José Carlos PASTOR-PAREJA

副教授

1999  西班牙阿利坎特大学，获生物学学士学位

2004  西班牙马德里自治大学，获分子生物学博士学位

2005-2011  美国耶鲁大学 遗传系，博士后

2011-2012  美国耶鲁大学 遗传系，副研究员

2012-   清华大学生命科学学院，PI

●  研究兴趣、领域：

我们了解生物机体的一个主要的障碍是其在组织水平上的复杂性。基膜（basement membranes，BMs）是由高度保守的细胞外基质蛋白的聚合物，它与其组分为所有动物组织都提供了必要的结构性支持。在细胞的形态发生，细胞信号，免疫反应，细胞再生和肿瘤形成的过程中，基膜与其组分都起着关键的作用。我们在最近的研究中发现，基膜的两个重要的组成成分IV型胶原蛋白（Collagen IV）和串珠素（Perlecan），发挥相反的作用力来决定细胞和器官的形状。目前本实验室正在进行的几个项目，研究的就是基底膜各组分如何分泌并组装成多聚体及其在发育、再生和癌症中的作用。

 

●  代表性论文：

1. Intrinsic and damage-induced JAK/STAT signaling regulate developmental timing by the Drosophila prothoracic gland.

Cao X, Rojas-Amado M, Pastor-Pareja JC*.

Dis Model Mech (2021) 15:dmm049160

2. ER exit sites in Drosophila display abundant ER-Golgi vesicles and pearled tubes but no megacarriers.

Yang K‡, Liu M‡, Feng Z, Rojas-Amado M, Zhou L, Ke H, Pastor-Pareja JC*.

Cell Rep (2021) 36:109707

3. Atypical laminin spots and pull-generated microtubule-actin projections mediate Drosophila wing adhesion.

Sun T, Song Y, Teng D, Chen Y, Dai J, Ma M, Zhang W, Pastor-Pareja JC*.

Cell Rep (2021) 36:109667

4. Tales of the ER-Golgi frontier: Drosophila-centric considerations on Tango1 function.

Feng Z‡, Yang K‡, Pastor-Pareja JC*.

Front Cell Dev Biol (2021) 8:619022 (Review).

5. Atypical basement membranes and basement membrane diversity: what is normal, anyway?

Pastor-Pareja JC*.

J Cell Sci (2020) 133: jcs241794 (Review).

6. Spectraplakin Shot maintains perinuclear microtubule organization in Drosophila polyploid cells.

Sun T, Song Y, Dai J, Mao D, Ma M, Ni J-Q, Liang X, Pastor-Pareja JC*.

Dev Cell (2019) 49:1-7.

7. Dissection of Nidogen function in Drosophila reveals tissue-specific mechanisms of basement membrane assembly.

Dai J, Estrada B, Jacobs S, Sanchez-Sanchez-B, Tang J, Ma M, Pastor-Pareja JC*, Martin-Bermudo MD*.

PLoS Genet (2018) 14:e1007483.

8. Collagen secretion screening in Drosophila supports a common secretory machinery and multiple Rab requirement.

Ke H, Feng Z, Liu M, Sun T, Dai J, Ma M, Liu L-P, Ni J-Q, Pastor-Pareja JC*.

J Genet Genom (2018) 45:299-313.

9. Inter-adipocyte adhesion and signaling by Collagen IV concentrations in Drosophila.

Dai J, Ma M, Feng Z, Pastor-Pareja JC*.

Curr Biol (2017) 27:1-12.

10. Basement membrane manipulation in Drosophila wing discs affects Dpp retention but not growth mechanoregulation.

Ma M, Cao, Dai J, Pastor-Pareja JC*.

Dev Cell (2017) 42:97-106.

11. Tango1 spatially organizes ER exit sites to control ER export.

Liu M‡, Feng Z‡, Ke H, Liu Y, Sun T, Dai J, Cui W, Pastor-Pareja JC*.

J Cell Biol (2017) 216:1035-59.

12. Plasma membrane overgrowth causes fibrotic collagen accumulation and immune activation in Drosophila adipocytes.

Zang Y‡, Wan M‡, Liu M, Ke H, Ma S, Liu LP, Ni JQ, Pastor-Pareja JC*.

eLIFE (2015) 10.7554/eLife.07187.

●  联系方式：

通讯地址：清华大学医学科学楼D224，北京 100084
电话：010-62783498（办公室）  010-62783597（实验室）
邮箱：josepastor@tsinghua.edu.cn
网址：http://joselab.life.tsinghua.edu.cn