颜宁 博士

教授   美国科学院外籍院士   美国艺术与科学院外籍院士


1996.09-2000.07

清华大学生物科学与技术系,学士

2000.08-2004.12

美国普林斯顿大学分子生物学系,博士

2005.01-2007.09

美国普林斯顿大学分子生物学系,博士后

2007.10-2017.05

清华大学医学院和生命科学学院,教授、博导

2017.06-2017.10

清华大学生命科学学院,兼职教授、博导

2017.06-2022.11

美国普林斯顿大学分子生物学系,雪莉·蒂尔曼终身讲席教授

2022.12-至今

清华大学生命科学学院,教授、博导


●  研究兴趣、领域:


物质的跨膜运输是维持所有物种正常生命活动的基本过程之一,跨膜运输蛋白作为位于细胞膜和细胞器膜的重要功能蛋白维持细胞正常生命过程,并完成诸如信号传导、能量转化、新陈代谢等基本生理活动,我们主要运用结构生物学和生物化学手段系统研究跨膜运输蛋白的结构与机理。

主要研究方向如下:

1. 与疾病相关重要膜转运蛋白的结构与功能的研究;

2. 电压门控离子通道的结构与工作机理;

3. 胆固醇代谢调控机理。


●  代表性论文:


1. Xia Yao, Shuai Gao#, Jixin Wang, Zhangqiang Li, Jian Huang, Yan Wang, Zhifei Wang, Jiaofeng Chen, Xiao Fan, Weipeng Wang, Xueqin Jin, Xiaojing Pan, Yong Yu, Armando Lagrutta, Nieng Yan# (2022) Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Cav channels. Cell, 185(25):4801-4810.

2. Shuai Gao, Xia Yao, Nieng Yan# (2021) Structure of human Cav2.2 channel blocked by the painkiller ziconotide. Nature, 596(7870):143-147.

3. Hongwu Qian#, Xin Zhao, Renhong Yan, Xia Yao, Shuai Gao, Xue Sun, Ximing Du, Hongyuan Yang, Catherine C L Wong, Nieng Yan# (2020) Structural basis for catalysis and substrate specificity of human ACAT1. Nature, 581(7808):333-338.

4. Huaizong Shen, Dongliang Liu, Kun Wu, Jianlin Lei, Nieng Yan# (2019) Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins. Science, 363(6433):1303-1308.

5. Xiaojing Pan, Zhangqiang Li, Qiang Zhou, Huaizong Shen, Kun Wu, Xiaoshuang Huang, Jiaofeng Chen, Juanrong Zhang, Xuechen Zhu, Jianlin Lei, Wei Xiong, Haipeng Gong, Bailong Xiao, Nieng Yan# (2018) Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1. Science, 362(6412): eaau2486.

6. Huaizong Shen, Qiang Zhou, Xiaojing Pan, Zhangqiang Li, Jianping Wu, Nieng Yan# (2017) Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution. Science, 355(6328): eaal4326.

7. Wei Peng, Huaizong Shen, Jianping Wu, Wenting Guo, Xiaojing Pan, Ruiwu Wang, S. R. Wayne Chen#, Nieng Yan# (2016) Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2. Science, 354(6310): aah5324.

8. Jianping Wu, Zhen Yan, Zhangqiang Li, Xingyang Qian, Shan Lu, Mengqiu Dong, Qiang Zhou & Nieng Yan# (2016) Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution. Nature, 537(7619): 191–196.

9. Jianping Wu, Zhen Yan, Zhangqiang Li, Chuangye Yan, Shan Lu, Mengqiu Dong, and Nieng Yan# (2015) Structure of the voltage-gated calcium channel Cav1.1 complex. Science, 350(6267): aad2395.

10. Dong Deng, Pengcheng Sun, Chuangye Yan, Meng Ke, Xin Jiang, Lei Xiong, Wenlin Ren, Kunio Hirata, Masaki Yamamoto, Shilong Fan & Nieng Yan# (2015) Molecular basis of ligand recognition and transport by glucose transporters. Nature, 526(7573): 391-396.

11. Zhen Yan, Xiao-chen Bai, Chuangye Yan, Jianping Wu, Zhangqiang Li, Tian Xie, Wei Peng, Chang-cheng Yin, Xueming Li, Sjors H. W. Scheres#, Yigong Shi# & Nieng Yan# (2015) Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution. Nature, 517(7532): 50-55.

12. Dong Deng, Chao Xu, Pengcheng Sun, Jianping Wu, Chuangye Yan, Mingxu Hu & Nieng Yan# (2014) Crystal structure of the human glucose transporter GLUT1. Nature, 510(7503): 121-125.

13. Linfeng Sun, Xin Zeng, Chuangye Yan, Xiuyun Sun, Xinqi Gong, Yu Rao, and Nieng Yan# (2012) Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature, 490(7420): 361-366.

14. Xu Zhang, Wenlin Ren, Paul DeCaen, Chuangye Yan, Xiao Tao, Lin Tang, Jingjing Wang, Kazuya Hasegawa, Takashi Kumasaka, Jianhua He, Jiawei Wang, David E. Clapham, and Nieng Yan# (2012) Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature, 486(7401): 130-134.

15. Shangyu Dang, Linfeng Sun, Feiran Lu, Jiawei Wang#, and Nieng Yan# (2010) Structure of a fucose transporter in an outward-open conformation. Nature, 467(7316), 734-738.


 

●  联系方式:


电话:+86-10-62771298(实验室)
E-mail: nyan@tsinghua.edu.cn