颜宁

教授,博士生导师

1996.09—2000.07         学士,清华大学生物科学与技术系

2000.08—2004.12         博士,美国普林斯顿大学分子生物学系

2005.01—2007.09         博士后,美国普林斯顿大学分子生物学系

2007.10—2017.03         清华大学医学院,教授、博导

2017.04—2017.05         清华大学生命科学学院,教授、博导

 

● 研究兴趣、领域:

物质的跨膜运输是维持所有物种正常生命活动的基本过程之一,跨膜运输蛋白作为位于细胞膜和细胞器膜的重要功能蛋白维持细胞正常生命过程,并完成诸如信号传导、能量转化、新陈代谢等基本生理活动,我们主要运用结构生物学和生物化学手段系统研究跨膜运输蛋白的结构与机理。

主要研究方向如下:

1.        与疾病相关重要膜转运蛋白的结构与功能的研究;

2.        电压门控离子通道的结构与工作机理;

3.        胆固醇代谢调控机理。

 

● 代表性论文:

1.        Huaizong Shen, Qiang Zhou, Xiaojing Pan, Zhangqiang Li, Jianping Wu, Nieng Yan#. (2017) Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution. Science, 355(6328), eaal4326.

2.        Wei Peng, Huaizong Shen, Jianping Wu, Wenting Guo, Xiaojing Pan, Ruiwu Wang, S. R. Wayne Chen#, Nieng Yan#. (2016) Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2. Science, 354(6310), aah5324.

3.        Jianping Wu, Zhen Yan, Zhangqiang Li, Xingyang Qian, Shan Lu, Mengqiu Dong, Qiang Zhou & Nieng Yan#. (2016) Structure of the voltage-gated calcium channel Cav1.1 at 3.6?? resolution. Nature, 537(7619), 191–196.

4.        Xin Gong, Hongwu Qian, Xinhui Zhou, Jianping Wu, Tao Wan, Pingping Cao, Weiyun Huang, Xin Zhao, Xudong Wang, Peiyi Wang, Yi Shi, George F. Gao, Qiang Zhou#, Nieng Yan#. (2016) Structural insights into the Niemann-Pick C1 (NPC1)-mediated cholesterol transfer and Ebola infection. Cell, 165(6), 1467-1478.

5.        Jianping Wu, Zhen Yan, Zhangqiang Li, Chuangye Yan, Shan Lu, Mengqiu Dong, and Nieng Yan#. (2015) Structure of the voltage-gated calcium channel Cav1.1 complex. Science, 350(6267), aad2395.

6.        Dong Deng, Pengcheng Sun, Chuangye Yan, Meng Ke, Xin Jiang, Lei Xiong, Wenlin Ren, Kunio Hirata, Masaki Yamamoto, Shilong Fan & Nieng Yan#. (2015) Molecular basis of ligand recognition and transport by glucose transporters. Nature, 526(7573), 391-396.

7.        Ruobing Ren, Xinhui Zhou, Yuan He, Meng Ke, Jianping Wu,Xiaohui Liu, Chuangye Yan, Yixuan Wu, Xin Gong, Xiaoguang Lei, S. Frank Yan, Arun Radhakrishnan, Nieng Yan#. (2015) Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels. Science, 349(6244), 187-191.

8.        Zhen Yan, Xiao-chen Bai, Chuangye Yan, Jianping Wu, Zhangqiang Li, Tian Xie,  Wei Peng, Chang-cheng Yin, Xueming Li, Sjors H. W. Scheres#, Yigong Shi# & Nieng Yan#. (2015) Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution. Nature, 517(7532), 50-55.

9.        Dong Deng, Chao Xu, Pengcheng Sun, Jianping Wu, Chuangye Yan, Mingxu Hu & Nieng Yan#. (2014) Crystal structure of the human glucose transporter GLUT1. Nature, 510(7503), 121-125.

10.    Ping Yin, Quanxiu Li, Chuangye Yan, Ying Liu, Junjie Liu, Feng Yu, Zheng Wang, Jiafu Long, Jianhua He, Hong-Wei Wang, Jiawei Wang, Jian-Kang Zhu, Yigong Shi & Nieng Yan#. (2013) Structural basis for the modular recognition of single-stranded RNA by PPR proteins.Nature, 504(7478), 168-171.

11.    Linfeng Sun, Xin Zeng, Chuangye Yan, Xiuyun Sun, Xinqi Gong, Yu Rao, and Nieng Yan#. (2012) Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature, 490(7420), 361-366.

12.    Xu Zhang, Wenlin Ren, Paul DeCaen, Chuangye Yan, Xiao Tao, Lin Tang, Jingjing Wang, Kazuya Hasegawa, Takashi Kumasaka, Jianhua He, Jiawei Wang, David E. Clapham, and Nieng Yan#. (2012) Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature, 486(7401), 130-134.

13.    Dong Deng, Chuangye Yan, Xiaojing Pan, Magdy Mahfouz, Jiawei Wang, Jian-Kang Zhu, Yigong Shi#, and Nieng Yan#. (2012) Structural basis for the specific recognition of DNA by TAL effectors. Science, 335(6069), 720-723.

14.    Feiran Lu, Shuo Li, Yang Jiang, Jing Jiang, He Fan, Guifeng Lu, Dong Deng, Shangyu Dang, Xu Zhang, Jiawei Wang, and Nieng Yan#. (2011) Structure and mechanism of the uracil transporter UraA. Nature, 473(7342), 243-246.

15.    Shangyu Dang, Linfeng Sun, Feiran Lu, Jiawei Wang#, and Nieng Yan#. (2010) Structure of a fucose transporter in an outward-open conformation. Nature, 467(7316), 734-738.

16.    Shiqian Qi, Yuxuan Pang, Qun Liu, Hua Li, Yexing Liu, Quan Hao, Huilin Li, Nieng Yan#and Yigong Shi#. (2009) Crystal Structure of the Caenorhabditis elegans Apoptosome Reveals an Octameric Assembly of CED-4. Cell, 141(3), 446-457.

17.    Yi Wang, Yongjian Huang, Jiawei Wang, Chao Cheng, Weijiao Huang, Peilong Lu, Ya-Nan Xu, Pengye Wang, Nieng Yan# and Yigong Shi#. (2009) Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel. Nature, 462 (7272), 467-472.

 

 

● 联系方式:

电话:+86-10-62771298 (lab)

传真:+86-10-62792736

E-mail:structure (at) tsinghua.edu.cn