罗永章 博士

教授


1981-1985 兰州大学化学系物理化学专业                                      学士                             

1989-1993 美国加州大学伯克利分校分子与细胞生物学系生物化学专业      博士      

1993-1994 美国哈佛大学医学院生物化学与分子药物学系                  博士后      

1994-1998 美国斯坦福大学医学院生物化学系                               博士后     

现任清华大学教授

 

●  研究兴趣、领域:


课题组基于国家一类重组蛋白质候选药物,从全新角度探索疾病的分子机理并寻找潜在的治疗手段,研究兴趣如下:

    1) 2型糖尿病、肥胖等代谢疾病

    2) 阿尔茨海默症、帕金森症等退行性疾病

 

●  代表性论文:


1. Tang J, Ju A, Li B, et al. Young and Undamaged rMSA Improves the Healthspan and Lifespan of Mice. Biomolecules. 2021;11(8):1191. doi:10.3390/biom11081191

2. Zhang S, Wang C, Ma B, et al. Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion. Cell Rep. 2020;32(1):107879. doi:10.1016/j.celrep.2020.107879

3. Liu W, Li J, Zhang P, et al. A novel pan-cancer biomarker plasma heat shock protein 90alpha and its diagnosis determinants in clinic. Cancer Sci. 2019;110(9):2941-2959. doi:10.1111/cas.14143

4. Fu Y, Xu X, Huang D, et al. Plasma Heat Shock Protein 90alpha as a Biomarker for the Diagnosis of Liver Cancer: An Official, Large-scale, and Multicenter Clinical Trial. EBioMedicine. 2017;24:56-63. doi:10.1016/j.ebiom.2017.09.007

5. Liu G, Chen Y, Qi F, et al. Specific chemotherapeutic agents induce metastatic behaviour through stromal- and tumour-derived cytokine and angiogenic factor signalling. J Pathol. 2015;237(2):190-202. doi:10.1002/path.4564

6. Wang H, Chen Y, Lu XA, Liu G, Fu Y, Luo Y. Endostatin Prevents Dietary-Induced Obesity by Inhibiting Adipogenesis and Angiogenesis. Diabetes. 2015;64(7):2442-2456. doi:10.2337/db14-0528

7. Chen Y, Wang S, Lu X, Zhang H, Fu Y, Luo Y. Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways. Blood. 2011;117(23):6392-6403. doi:10.1182/blood-2010-12-322867

8. Fu Y, Luo Y. The N-terminal integrity is critical for the stability and biological functions of endostatin. Biochemistry. 2010;49(30):6420-6429. doi:10.1021/bi100489x

9. Wang X, Song X, Zhuo W, et al. The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy. Proc Natl Acad Sci U S A. 2009;106(50):21288-21293. doi:10.1073/pnas.0908151106

10. Huang Y, Song N, Ding Y, et al. Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis. Cancer Res. 2009;69(19):7529-7537. doi:10.1158/0008-5472.CAN-08-4382. “This landmark study demonstrated that ANGPT2-, MMP3- and MMP10-dependent pulmonary vascular destabilization is an early event occurring during the pre-metastatic phase, which promotes the extravasation of tumour cells and facilitates lung metastasis.” Cited and commented by Peinado, H., Zhang, H., Matei, I. et al. Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer 17, 302–317 (2017). https://doi.org/10.1038/nrc.2017.6

11. Shi H, Huang Y, Zhou H, et al. Nucleolin is a receptor that mediates antiangiogenic and antitumor activity of endostatin. Blood. (Featured in Cover) 2007;110(8):2899-2906. doi:10.1182/blood-2007-01-064428 Comment on Shi et al, page 2899, by Judah Folkman (2007). “Endostatin finds a new partner: nucleolin” Blood. 110, 2786-2787

12. Huang Y, Shi H, Zhou H, Song X, Yuan S, Luo Y. The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin. Blood. 2006;107(9):3564-3571. doi:10.1182/blood-2005-07-2961

 

●  联系方式:


电话:+86-10-62795106

传真:+86-10-62794691

E-mail: protein@tsinghua.edu.cn