熊巍  博士

副教授


教育经历

1999      武汉大学生命科学学院  学士

2006     中科院神经科学研究所  博士

工作经历

2006-2007     北京大学分子医学研究所 研究助理

2007-2015    美国斯克里普斯研究所 博士后

2015-2021     清华大学生命科学学院 助理教授

2021-            清华大学生命科学学院 副教授

 

●  研究兴趣、领域:


听觉感受是我们日常最重要的感觉之一,然而与其相关的分子和神经机制还有很多未知之处。本研究组关注听觉产生所用到的耳蜗毛细胞机械转导的分子细胞机制,以及神经疾病(例如自闭症)听觉感受异常的神经机制。从方法学上,我们利用携带病人突变的遗传改造小鼠为动物模型,通过分子和细胞生物学、电生理、光学成像等技术,在离体和在体层面研究我们目前重点关注的3个问题:(一)毛细胞机械转导通道的分子和门控机制;(二)听觉通路信息处理的神经机制,包括小鼠如何通过超声发声进行交流等;(三)遗传性耳聋的基因治疗。本研究组的长期目标是系统研究听觉、言语和交流相关的神经机制以及相关的疾病机理,并发展可能的生物学治疗策略和干预手段。


●  代表性论文:


1. Li, J.#, Liu, S.#, Song, C.#, Zhu, T., Zhao, Z., Sun, W., Wang, Y.*, Song, L.*, and Xiong, W.* (2022) Prestin-Mediated Frequency Selectivity Does not Cover Ultrahigh Frequencies in Mice. Neuroscience Bulletin 38, 17

2. Yan, Y.#, Tian, M.#, Li, M., Zhou, G., Chen, Q., Xu, M., Hu, Y., Luo, W., Guo, X., Zhang, C., Xie, H., Wu, Q. F., Xiong, W.*, Liu, S.*, and Guan, J. S.* (2022) ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder. Neuron 6273 (21) 01090-4.

3. Zhang, Y.#, Lin, G.#, Wang, Y.#*, Xue, N., Lin, X., Du, T.*, Xiong, W.*, and Song, L.* (2021) Prestin derived OHC surface area reduction underlies age-related rescaling of frequency place coding. Hearing Research 108406.

4. Song, C.#, Li, J.#, Liu, S., Hou, H., Zhu, T., Chen, J., Liu, L., Jia, Y., and Xiong, W. (2021) An L1 retrotransposon insertion induced deafness mouse model for studying the development and function of the cochlear stria vascularis. Proc Natl Acad Sci U S A 118 (40) e2107933118.    

5. Li, J.#, Liu, S.#, Song, C.#, Hu, Q.#, Zhao, Z.#, Deng, T., Wang, Y., Zhu, T., Zou, L., Wang, S., Chen, J., Liu, L., Hou, H., Yuan, K., Zheng, H., Liu, Z., Chen, X., Sun, W., Xiao, B., and Xiong, W. (2021) PIEZO2 mediates ultrasonic hearing via cochlear outer hair cells in mice. Proc Natl Acad Sci U S A 118 (28) e2101207118.

6. Liu, S., Wang, S., Zou, L., and Xiong, W. (2021) Mechanisms in cochlear hair cell mechano-electrical transduction for acquisition of sound frequency and intensity. Cell Mol Life Sci 78, 5083-5094 (Review).

7. Du, H.#, Zou, L.#, Ren, R., Li, N., Li, J., Wang, Y., Sun, J., Yang, J., Xiong, W.*, and Xu, Z.* (2020). Lack of PDZD7 long isoform disrupts ankle-link complex and causes hearing loss in mice. FASEB J 34, 1136-1149.

8. Wang, Y., Su, F., Wang, S., Yang, C., Tian, Y., Yuan, P., Liu, X., Xiong, W.*, and Zhang, C.* (2019) Efficient implementation of convolutional neural networks in the data processing of two-photon in vivo imaging. Bioinformatics 35, 3208-3210.

9. Liu, S.#, Wang, S.#, Zou, L.#, Li, J., Song, C., Chen, J., Hu, Q., Liu, L., Huang, P., and Xiong, W. (2019). TMC1 is an essential component of a leak channel that modulates tonotopy and excitability of auditory hair cells in mice. Elife 8, e47441.

10. Xiong, W.* and Xu, Z.* (2018) Mechanotransduction of the Hair Cell. Springer Singapore (Book, ISBN:9789811085574)

11. Hu, Q.#, Guo, L.#, Li, J., Song, C., Yu, L.*, He, D.Z.Z.*, and Xiong, W.* (2018). Deletion of Kncn Does Not Affect Kinocilium and Stereocilia Bundle Morphogenesis and Mechanotransduction in Cochlear Hair Cells. Front Mol Neurosci 11, 326.

12. Chen, J.#, Zhang, X.#, Li, J., Song, C., Jia, Y.*, and Xiong, W.* (2016). Identification of a Novel ENU-Induced Mutation in Mouse Tbx1 Linked to Human DiGeorge Syndrome. Neural Plast 2016, 5836143.

 

●  联系方式:


医学科学楼B216
清华大学
北京100084
Tel: +86-10-62792464(office) +86-10-62796344(lab)
Email: wei_xiong@tsinghua.edu.cn
Lab page: neurocomlab.org