王钊

教授、博士生导师

1978-1983,河南中医学院医疗系,医学学士。 
1984-1987,北京中医药大学基础医学院,医学硕士。 
1990-1993,日本冈山大学药学院,药学硕士。 
1993-1996,日本冈山大学药学院,药学博士。 
1996-1998,日本冈山大学医学院,助理教授。 
1998-现在,清华大学生命科学学院副教授、教授、校内双聘教授。
2004-现在,清华大学医学院教授。
2006-2007,美国纽约大学西奈山医学院,访问教授。

● 研究兴趣、领域:

分子细胞药理毒理学:中药的药理与毒理、神经药理、肿瘤药理、骨代谢与药物干预等; 
衰老机制及药物干预的研究:尤其是脑衰老及药物对神经退行性疾病等衰老相关疾病的研究; 
天然药物与功能保健品的研究与开发。

● 代表性论文:

 ·Jing Du, Junlei Chang, Songxi Guo, Qing Zhang, Zhao Wang*. ApoE4 Reduces the  degrading enzyme IDE by Activating the NMDA Receptor in?Expression of A Hippocampal Neurons. Neuroscience Letters. (2009) (in press) 
 ·Jing Du, Bing Sun, Kui Chen, Li Fan, Zhao Wang*. Antagonist of Peroxisome Proliferator-activated Receptor <gamma> Induces Cerebellar Amyloid-<beta> Levels and Motor Dysfunction in APP/PS1 Transgenic Mice. Biochem Bioph Res Co. 384 (3): 357-361  (2009) 
 ·Zong-Chun Yi, Yan-Ze Liu, Hai-Xia Li, Zhao Wang*. Chebulinic acid and tellimagrandin I inhibit DNA strand breaks by hydroquinone/Cu(II) and H2O2/Cu(II), but potentiate DNA strand breaks by H2O2/Fe(II). Toxicology in Vitro. 23 (4) 667–673 (2009) 
 ·Jing Du, Bing Sun, Kui Chen, Lang Zhang, Shubo Liu, Qingquan Gu, Li Fan, Nanming Zhao, Zhao Wang*. Metabolites of Neurons Play Essential Role in Pathogenesis of Alzheimer's Disease. PLoS ONE. 4 (5): e5530 (2009) 
 ·Jing Du, Lang Zhang, Shubo Liu, Chi Zhang, Xiuqing Huang, Jian Li, Nanming  Transcriptionally Regulates the Expression of?Zhao, Zhao Wang*. PPAR Insulindegrading Enzyme in Primary Neurons. Biochem Bioph Res Co. 383 (4): 485-490  (2009) ··Min Fu, Ruxin Li, Li Fan, Guowei He, Kent L Thornburg, Zhao Wang*: Sarcoplasmic Reticulum Ca2+ Release Channel Ryanodine Receptor (RyR2) Plays a Crucial Role in Aconitine-induced Arrhythmias. Biochemical Pharmacology. 75 (11) 2147-2156 (2008) 
 ·Mingchao XIE, Chao AI, Shangfeng LIU, Shixin TAO, Zhao WANG*Cloning and characterization of chicken SPATA4 gene and analysis of its specific expression. Molecular and Cellular Biochemistry. 306 (1-2): 79-85  (2007) 
 ·Min Fu, Meng Wu, Jifeng Wang, Yanjiang Qiao, Zhao Wang*: Disruption of the Intracellular Ca2+ Homeostasis in the Cardiac Excitation-Contraction Coupling is a Crucial Mechanism of Arrhythmic Toxicity in Aconitine-induced Cardiomyocytes. Biochem Bioph Res Co. 354 (4): 929-936  (2007) 
 ·Liu Hai-Luo, Liu Shang-Feng, Ge Ye-Jing, Liu Jing, Wang Xiao-Yan, Xie Li-Ping, Zhang Rong-Qing, Wang Zhao*: Identification and characterization of a biomineralization related gene PFMG1 highly expressed in the mantle of pinctada fucata. Biochemistry. 46 (3): 844-851  (2007) 
 ·Zong-Chun Yi, Zhao WANG*, Hai-Xia Li, Yan Yin,  Feng-Yuan Zhuang,  and Yu-Bo Fan: Tellimagrandin I enhances gap junctional communication and attenuates the tumor phenotype of human cervical carcinoma HeLa cells in vitro. Cancer Letters. 242 (1)77-87 (2006) 
 ·Ming-Jie LIU, Patrick Ying-Kit YUE, Zhao WANG and Ricky Ngok-Shun WONG: Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria. Cancer Letters. 224 (2) 229-241 (2005) 
 ·Ming-Jie LIU, Zhao WANG*, Yong JU, Ricky Ngok-Shun WONG, Qing-Yu WU: Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis. Cancer Chemotherapy and Pharmacology. 55 (1) 79-90 (2005) 
 ·Rong-Cong Wu, Zhao Wang*, Ming-Jie Liu, Di-Fei Chen, Xiao-Shan Yue: 2-integrins mediate a novel form of chemoresistance in cycloheximide-induced U937 apoptosis. Cellular and Molecular Life Sciences. 61 (16) 2071-2082 (2004) 
 ·Shangfeng Liu, Luyun Li, Liu Gang, Xiaowei Xing, Guangxiu Lu, Zhao Wang*: Cloning of a full length cDNA of human testis-specific spermatogenic cell apoptosis inhibitor TSARG2 as candidate oncogene. Biochemical and Biophysical Research Communications (BBRC). 319, 32-40 (2004) 
 ·Zongchun Yi, Zhao Wang*, Haixia Li, Mingjie Liu: Inhibitory Effect of Tellimagrandin I on Chemically Induced Differentiation of Human Leukemia K562 Cells. Toxicology Letter. 147 (2) 109-119 (2004) 
 ·Ming-Jie Liu, Zhao Wang*, Hai-Xia Li, Rong-Cong Wu, Yan-Ze Liu, Qing-Yu Wu: Mitochondrial dysfunction as an early event in the process of apoptosis induced by Woodfordin I in human leukemia K562 cells. Toxicology and Applied Pharmacology. 194 (2) 141-155 (2004) (cover) 
 ·Mingjie Liu, Zhao Wang*, Rongcong Wu, Suqin Sun, Qingyu Wu: Monitoring all-trans-retinoic acid-induced differentiation of human acute promyelocytic leukemia NB4 cells by Fourier-transform infrared spectroscopy. Leukemia. 17 1670-1674 (2003) 

● 联系方式:

电话:+86-10-62772240
传真:+86-10-6277675
E-mail: tcm@tsinghua.edu.cn