祁海

博士、教授

1991-1996,就读于北京医科大学临床医学系,获医学学士学位。
1997-2003,就读于University of Texas Medical Branch,获病理学博士学位。
2003-2009, Postdoctoral fellow, Laboratory of Immunology, NIAID/NIH
2009-至今,清华大学教授。

● 研究兴趣、领域:

综合运用分子与细胞免疫学手段、基因工程小鼠模型、以及基于双光子显微镜的活体成像技术,本实验室致力于研究免疫细胞相互作用、黏附、迁徙、以及反应性组织结构生成的机制。我们同时探索这些机制在诸如先天性免疫缺陷及自身免疫病等免疫病理过程中的作用。

● 代表性论文:

  Dan Liu*, Heping Xu*, Changming Shih, Zurong Wan, Xiaopeng Ma, Weiwei Ma, Dan Luo, and Hai Qi#. T-B cell entanglements and ICOSL-driven feed-forward regulation of germinal centre reaction. Nature, 2014 (Oct 15, Epub ahead of print, doi:10.1038/nature13803).

2.       Coco Chu, Yifeng Wang, Xu Zhang, Xinya Ni, Junxia Cao, Wan Xu, Zhongjun Dong, Pengfei Yuan, Wensheng Wei, Yuanwu Ma, Lianfeng Zhang, Longyan Wu, and Hai Qi#. SAP-regulated T cell-APC adhesion and ligation-dependent and -independent Ly108-CD3? interactions. Journal of Immunology, 193:3860-3871, 2014 (Sep 12, Epub ahead of print, doi:10.4049/jimmunol.1401660)

3.       Hai Qi#, Wolfgang Kastenmuller# and Ronald N Germain#. Spatio-temporal basis of innate and adaptive immunity in secondary lymphoid tissue. Annual Review of Cell and Developmental Biology, 2014 (Aug 8, Epub ahead of print, doi: 10.1146/annurev-cellbio-100913-013254)

4.       Hai Qi#, Dan Liu, Weiwei Ma, Yifeng Wang, Hu Yan. Bcl-6 controlled TFH polarization and memory: the known unknowns. Current Opinion in Immunology, 28:34-41, 2014

5.       Heping Xu, Xuanying Li, Dan Liu, Jianfu Li, Xu Zhang, Xin Chen, Shiyue Hou, Lixia Peng, Chenguang Xu, Wanli Liu, Lianfeng Zhang, and Hai Qi#. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature 496:523-527, 2013.

6.       Hai Qi#. From SAP-less T cells to helpless B cells and back: dynamic T-B interactions in germinal center development. Immunological Reviews 247:24-35, 2012.

7.       Hai Qi*, Jennifer L. Cannons*, Frederick Klauschen, Pamela L. Schwartzberg, and Ronald N. Germain. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature455:764-769, 2008.

8.       Hai Qi, Jackson G. Egen, Alex Y. C. Huang, and Ronald N. Germain. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 312:1672-1676, 2006.

 

● 联系方式:

电话:+86-10-62796757
电子邮件:qihai@mail.tsinghua.edu.cn