apr 15; 26(8):1452-62. PMID: 25694445. Selected as the Cover paper.
Wang H, Brust-Mascher I and Scholey JM, Sliding filaments and mitotic spindle organization, Nature Cell Biology, 2014 Aug; 16(8):737-739. PMID: 25082196
Wang H, Brust-Mascher I, Civelekoglu-Scholey G and Scholey JM, Patronin mediates a switch from kinesin-13-dependent poleward flux to anaphase B spindle elongation, Journal of Cell Biology, 2013 Oct; 203(1):35-46. PMCID: PMC3798244.

●  联系方式:


邮箱:hfwang@mail.tsinghua.edu.cn