刘万里 博士

教授

1997 – 2001  中国农业大学生物学院  学士

2001 – 2005 清华大学生物科学与技术系  博士

2005 – 2007 美国加州大学旧金山分校(UCSF)微生物与免疫学系  博士后

2007 – 2011  美国国立卫生研究院(NIH)过敏与传染病研究所(NIAID)  博士后

2011.12 –   清华大学生命科学学院  副教授、教授

 

●  研究兴趣、领域：

聚焦淋巴细胞基础免疫学，探索B细胞抗原受体介导的免疫活化和抗体应答的分子机制，并分析此过程调控紊乱与相关疾病发生发展的关系。正在开展的工作包括：（1）B淋巴细胞免疫活化的分子机制及调控机制的研究；（2）B淋巴细胞异常活化导致的抗体应答缺陷，自身免疫疾病以及淋巴癌和白血病的研究；（3）抗体记忆产生储存和提取的分子机制及其干预策略；（4）B淋巴细胞感受机械力的生物学基础及其在抗体应答中的应用；（5）病原微生物作用于B淋巴细胞活化途径的免疫逃逸新机制探索；（6）构建基于上述知识的新型疫苗和新型药物等。

●  代表性论文：

[1] Yu Wang^#, Shaocun Zhang^{#, *}, Na Kang, Lihui Dong, Haochen Ni, Sichen Liu, Siankang Chong, Zhenglin Ji, Zhengpeng Wan, Xiangjun Chen, Fei Wang, Yun Lu, Baidong Hou, Pei Tong, Hai Qi, Meng Xu*, Wanli Liu*. Progressive polyadenylation and m6A modification of Ighg1 mRNA maintain IgG1 antibody homeostasis in antibody-secreting cells. Immunity, 2024, 57:2547-2564.

[2] Wenbo Sun^#, Tingyu Yang^#, Fengming Sun^#, Panhong Liu^#, Ji Gao^#, Xianmei Lan^#, Wei Xu ^#, Yuhong Pang, Tong Li, Cuifeng Li, Qingtai Liang, Haoze Chen, Xiaohang Liu, Wenting Tan, Huanhuan Zhu, Fang Wang, Fanjun Cheng, Weiwei Zhai, Han-Na Kim, Jingren Zhang, Linqi Zhang, Lu Lu*, Qiaoran Xi*, Guohong Deng*, Yanyi Huang*, Xin Jin*, Xiangjun Chen*, Wanli Liu*. An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms. Nature Immunology. 2024, 25:1809-1819.

[3] Cuifeng Li^#, Meng Zhao^#, Xiaohang Liu^#, Yuxin Li^#, Bihua Xu^#, Lina Zhou^#, Xiaolin Sun^#, Wenbo Sun, Na Kang, Zhenglin Ji, Tong Li, Haoran An, Fei Wang, Chuan Wu, Jing-Ying Ye, Jing-Ren Zhang*, Qingwen Wang*, Xiaodong Zhao*, Zhanguo Li*, Wanli Liu*. Ion channel TRPV2 is critical in enhancing B cell activation and function. J Exp Med. 2024, doi: 10.1084/jem.20221042.

[4] Bing Yang^#, Zhen Zhang^#, Xiangjun Chen^#, Xu-Yan Wang, Shishang Qin, Liaoqi Du, Changjiang Yang, Liyu Zhu, Wenbo Sun, Yongjie Zhu, Qinwen Zheng, Shidong Zhao, Quan Wang, Long Zhao, Yilin Lin, Jinghe Huang, Fan Wu, Lu Lu, Fei Wang, Wenjie Zheng, Xiao-Hua Zhou, Xiaozhen Zhao, Ziye Wang, Sun Xiao-Lin, Yingjiang Ye, Shan Wang, Zhanguo Li, Hai Qi, Zemin Zhang, Dong-Ming Kuang, Lei Zhang, Zhanlong Shen*, Wanli Liu*. An Asian-specific variant in human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment. J Clin Invest. 2022, e153454. doi: 10.1172/JCI153454.

[5] Xingwang Zhao^#, Hengyi Xie^#, Meng Zhao^#, Asma Ahsan, Xinxin Li, Fei Wang, Junyang Yi, Zhiyong Yang, Chuan Wu, Indu Raman, Quan-Zhen Li*, Tae Jin Kim*, Wanli Liu*. Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function. Science Advances. 2019, 5, eaaw0315, DOI: 10.1126/sciadv.aaw0315

[6] Chenguang Xu^#, Yan Fang^#, Zhiyong Yang, Yukai Jing, Yonghui Zhang, Chaohong Liu*, Wanli Liu*. MARCKS regulates tonic and chronic active B cell receptor signaling. Leukemia. 2019, 33:710-729.

[7] Xiangjun Chen, Xiaolin Sun^#, Wei Yang^#, Bing Yang^#, Xiaozhen Zhao, Shuting Chen1, Lili He, Hui Chen, Changmei Yang, Le Xiao, Zai Chang, Jianping Guo, Jing He, Fuping Zhang, Fang Zheng, Zhibin Hu, Zhiyong Yang, Jizhong Lou, Wenjie Zheng, Hai Qi, Chenqi Xu, Hong Zhang, Hongying Shan, Xu-jie Zhou, Qingwen Wang, Yi Shi, Luhua Lai, Zhanguo Li *, Wanli Liu*. An autoimmune disease variant of IgG1 modulates B-cell activation and differentiation. Science. 2018, 362:700-705.

[8] Yun Xia^#, Yonghua Xie^#, Zhengsen Yu^#, Hongying Xiao, Guimei Jiang, Xiaoying Zhou, Yunyun Yang, Xin Li, Meng Zhao, Liping Li, Mingke Zheng, Shuai Han, Zhaoyun Zong, Xianbin Meng, Haiteng Deng, Huahu Ye, Yunzhi Fa, Haitao Wu, Eric Oldfield, Xiaoyu Hu, Wanli Liu*, Yan Shi*, Yonghui Zhang*. The mevalonate pathway is a druggable target for vaccine adjuvant discovery. Cell. 2018, 175:1059-1073. 

[9] Zhengpeng Wan, Chenguang Xu^#, Xiangjun Chen^#, Hengyi Xie^#, Zongyu Li^#, Jing Wang^#, Xingyu Ji, Haodong Chen, Qinghua Ji, Samina Shaheen, Yang Xu, Fei Wang, Zhuo Tang, Ji-Shen Zheng, Wei Chen, Jizhong Lou, Wanli Liu*. PI(4,5)P2 determines the threshold of mechanical force-induced B cell activation. J Cell Biol. 2018, 217:2565-2582.

[10] Yonghui Sun^#, Xingwang Zhao^#, Ning Ding^#, Hongying Gao^#, Yue Wu, Yiqing Yang, Meng Zhao, Jinseok Hwang, Yuqin Song, Wanli Liu*, Yu Rao*. PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies. Cell Research. 2018, 28:779-781.

[11] Jing Wang, Liling Xu, Samina Shaheen, Sichen Liu, Wenjie Zheng, Xiaolin Sun, Zhanguo Li, Wanli Liu*. Growth of B cell receptor microclusters is regulated by PIP2 and PIP3 equilibrium and Dock2 recruitment and activation. Cell Reports. 2017, 21:2541-2557.

[12] Chenguang Xu, Hengyi Xie, Xingdong Guo, Haipeng Gong, Lei Liu, Hai Qi, Chenqi Xu, Wanli Liu*. A PIP2-derived amplification loop fuels the sustained initiation of B cell activation. Science Immunology. 2017, 2. pii: eaan0787. doi: 10.1126/sciimmunol.aan0787.

[13] Jing Wang^#, Shan Tang^#, Zhengpeng Wan, Yiren Gao, Yiyun Cao, Junyang Yi, Yanyan Si, Haowen Zhang, Lei Liu* and Wanli Liu*. Utilization of a photoactivatable antigen system to examine B cell probing termination and the B cell receptor sorting mechanisms during B cell activation. PNAS. 2016, 113:558-567.

[14] Liling Xu^#, Mengdie Xia^#, Jun Guo^#, Xiaolin Sun^#, Hua Li, Chenguang Xu, Xiaomei Gu, Haowen Zhang, Junyang Yi, Yan Fang, Hengyi Xie, Jing Wang, Zhixun Shen, Boxin Xue, Yujie Sun, Tobias Meckel, Ying-Hua Chen, Zhibin Hu, Zhanguo Li*, Chenqi Xu*, Haipeng Gong*, Wanli Liu*. Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232. J Exp Med. 2016, 213:2707-2727.

[15] Xiangjun Chen^#, Weiling Pan^#, Yinqiang Sui, Hua Li, Xiaoshan Shi, Xingdong Guo, Hai Qi, Chenqi Xu* and Wanli Liu*. Acidic phospholipids govern the enhanced activation of IgG-B cell receptor. Nature Communications. 2015, 6:8552.doi: 10.1038/ncomms9552.

●  荣誉、奖励：

中国青年科技奖、中华医学科技奖、华夏医学科技奖、药明康德生命化学杰出成就奖、谈家桢生命科学奖

●  联系方式：

地址：

Medical Science Bldg, B216

Tsinghua University, Beijing, China, 100084

Tel: +86-10-62783617

电子邮箱：

LiuLab<********>tsinghua.edu.cn (Please replace<********>with@)

或者

LiuWanli_TsinghuaU<********>126.com (Please replace<********>with@)

所有发表的论文，及其更新，请见：

https://pubmed.ncbi.nlm.nih.gov/?term=%28Liu%2C+Wanli%5BAuthor%5D+AND+Tsinghua%5BAffiliation%5D%29+OR+%28Liu%2C+Wanli%5BAuthor%5D+AND+Pierce%2C+Susan+%5BAuthor%5D+AND+Rockville%5BAffiliation%5D%29&sort=date

或者

https://orcid.org/0000-0003-0395-2800

https://www.researchgate.net/profile/Wanli_Liu3

https://loop.frontiersin.org/people/99619/overview

http://www.cls.edu.cn/info/1263/1131.htm

实验室网页：

https://www.labxing.com/wanli-liu-lab