李丕龙 博士

副教授


1996-2000

北京大学

学士

2000-2002

香港科技大学

硕士

2002-2009

德克萨斯大学西南医学中心

博士

2009-2010

德克萨斯大学西南医学中心

博士后

2010-2015

宾夕法尼亚大学

博士后

2016-至今

清华大学生命科学学院

博导

 

●  研究兴趣、领域:


相分离现象的普适化调控机制与规律

相分离在自噬、转录调控、表观遗传等领域的生物学意义

基于相分离的技术开发与应用


●  开设的课程:


生物大分子“相变”研究进展


●  代表性论文:


1. Xu W#, Pei G#, Liu H#, Ju X, Wang J, Ding Q, Li P*. (2021) Compartmentalization-aided interaction screening reveals extensive high-order complexes within the SARS-CoV-2 proteome. Cell Rep. 36:109482.

2. Huang X#, Chen S#, Li W, Tang L, Zhang Y, Yang N, Zou Y, Zhai X, Xiao N, Liu W, Li P*, Xu C*. (2021) ROS regulated reversible protein phase separation synchronizes plant flowering. Nat Chem Bio. 17:549-557.

3. Zuo L, Zhang G, Massett M, Cheng J, Wang L, Gao Y, Li R, Huang X*, Li P*, Qi Z*. (2021) Loci-specific phase separation of FET fusion oncoproteins promotes aberrant gene transcription. Nat Commun. 12:1491.

4. Zhou M#, Li W#, Li J#, Xie L, Wu R, Wang L, Fu S, Su W, Hu J, Wang J, Li P*. (2020) Phase-separated condensate-aided enrichment of biomolecular interactions for high-throughput drug screening in test tubes. J Biol Chem. 295:11420-11434.

5. Wang L#, Hu M#, Zuo M, Zhao J, Wu D, Huang L, Wen Y, Li Y, Chen P, Bao X, Dong M, Li G*, Li P*. (2020) Rett syndrome mutations compromise MeCP2-mediated liquid-liquid phase separation of chromatin. Cell Res. 30:393-407.

6. Fang X#, Wang L#, Ishikawa R#, Li Y, Fiedler M, Liu F, Calder G, Rowan B, Weigel D, Li P*, Dean C*. (2019) Arabidopsis FLL2 promotes liquid–liquid phase separation of polyadenylation complexes. Nature. 569:265-269.

7. Gao Y#, Pei G#, Li D#, Li R, Shao Y, Zhang QC, Li P*. (2019) Multivalent m6A motifs promote phase separation of YTHDF proteins. Cell Res. 29:767-769.

8. Wang L#, Gao Y#, Zheng X#, Liu C, Dong S, Li R, Zhang G, Wei Y, Qu H, Li Y, Allis CD, Li G, Li H*, Li P*. (2019) Histone modifications regulate chromatin compartmentalization by contributing to a phase separation mechanism. Mol Cell. 76:646-659.

9. Sun D#, Wu R#, Zheng J, Li P*, Yu L*. (2018) Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation. Cell Res. 28:405-415.

10. Li P#, Banjade S#, Cheng HC#, Kim S, Chen B, Guo L, Llaguno M, Hollingsworth JV, King DS, Banani SF, Russo PS, Jiang QX, Nixon BT, Rosen MK*. (2012) Phase transitions in the assembly of multivalent signalling proteins. Nature. 483:336-340.

 

●  荣誉、奖励及参加学术团体的情况:


现任中国生物物理学会生物大分子相分离与相变分会副理事长; Molecular Cell杂志编委会成员; Biochemical Journal杂志副编辑(Associate Editor); Cell,Science等杂志的审稿人。


●  联系方式:


电话:+86-10-62794071(实验室)

电子邮件:pilongli/at/mail.tsinghua.edu.cn