王新泉 博士

教授

1990-1995, 复旦大学 学士

1995-2000, 中国科学院生物物理研究所 博士

2000-2003, 中国科学院生物物理研究所 助理研究员

2003-2008, 美国斯坦福大学 博士后

2008-2013 清华大学生命学院，准聘副教授

2013-至今 清华大学生命学院，长聘教授

 

●  研究兴趣、领域：

主要研究方向为结构生物学。利用X-射线晶体学为主要研究手段，结合其他生物化学及生物物理技术，研究细胞因子介导的宿主免疫反应和病毒侵染及免疫逃逸的结构机理。

 

●  代表性论文：

1. Chen, J., Wang, Y., & Wang, X. (2026). Structures of clinical antibodies bound to IL-33 uncover two distinct epitopes underlying differential efficacy. mAbs, 18(1), 2639673.

2. Lin, Z., Gao, T., & Wang, X. (2026). Structural basis for human DPP4 receptor recognition by MERS-like coronaviruses 2014-422 and GX2012. PLoS pathogens, 22(1), e1013792.

3. Qiao, S., & Wang, X. (2024). Structural determinants of spike infectivity in bat SARS-like coronaviruses RsSHC014 and WIV1. Journal of virology, 98(8), e0034224.

4. Lan, J., He, X., Ren, Y., Wang, Z., Zhou, H., Fan, S., Zhu, C., Liu, D., Shao, B., Liu, T. Y., Wang, Q., Zhang, L., Ge, J., Wang, T., and Wang, X. (2022). Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction. Cell research 32, 593–595.

5. Zhang, S., Qiao, S., Yu, J., Zeng, J. & Wang, X.(2021). Bat and pangolin coronavirus spike glycoprotein structures provide insights into sars-cov-2 evolution. Nature Communications, 12(1), 1607.

6. Yu, J., Qiao, S., Guo, R., & Wang, X. (2020). Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution. Nature communications, 11(1), 3070.

7. Ju, B., Zhang, Q., Ge, J., Wang, R., Sun, J., Ge, X., Yu, J., Shan, S., Zhou, B., Song, S., Tang, X., Yu, J., Lan, J., Yuan, J., Wang, H., Zhao, J., Zhang, S., Wang, Y., Shi, X., Liu, L., Zhao, J., Wang, X., Zhang, Z., Zhang, L. (2020). Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature, 584(7819), 115–119.

8. Lan, J., Ge, J., Yu, J., Shan, S., Zhou, H., Fan, S., Zhang, Q., Shi, X., Wang, Q., Zhang, L., & Wang, X. (2020). Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature, 581(7807), 215–220.

9. Zhou, H., Chen, Y., Zhang, S., Niu, P., Qin, K., Jia, W., Huang, B., Zhang, S., Lan, J., Zhang, L., Tan, W., & Wang, X. (2019). Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein. Nature communications, 10(1), 3068.

10. Ge, J., Remesh, S. G., Hammel, M., Pan, S., Mahan, A. D., Wang, S., & Wang, X. (2019). Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. Structure (London, England : 1993), 27(8), 1296–1307.e5.

11. Song, W., Gui, M., Wang, X., & Xiang, Y. (2018). Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2. PLoS pathogens, 14(8), e1007236.

12. Gui, M., Song, W., Zhou, H., Xu, J., Chen, S., Xiang, Y., & Wang, X. (2017). Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding. Cell research, 27(1), 119–129.

13. Wang, N., Shi, X., Jiang, L., Zhang, S., Wang, D., Tong, P., Guo, D., Fu, L., Cui, Y., Liu, X., Arledge, K. C., Chen, Y. H., Zhang, L., & Wang, X. (2013). Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4. Cell research, 23(8), 986–993.

14. Liu, X., Hammel, M., He, Y., Tainer, J. A., Jeng, U. S., Zhang, L., Wang, S., & Wang, X. (2013). Structural insights into the interaction of IL-33 with its receptors. Proceedings of the National Academy of Sciences of the United States of America, 110(37), 14918–14923.

15. Wang, D., Zhang, S., Li, L., Liu, X., Mei, K., & Wang, X. (2010). Structural insights into the assembly and activation of IL-1β with its receptors. Nature immunology, 11(10), 905–911.

 

●  联系方式：

             

E-mail: xinquanwang@mail.tsinghua.edu.cn