时松海 博士
教授
1991-1996／清华大学生物科学与技术系／学士
1996-2001／美国冷泉港实验室&纽约州立大学石溪分校／遗传学博士
2001-2006／美国加州大学旧金山分校&霍华德-休斯医学研究所／博士后
2006-2019／美国纪念斯隆-凯特琳癌症中心／助理研究员／副研究员／研究员
2006-2019／美国康奈尔医学院／助理教授／副教授／教授
2019-至今／清华大学生命科学学院 & 清华大学-IDG/麦戈文脑科学研究院／教授 & 院长
● 研究兴趣、领域：
神经系统是如何发育组装的，以及如何调控动物的行为和认知一直是神经科学的研究热点和终极目标之一。我们运用神经生物学（如电生理和成像）、遗传学、分子、细胞和发育生物学等方法研究哺乳动物大脑的组装和运行机制，集中于活体神经干细胞的调控、神经细胞的产生分化迁移、神经环路的精准组装和运行、以及动物行为的神经基础；同时致力于与神经发育和功能相关的重大疾病如小脑症和自闭症的致病机制研究。
● 代表性论文：
1. Dong, X., Zhang, Q., Yu, X., Wang, D., Ma, J., Ma, J., & Shi, S. H*. (2022). Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex. Nature neuroscience, 25(7), 865–875.
2. Lv, X., Li, S., Li, J., Yu, X. Y., Ge, X., Li, B., Hu, S., Lin, Y., Zhang, S., Yang, J., Zhang, X., Yan, J., Joyner, A. L., Shi, H., Wu, Q., & Shi, S. H. (2022). Patterned cPCDH expression regulates the fine organization of the neocortex. Nature, 612(7940), 503–511.
3. Ren, S.Q., Li, Z., Lin, S., Bergami, M., and Shi, S.-H. (2019) Precise long-range microcircuit-to-microcircuit communication connects the frontal and sensory cortices in the mammalian brain. Neuron.104, 1-17. (PMID: 31371111)
4. Lv X., Ren, S.-Q., Zhang, X.-J., Shen Z., Ghosh, T., Xianyu, A., Gao, P., Li, Z., Lin, S., Yu, Y., Zhang, Q., Groszer, M., and Shi, S.-H. (2019) TBR2 coordinates neurogenesis expansion and precise microcircuit organization via Protocadherin 19 in the mammalian cortex. Nat. Commun. 10(1):3946. (PMCID: PMC6718393)
5. Sultan, K.T., Liu, W.A., Li, Z.-L., Shen, Z., Li, Z., Zhang X.-J., Dean, O., Ma, J., and Shi, S.-H. (2018) Progressive divisions of Mmultipotent neural progenitors generate late-born chandelier cells in the neocortex. Nat. Commun. 9: 4595. (PMCID: PMC6214958)
6. Liu, W.-A., Chen, S., Li, Z., Lee, C.,-H., Mirzaa, G., Dobyns, W.B., Ross, M.E., Zhang, J., and Shi, S.-H. (2018) PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia. Genes & Dev. 32: 763-780. (PMCID: PMC6049519)
7. Zhang, X.-J., Li, Z., Han, Z., Sultan, K.T., Huang, K., and Shi, S.-H. (2017) Precise inhibitory microcircuit assembly of developmentally related neocortical interneurons in clusters. Nat. Commun. 8:16091. (PMCID: PMC5511369)
8. Shi, W., Xianyu, A., Han, Z., Tang, X., Li, Z., Zhong, H., Mao, T., Huang, K., and Shi, S.-H. (2017) Ontogenetic establishment of order-specific nuclear organization in the mammalian thalamus. Nat. Neurosci. 20: 516-528 (PMCID: PMC5374008)
9. Qi, Y., Zhang, X.-J., Renier, N., Wu, Z., Atkin, T., Sun, Z., Ozair, M.Z., Tchieu, J., Zimmer, B., Fattahi, F., Ganat, Y., Azevedo, R., Zeltner, N., Brivanlou, A.H., Karayiorgou, M., Gogos, J., Tomishima, M., Tessier-Lavigne, M., Shi, S.-H., and Studer, L. (2017) Combined small-molecule inhibition accelerates the derivation of functional, early-born, cortical neurons from human pluripotent stem cells. Nat. Biotechnol. 35:154-163. (PMCID: PMC5516899)
10. Sultan, K.T.*, Han, Z.*, Zhang, X.-J.*, Xianyu, A., Li, Z., Huang, K., and Shi, S.-H. (2016) Clonally related GABAergic interneurons do not randomly disperse but frequently form local clusters in the forebrain. (* Co-first author) Neuron 92: 31-44. (PMCID: PMC5066572)
11. Tan, X., Liu, W.A., Zhang, X.-J., Shi, W., Ren, S.-Q., Li, Z., Brown, K.N., and Shi, S.-H. (2016) Vascular regulation of ventral telencephalic progenitors and neocortical interneuron production. Dev. Cell 36:624-638. (PMCID: PMC4806403)
12. He, S., Li, Z., Ge, S., Yu, Y.-C., and Shi, S.-H. (2015) Inside-out radial migration facilitates lineage-dependent microcircuit assembly in the neocortex. Neuron 86: 1159-1166. (PMCID: PMC4458701)
13. Gao, P., Postiglione Pia, M., Krieger, T.G., Hernandez, L., T., Wang, C., Han, Z., Streicher, C., Papusheva, E., Insolera, R., Chugh, K., Kodish, O., Huang, K., Simons, B.D., Luo, L., Hippenmeyer, S., and Shi, S.-H. (2014) Deterministic progenitor behavior and unitary production of neurons in the neocortex. Cell 159:775-788. (PMCID: PMC4225456)
14. Insolera, R., Bazzi, H., W. Shao, Anderson, K.V., and Shi, S.-H. (2014) Cortical neurogenesis in the absence of centrioles. Nat. Neurosci. 17:1528-1535. (PMCID: PMC4213237)
15. Insolera, R., Shao, W., Airik, R., Hildebrandt, F., and Shi, S.-H. (2014) SDCCAG8 regulates pericentriolar material recruitment and neuronal migration in the developing neocortex. Neuron 83: 805-822. (PMCID: PMC4141904)
16. Xu, H.-T., Han Z., Gao, P., He, S., Li, Z., Shi, W., Kordish, O., Shao, W., Brown, K.N., Huang, K., and Shi. S-H. (2014) Lineage-dependent structural and functional organization of the hippocampus. Cell 157: 1552-1564. (PMCID: PMC4120073)
17. Chen, S., Chen, J., Shi, H., Wei, M., Castaneda-Castellanos, D.R., Pei, X., Kriegstein, A.R., Zhang M.-J., and Shi, S.-H. (2013) Regulation of microtubule stability and organization by mammalian Par3 in specifying neuronal polarity. Dev. Cell 24: 26-40. (PMCID: PMC3375857)
18. Li, Y., Lu, H., Cheng, P.-l., Ge, S., Xu, H., Shi, S.-H., and Dan, Y. (2012) Clonally related visual cortical neurons show similar stimulus feature selectivity. Nature 486:118-21. (PMCID: PMC3375857)
19. Yu, Y.-C., He, S., Chen, S., Fu, Y., Brown, K.N., Yao, X.H., Ma, J., Gao, K.P., Sosinsky, G.E., Huang, K., and Shi, S.-H. (2012) Preferential electric coupling regulates neocortical lineage-dependent microcircuit assembly. Nature 486:113-7. (PMCID: PMC3599787)
20. Brown, K.N., Chen, S., Han, Z., Lu, C.-H., Tan, X., Ding, L., Zhang, X.-J., Cruz, A. L., Saur, D., Anderson, S.A., Huang, K., and Shi, S.-H. (2011) Clonal Production and Organization of Inhibitory Interneurons in the Neocortex. Science 334: 480-486. (PMCID: PMC3304494)
21. Wang, X., Tsai, J.-W., Imai, J.H., Lin, W.-N., Valle, R.B., and Shi, S.-H. (2009) Asymmetric centrosome inheritance maintains neural progenitors in the neocortex. Nature 461: 947-955. (PMCID: PMC2764320)
22. Bultje, R.S., Castaneda-Castellanos, D.R., Jan, L.Y., Jan, Y.N., Kriegstein, A.R., and Shi, S.-H. (2009) Mammalian Par3 regulates progenitor cell asymmetric division via Notch signaling in the developing neocortex. Neuron 63: 189-202. (PMCID: PMC2736606)
23. Yu, Y.-C., Bultje, R.S., Wang, X., and Shi, S.-H. (2009) Specific synapses develop preferentially among sister excitatory neurons in the neocortex. Nature 458: 501-504. (PMCID: PMC2727717)
24. Huang, C.S.*, Shi, S.-H.*, Ule, J., Ruggiu, M., Barker, L.A., Darnell, R.B., Jan, Y.N., and Jan, L.Y. (2005). Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition. Cell 123:105-118 (* contributed equally). (PMID: 16213216)
25. Shi, S.-H., Cheng, T., Jan, L.Y., and Jan, Y.N. (2004). The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation. Proc. Natl. Acad. Sci. USA 101:13346-13351. (PMCID: PMC516569)
26. Shi, S.-H., Cox, D.N., Wang, D., Jan, L.Y., and Jan, Y.N. (2004). Control of dendrite arborization by an Ig family member, dendrite arborization and synapse maturation 1 (Dasm1). Proc. Natl. Acad. Sci. USA 101:13341-13345. (PMID: 15340157)
27. Shi, S.-H., Jan, L.Y., and Jan, Y.-N. (2003). Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity. Cell 112:63-75. (PMID: 12526794)
28. Shi, S.-H., Hayashi, Y., Esteban, J.A., and Malinow, R. (2001). Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons. Cell 105:331-343. (PMID: 11348590)
29. Hayashi, Y. *, Shi, S.-H. *, Esteban, J.A., Piccini, A., Poncer, J.-C., and Malinow, R. (2000). Driving AMPA receptors into synapses by LTP or CaMKII: Requirement for GluR1 and PDZ domain interaction. Science 287:2262-2267 (* contributed equally). (PMID: 10731148)
30. Shi, S.-H., Hayashi, Y., Petralia, R.S., Zaman, S.H., Wenthold, R.J., Svoboda, K., and Malinow, R. (1999). Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. Science 284:1811-1816. (PMID: 10364548)
● 荣誉、奖励及参加学术团体的情况：
Breakthrough of the Year, Runner-up, Science (1999)
Amersham Biosciences and Science Prize for Young Scientists, Grand Prize (2001)
Helen Hay Whitney Foundation Fellowship (2002)
Klingenstein Award (2007)
NARSAD Young Investigator Award (2008)
McKnight Scholar Award (2010)
Blavatnik Awards for Young Scientists (2010)
The Vilcek Prize for Creative Promise in Biomedical Science, Finalist (2012)
Howard Hughes Medical Institute (HHMI) Faculty Scholar Award (2016)
北京市卓越青年科学家（2019）
● 联系方式：
电话：010-62791995
邮箱：shisonghai@mail.tsinghua.edu.cn
通讯地址：北京市清华大学生物医学馆B305
网页：http://shis-lab.life.tsinghua.edu.cn/#/home
