杨雪瑞 博士

副教授

1999-2003  清华大学，化学工程系，学士
2003-2009  美国密歇根州立大学，化学工程系/生物化学及分子生物学系，双学科博士
2009-2012  美国哥伦比亚大学，Irving癌症研究中心，系统生物学联合中心，博士后
2012-至今  清华大学生命科学学院，助理教授、副教授

●  研究兴趣、领域：

RNA生物信息学与癌症系统生物学：关注转录后RNA加工、翻译及非编码功能等复杂过程，提出新的数据解析理论，开发了一系列生物信息学算法与人工智能分析工具，并结合生命组学数据的深度挖掘与RNA生物学机制研究，解析生理与病理状态下遗传信息多层级传递与调控的过程与机制。研究目标是为理解肿瘤致病通路、鉴定干预靶点提供方法学支持、新的科学假说及分子机制信息。主要研究方向：

1. 多模态、跨尺度、多组学大数据的整合分析及多级调控网络与机制解析；

2. 大规模复杂生物数据的深度学习工具开发；

3. 翻译组学的系统、定量分析及翻译调控在肿瘤中的参与机制；

4. 非编码转录组的系统分析与非编码RNA生物学功能的系统鉴定。

实验室网站：labyang.com

●  代表性论文：

1. Li, F., Fang, J., Yu, Y., Hao, S., Zou, Q., Zeng, Q., and Yang, X.*, Reanalysis of ribosome profiling datasets reveals a function of rocaglamide A in perturbing the dynamics of translation elongation via eIF4A. Nat Commun, 2023. 14(1): p. 553.

2. Hu, X., Zou, Q., Yao, L., and Yang, X.*, Survey of the binding preferences of RNA-binding proteins to RNA editing events. Genome Biol, 2022. 23(1): p. 169.

3. Li, R. and Yang, X.*, De novo reconstruction of cell interaction landscapes from single-cell spatial transcriptome data with DeepLinc. Genome Biol, 2022. 23(1): p. 124.

4. Wang, Y., Zou, Q., Li, F., Zhao, W., Xu, H., Zhang, W., Deng, H., and Yang, X.*, Identification of the cross-strand chimeric RNAs generated by fusions of bi-directional transcripts. Nat Commun, 2021. 12(1): p. 4645.

5. Wang, X., Hu, X., Song, W., Xu, H., Xiao, Z., Huang, R., Bai, Q., Zhang, F., Chen, Y., Liu, Y., Fang, J., Li, X., Shen, Q., Zhao, H., and Yang, X.*, Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation. Cell Res, 2021. 31(6): p. 664-683.

6. Wang, X. and Yang, X.*, A Simple Blocking PCR-Based Method for the Synthesis of High-Copy dsDNA Tandem Repeats. Small, 2020: p. e2003671.

7. Xu, F., Du, W., Zou, Q., Wang, Y., Zhang, X., Xing, X., Li, Y., Zhang, D., Wang, H., Zhang, W., Hu, X., Liu, X., Liu, X., Zhang, S., Yu, J., Fang, J., Li, F., Zhou, Y., Yue, T., Mi, N., Deng, H., Zou, P., Chen, X., Yang, X.*, and Yu, L.*, COPII mitigates ER stress by promoting formation of ER whorls. Cell Res, 2021. 31(2): p. 141-156.

8. Zhu, M., Zou, Q., Huang, R., Li, Y., Xing, X., Fang, J., Ma, L., Li, L., Yang, X.*, and Yu, L.*, Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells. Cell Res, 2021. 31(2): p. 237-240.

9. Lin, Y., Li, F., Huang, L., Polte, C., Duan, H., Fang, J., Sun, L., Xing, X., Tian, G., Cheng, Y.*, Ignatova, Z., Yang, X.*, and Wolf, D.A.*, eIF3 Associates with 80S Ribosomes to Promote Translation Elongation, Mitochondrial Homeostasis, and Muscle Health. Mol Cell, 2020. 79(4): p. 575-587 e7.

10. Zou, Q., Xiao, Z., Huang, R., Wang, X., Wang, X., Zhao, H., and Yang, X.*, Survey of the translation shifts in hepatocellular carcinoma with ribosome profiling. Theranostics, 2019. 9(14): p. 4141-4155.

11. Liu, Y., Liu, Y., Huang, R., Song, W., Wang, J., Xiao, Z., Dong, S., Yang, Y., and Yang, X.*, Dependency of the Cancer-Specific Transcriptional Regulation Circuitry on the Promoter DNA Methylome. Cell Rep, 2019. 26(12): p. 3461-3474 e5.

12. Wu, Y., Zhao, W., Liu, Y., Tan, X., Li, X., Zou, Q., Xiao, Z., Xu, H., Wang, Y., and Yang, X.*, Function of HNRNPC in breast cancer cells by controlling the dsRNA-induced interferon response. EMBO J, 2018. 37(23).

13. Li, X., Wang, X., Song, W., Xu, H., Huang, R., Wang, Y., Zhao, W., Xiao, Z., and Yang, X.*, Oncogenic Properties of NEAT1 in Prostate Cancer Cells Depend on the CDC5L-AGRN Transcriptional Regulation Circuit. Cancer Res, 2018. 78(15): p. 4138-4149.

14. Xiao, Z., Huang, R., Xing, X., Chen, Y., Deng, H., and Yang, X.*, De novo annotation and characterization of the translatome with ribosome profiling data. Nucleic Acids Res, 2018. 46(10): p. e61.

15. Xiao, Z., Zou, Q., Liu, Y., and Yang, X.*, Genome-wide assessment of differential translations with ribosome profiling data. Nat Commun, 2016. 7: p. 11194.

●  联系方式：

电话：+86-10-62783943
E-mail：yangxuerui@tsinghua.edu.cn