郗乔然 博士

副教授

1989-1993年，南京大学生物化学系　　　　　学士

1998-2004年，美国纽约大学医学院　　　　　博士

2004-2005年，美国纽约大学医学院　　　　　博士后

2006-2013年，美国斯隆凯特琳癌症研究中心　博士后

2013年至今，  清华大学生命科学学院　　　　助理教授、副教授

●  研究兴趣、领域：

本课题组的学术研究主要是运用细胞生物学，生物化学，分子生物学，基因组学等方法研究TGF-beta信号传导在胚胎干细胞的自我更新和胚胎发育及癌症发生过程中的作用机制；针对性研究TGF-beta及相关信号传导通路如何通过与表观遗传图谱相互作用，在时间和空间上紧密调控基因表达从而调控胚胎发育及癌症发生。本课题组的研究对象是小鼠胚胎干细胞和弥漫内生型脑干胶质瘤（DIPG）。

●  开设的课程：

分子生物学（英）（H）、生命科学交叉创新挑战性问题研讨课（X-idea）、科研训练（H）

●  代表性论文：

1. Wang D, Yan K, Yu H, Li H, Zhou W, Hong Y, Guo S, Wang Y, Xu Chen, Pan C, Tang Y, Liu N, Wu W, Zhang L*, Xi Q*. (2024) Fimepinostat impairs NF­κB and PI3K/AKT signaling and enhances gemcitabine efficacy in H3K27M-mutated diffuse intrinsic pontine glioma. Cancer Research. 84(4), p. 598-615.

2. Zhou W#, Yan K# & Xi Q*. (2023) BMP signaling in cancer stemness and differentiation. Cell Regeneration. 12:37. https://doi.org/10.1186/s13619-023-00181-8 (Review)

3. Sun H#, Chen Y#, Yan K, Shao Y, Zhang Q, Lin Y*, Xi Q*. (2023) Recruitment of TRIM33 to cell‐context specific PML nuclear bodies regulates nodal signaling in mESCs. The EMBO Journal. 42(3): e112058.

4. Kong X, Yan K, Deng P, Fu H, Sun H, Huang W, Jiang S, Dai J, Zhang Q, Liu J and Xi Q*. (2022) LncRNA-Smad7 mediates cross-talk between Nodal/TGF-β and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells. Nucleic Acids Research. 5(18): 10526-10543.

5. Sun Y#, Yan K#, Wang Y#, Xu C#, Wang D, Zhou W, Guo S, Han Y, Tang L, Shao Y, Shan S, Zhang Q, Tang Y, Zhang L*, Xi Q*. (2022) Context-dependent tumor suppressive BMP signaling in Diffuse Intrinsic Pontine Glioma regulates stemness through epigenetic regulation of CXXC5. Nature Cancer. 3(9): 1105-1123. (featured article with an editor’s digest)

6. Liang T#, Bai J#, Zhou W, Lin H, Ma S, Zhu X, Tao Q, Xi Q*. (2022) HMCES modulates the transcriptional regulation of nodal/activin and BMP signaling in mESCs. Cell Reports. 40(2):111038.

7. Fu H, Wang T, Kong X, Yan K, Yang Y, Cao J, Yuan Y, Wang N, Kee K, Lu Z, Xi Q*. (2022) A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells. Nature Communications. 13(1): 3984.

8. Zuo F#, Jiang J#, Fu H#, Yan K, Liefke R, Zhang J, Hong Y, Chang Z, Liu N, Wang Z*, Xi Q*. (2022) A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells. Cell Stem Cell. 29(6), 948-961.

9. Luo M, Bai J#, Liu B#, Yan P#, Zuo F, Sun H, Sun Y, Xu X, Song Z, Yang Y, Massagué J, Lan X, Lu Z, Chen YG, Deng H, Xie W, and Xi Q*. (2019) H3K18ac primes mesendodermal differentiation upon nodal signaling. Stem Cell Reports.13(4): 642-656.

10. Sun Y#, Sun Y#, Yan K, Li Z, Xu C, Geng Y, Pan C, Chen X, Zhang l*, Xi Q*. (2019) Potent anti-tumor efficacy of palbociclib in H3.3K27M-mutant diffuse intrinsic pontine glioma. EBioMedicine. 43:171-179. ( featured article with a preview commentary)

11. Tian W#, Yan P#, Xu N, Chakravorty A, Liefke R*, Xi Q* and Wang Z*. (2019) The HRP3 PWWP domain recognizes the minor groove of double-stranded DNA and recruits HRP3 to chromatin. Nucleic Acids Research. 47(10): 5436-5448.

12. Bai J, Xi Q*. (2018) Crosstalk between TGF-β signaling and epigenome. Acta Biochimica Biophys Sin. 50(1): 60-67. (Review)

13. Xia X, Zuo F, Luo M, Sun Y, Bai J, Xi Q*. (2017) Role of TRIM33 in Wnt signaling during mesendoderm differentiation. Sci China Life Sci. 60(10): 1142-1149.

14. Massagué J, and Xi Q. (2012) TGF-β control of stem cell differentiation genes. FEBS Letters. 586: 1953-8. (Review)

15. Xi Q, Wang Z, Zaromytidou AI, Zhang XH, Chow-Tsang L, Liu JX, Kim H, Manova-Todorova K, Kaartinen V, Studer L, Mark W, Patel DJ, and Massagué J*. (2011) A poised chromatin platform for TGFβ access to master regulators. Cell. 147: 1511-24.

 

●  联系方式：

电话：+86-10-62789636（实验室）

公众号：

E-mail：xiqiaoran@tsinghua.edu.cn

通讯地址：清华大学郑裕彤医学楼