徐成冉 博士
教授
1995 - 1999 , 复旦大学，遗传学专业，理学学士
2000 - 2005 , 北京大学，植物学专业，理学博士
2005 - 2008 , 美国 Scripps 研究所，Research Associate
2008 - 2009 , 美国 Fox Chase 癌症中心，Postdoctoral Associate
2009 - 2013 , 美国宾夕法尼亚大学医学院，Research Associate/Senior Investigator
2013 - 2020 , 北京大学生命科学学院，研究员
2021 - 2026 , 北京大学基础医学院，研究员
2013 - 2026 , 北大-清华生命科学联合中心，研究员
2026 - 至今 , 清华大学生命科学学院，教授
2026 - 至今 , 清华-北大生命科学联合中心，研究员
● 研究兴趣、领域：
干细胞生物学与再生医学：胚胎干细胞定向分化及组织器官再生；
发育生物学：哺乳动物内胚层来源器官（肝脏、胰腺等）的发育机制；
系统生物学：细胞信号与表观遗传机制对发育和再生过程中基因调控网络的协同调控。
● 代表性论文：
（# Co-first author; * Corresponding author）
1. Li Yang*, Yu-Heng Zhou, Junya Hayase, Lei Wang, Weiguang Zhang, Erfei Bi*, Cheng-Ran Xu*. PAR3-mediated coordination of hepatocyte proliferation, maturation, and architecture in liver development and regeneration. Nature Communications, doi: 10.1038/s41467-026-74476-0 (2026).
2. Xin-Xin Yu#, Xin Wang#, Liu Yang, Mao-Yang He, Xi Wang, Yi-Ning Wang, Ke-Ran Li, Cheng-Ran Xu*. Reconstructing human pancreatic gene networks enhances stem cell-derived β cell induction. Developmental Cell, 61(2): 276-291 (2026).
3. Li Yang#, Yu Zhang#, Xin-Xin Yu#, Yu-Heng Zhou#, Shuang He, Liu Yang, Tong-Yun Mao, Jun-Ge Yang, Ying Wu, Qi-Qi Zheng, Xun-Kai Li, Hou-Zao Chen, Cheng-Ran Xu*, Hepatocyte metabolic adaptations during pregnancy and lactation. Cell, 188(23):6572-6590 (2025).
4. Ke-Ran Li#, Pei-Long Yu#, Qi-Qi Zheng#, Xin Wang, Xuan Fang, Lin-Chen Li and Cheng-Ran Xu*, Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution. Cell, 188(3):796-813 (2025).
5. Liu Yang#, Xin-Xin Yu#, Xin Wang, Chen-Tao Jin, Cheng-Ran Xu*, The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation. Science Advances, 22(13): eadt4770 (2025).
6. Yu Zhang#, Shuang He#, Xi Wang, Xin Wang, Mao-Yang He, Xin-Xin Yu, Cheng-Ran Xu*, ACSS2 mediates an epigenetic pathway to regulate β-cell adaptation during gestation in mice. Nature Communications, DOI: 10.1038/s41467-025-58322-3 (2025).
7. Xin-Xin Yu, Peng Peng, Chen-Tao Jin, Mao-Yang He, Shuang He, Liu Yang, Xi Wang, Jia-Xi Zheng, Jie Gao, Cheng-Ran Xu*, Comprehensive characterization of bihormonal cells and endocrine cell lineages in mammalian pancreatic islets. Advanced Science, doi: 10.1002/advs.202416326 (2025).
8. Li Yang#, Xin Wang#, Jia-Xi Zheng, Zi-Ran Xu, Lin-Chen Li, Yu-Long Xiong, Bi-Chen Zhou, Jie Gao, Cheng-Ran Xu*, Determination of key events in mouse hepatocyte maturation at the single-cell level. Developmental Cell, 58(19):1996-2010 (2023).
9. Li Yang#, Xin Wang#, Xin-Xin Yu, Lu Yang, Jing Yang, Cheng-Ran Xu*, The default and directed pathways of hepatoblast differentiation involve distinct epigenomic mechanisms. Developmental Cell, 58(18): 1688-1700 (2023).
10. Xin-Xin Yu#, Wei-Lin Qiu#, Liu Yang#, Yan-Chun Wang#, Mao-Yang He, Dan Wang, Yu Zhang, Lin-Chen Li, Jing Zhang, and Yi Wang, Cheng-Ran Xu*, Sequential progenitor states mark the generation of pancreatic endocrine lineages in mice and humans. Cell Research, 31(8): 886-903 (2021).
11. Lin-Chen Li#, Xin Wang#, Zi-Ran Xu#, Yan-Chun Wang#, Ye Feng, Liu Yang, Wei-Lin Qiu, Li Yang, Xin-Xin Yu, Jun Gu, Cheng-Ran Xu*, Single-cell patterning and axis characterization in the murine and human definitive endoderm. Cell Research, 31(3): 326-344 (2021).
12. Xin Wang#, Li Yang#, Yan-Chun Wang#, Zi-Ran Xu, Ye Feng, Jing Zhang, Yi Wang, Cheng-Ran Xu*, Comparative analysis of cell lineage differentiation during hepatogenesis in humans and mice at the single-cell transcriptome level. Cell Research, 30(12):1109-1126 (2020).
13. Xin-Xin Yu#, Wei-Lin Qiu#, Liu Yang, Yu Zhang, Mao-Yang He, Lin-Chen Li, Cheng-Ran Xu*, Defining multistep cell fate decision pathways during pancreatic development at single-cell resolution. The EMBO Journal, 15;38(8):e100164 (2019).
14. Li Yang#, Wei-Hua Wang#, Wei-Lin Qiu#, Zhen Guo, Erfei Bi, Cheng-Ran Xu*, A single-cell transcriptomic analysis reveals precise pathways and regulatory mechanisms underlying hepatoblast differentiation. Hepatology, 66(5):1387-1401 (2017).
15. Wei-Lin Qiu#, Yu-Wei Zhang#, Ye Feng#, Lin-Chen Li, Liu Yang, Cheng-Ran Xu*, Deciphering pancreatic islet β-cell and α-cell maturation pathways and characteristic features at the single-cell level. Cell Metabolism, 25:1194-1205 (2017).
● 联系方式：
E-mail: crxu@tsinghua.edu.cn
