罗永章 博士

教授

1981-1985 兰州大学化学系物理化学专业，学士                            

1989-1993 加州大学伯克利分校分子与细胞生物学系生物化学专业，博士      

1993-1994 哈佛大学医学院生物化学与分子药理学系，博士后

1994-1998 斯坦福大学医学院生物化学系，博士后    

现任清华大学生命科学学院教授、蛋白质技术国家工程研究中心主任

 

●  研究兴趣、领域：

本实验室依托清华大学生命科学学院与蛋白质技术国家工程研究中心，拥有从基础科学发现到高品质重组蛋白药物转化的全链条科研平台。我们致力于通过解析生命进化中的最基本逻辑，解决重大疾病防治中的瓶颈问题。

研究方向主要包括以下几个方面：

1. 衰老与抗衰老机制研究

从全新视角探讨生命演化中维持健康寿命的核心通路与系统性干预手段；

2. 神经退行性疾病机制研究

聚焦阿尔茨海默病 (AD)、帕金森病 (PD) 的致病机制研究及临床试验；

3. 代谢相关性疾病机制研究

从全局视角探讨2 型糖尿病、肥胖与脂代谢（含实验室首次发现的白蛋白体 "Albumosome"）、肌肉萎缩与修复、骨质疏松、类风湿关节炎的致病机制及临床转化；

4. 心血管病机制研究

核心方向：心肌肥大、心脏纤维化、房颤的致病机制及临床转化探索。

 

●  代表性论文：

1. Ma B, Ju A, Zhang S, An Q, Xu S, Liu J, Yu L, Fu Y & Luo Y*. Albumosomes formed by pre-folding albumin in cytoplasm of hepatocytes maintain mitochondrial homeostasis and inhibit nonalcoholic fatty liver disease.

Signal Transduct Target Ther. 2023;8(1):229.doi: 10.1038/s41392-023-01437-0.

2. Liu, H., Ju, A., Dong, X. et al. Young and undamaged recombinant albumin alleviates T2DM by improving hepatic glycolysis through EGFR and protecting islet β cells in mice. J Transl Med 21, 89 (2023). https://doi.org/10.1186/s12967-023-03957-3

3. Tang J, Ju A, Li B, et al. Young and Undamaged rMSA Improves the Healthspan and Lifespan of Mice. Biomolecules. 2021;11(8):1191. doi:10.3390/biom11081191

4. Liu W, Li J, Zhang P, et al. A novel pan-cancer biomarker plasma heat shock protein 90alpha and its diagnosis determinants in clinic. Cancer Sci. 2019;110(9):2941-2959. doi:10.1111/cas.14143

5. Fu Y, Xu X, Huang D, et al. Plasma Heat Shock Protein 90alpha as a Biomarker for the Diagnosis of Liver Cancer: An Official, Large-scale, and Multicenter Clinical Trial. EBioMedicine. 2017;24:56-63. doi:10.1016/j.ebiom.2017.09.007

6. Wang H, Chen Y, Lu XA, Liu G, Fu Y, Luo Y. Endostatin Prevents Dietary-Induced Obesity by Inhibiting Adipogenesis and Angiogenesis. Diabetes. 2015;64(7):2442-2456. doi:10.2337/db14-0528

7. Wang X, Song X, Zhuo W, et al. The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy. Proc Natl Acad Sci U S A. 2009;106(50):21288-21293. doi:10.1073/pnas.0908151106

8. Huang Y, Song N, Ding Y, et al. Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis. Cancer Res. 2009;69(19):7529-7537. doi:10.1158/0008-5472.CAN-08-4382. “This landmark study demonstrated that ANGPT2-, MMP3- and MMP10-dependent pulmonary vascular destabilization is an early event occurring during the pre-metastatic phase, which promotes the extravasation of tumour cells and facilitates lung metastasis.” Cited and commented by Peinado, H., Zhang, H., Matei, I. et al. Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer 17, 302–317 (2017). https://doi.org/10.1038/nrc.2017.6

9. Shi H, Huang Y, Zhou H, et al. Nucleolin is a receptor that mediates antiangiogenic and antitumor activity of endostatin. Blood. (Featured in Cover) 2007;110(8):2899-2906. doi:10.1182/blood-2007-01-064428 Comment on Shi et al, page 2899, by Judah Folkman (2007). “Endostatin finds a new partner: nucleolin” Blood. 110, 2786-2787

 

●  联系方式：

电话：+86-10-62795106

传真：+86-10-62794691

E-mail: protein@tsinghua.edu.cn