Guangshuo Ou, Ph.D.

Principal Investigator Recipient of The National Science Fund for Distinguished Young Scholars

1994-2001 B.S. & M.S. China Agricultural University, College of Biological Sciences

2001-2006 Ph.D.  Cell & Developmental Biology, University of California, Davis

2007-2011 Postdoctoral Research Fellow, University of California, San Francisco/HHMI

2011-2013 Professor, Institute of Biophysics, Chinese Academy of Sciences

2013-present, Principal Investigator, School of Life Sciences, Tsinghua University



Research interest

Our laboratory studies how cytoskeleton and signaling-related biomacromolecules regulate neural progenitors to migrate, divide and differentiation using Caenorhabditis elegans as the model system. We developed fluorescence time-lapse imaging techniques to visualize neuroblast development in live animals, and we have also developed C. elegansconditional knockout methods to dissect the underlying molecular mechanisms.



Selected publications

  1. Spectraplakin Induces Positive Feedback between Fusogens and the Actin Cytoskeleton to Promote Cell-Cell Fusion. Yang Y, Zhang Y, Li WJ, Jiang Y, Zhu Z, Hu H, Li W, Wu JW, Wang ZX, Dong MQ, Huang S, Ou G*. Developmental Cell. 2017 Apr 10;41(1):107-120.
  2. Feng G, Zhu Z, Li W, Chai Y, Dong M and Ou G*. Hippo Kinases Maintain Polarity during Directional Cell Migration in C. elegans. EMBO J. 2017 Feb 1;36(3):334-345.
  3. Zhu Z, Chai Y, Jiang Y, Li WJ, Hu H, Li W, Wu J, Wang Z, Huang S and Ou G*. Functional Coordination of WAVE and WASP in C. elegans Neuroblast Migration. Developmental Cell. 2016 Oct 24;39(2):224-238.
  4. Tian D, Diao M, Jiang Y, Sun L, Zhang Y, Chen Z, Huang S and Ou G*.(2015)  Anillin Regulates Neuronal Migration and Neurite Growth by Linking RhoG to the Actin Cytoskeleton. Current Biology. 2015 May 4; 25(9):1135-45.
  5. Li WJ, Yi P and Ou G*. (2015) Somatic  CRISPR/Cas9-induced  Mutations  Reveal  Roles  of  Embryonically  Essential  Dynein  Chains  in Caenorhabditis elegans Cilia. J. Cell Biol. 2015 March 16; 208 (6)
  6. Shen Z, Zhang X, Chai Y, Zhu Z, Yi P, Feng G, Li W and Ou G.* (2014)  Conditional Knockouts Generated by Engineered CRISPR-Cas9 Endonuclease Reveal the Roles of Coronin in C. elegans Neural Development. Developmental Cell. 2014 Sept 08; 30(5):625-36.
  7. Cheng Z, Yi P, Wang X, Chai Y, Feng G, Yang Y, Liang X, Zhu Z, Li W *, and Ou G.* (2013)  Conditional Targeted Genome Editing Using Somatically Expressed TALENs in C. elegans. Nature Biotechnology. 2013 Oct;31(10):934-7.
  8. Feng G, Yi P,  Yang Y, Chai Y, Tian D, Zhu Z, Liu J, Zhou F, Cheng Z, Wang X, Li W, and Ou G.* (2013) Developmental Stage-Dependent Transcriptional Regulatory Pathways Control Neuroblast Lineage Progression. Development. 2013 Aug 14.
  9. Wang X, Zhou F, Lv S, Yi P, Zhu Z, Yang Y, Feng G, Li W, and Ou G.* (2013) Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11175-80.
  10. Chai Y, Tian D, Feng G, Cheng Z, Yang Y, Li W and Ou, G.* (2012)  Apoptotic Regulators Promote Midbody Degradation in C. elegans. Journal of Cell Biology. 2012 Dec; 199(7):1047-55.
  11. Ou, G.*, Stuurman N, D'Ambrosio, M and R.D. Vale*. (2010) Polarized myosin produces unequal size daughters during asymmetric cell division. Science. 330(6004):677-80.
  12. Ou, G., Blacque, O.E., Snow, J.J., Leroux, M.R., and J.M. Scholey (2005) Functional Coordination of Intraflagellar Transport Motors. Nature.  436(7050):583-7.


Contact information

Tel: +86-10-62794766