董晨

教授,博导

2017/02-至今      北京市”慢性疾病的免疫学研究”重点实验室, 主任

2016/09-至今      清华大学医学院院长

2016/01-2016/09 清华大学医学院常务副院长

2015-至今            北大 - 清华生命科学联合中心副主任(清华)

2014-至今            清华大学免疫学研究所所长

2013-2016           清华大学医学院副院长

2013-至今            清华大学医学院教授

2010-2013           美国德克萨斯大学安德森肿瘤中心讲席教授

2008-2013           美国德克萨斯大学安德森肿瘤中心炎症与肿瘤中心主任

2008-2013           美国德克萨斯大学安德森肿瘤中心免疫学系终身教授

2004-2008           美国德克萨斯大学安德森肿瘤中心免疫学系终身副教授

2000-2004           美国华盛顿大学(西雅图)免疫学系助理教授

1997-2000           美国耶鲁大学医学院免疫系博士后

1990-1996           美国阿拉巴马大学伯明翰分校细胞及分子生物学专业博士

1985-1989           中国武汉大学细胞生物学专业学士

● 研究兴趣、领域:

董教授主要致力于免疫学的研究,重点探讨免疫耐受和免疫应答的分子调控机制, 以理解自身免疫和过敏疾病的发病机理, 并探索新型肿瘤免疫治疗。董晨教授是 Th17 细胞分化、调节和功能研究领域的奠基者和研究权威之一 , 并在 Tfh 和 Tfr 细胞的发现和研究中,做出了开创性贡献。他的主要研究领域包括:

1. T细胞分化和功能调控;

2. 细胞因子在炎症的功能及其机制;

3. 免疫耐受与肿瘤免疫治疗.

● 代表性论文:

1.      Xu, M., Lu, H., Wu, Y., Liu, K., Shi, Y., An, H., Zhang, J., Wang, X., Lai, Y. and Dong, C. An IL-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation. (2018) Immunity. 48(4):787-7982.

2.      Jing Li, Younghee, Lee, Yanjian Li, Yu Jiang, Huiping Lu, Wenjuan Zang, Xiaohong Zhao, Liguo Liu, Yang Chen, Haidong Tan, Zhiying Yang, Michael Q. Zhang, Tak W. Mak, Ling Ni and Chen Dong. Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells. (2018) Immunity. 48(4):773-7863.

3.      Jiang, Y., Liu, Y., Lu, H., Sun, S.-C., Jin, W., Wang, X. and Dong, C. Epigenetic activation during T helper 17 (Th17) cell differentiation is mediated by Tripartite motif containing 28. (2018) Nature Communications. 9:1424

4.      Weiwei Fu, Xindong Liu, Xiang Lin, Han Feng, Lin Sun, Shuran Li, Hairong Chen, Hong Tang, Liwei Lu, Wei Jin, Chen Dong. Deficiency in T follicular regulatory cells promotes autoimmunity. (2018) Journal of Experimental Medicine. 215:815-825

5.      Tao Xu(#), Kelly M. Stewart(#), Xiaohu Wang(#), Kai Liu, Min Xie, Jae Kyu Ryu, Ke Li, Tianhua Ma, Haixia Wang, Lu Ni; Saiyong Zhu, Nan Cao, Dongwei Zhu, Yu Zhang, Katerina Akassoglou, Chen Dong(*), Edward M. Driggers(*), Sheng Ding(*). Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism. (2017) Nature. 548:228-233. (* co-correspondent authors)

6.      Xiao Ding,Aibo Wang,Xiaopeng Ma,Maud Demarque,Jin Wei,Huawei Xin, Anne De jean,Chen Dong. Protein SUMOylation is required for regulatory T cell expansion and function. (2016) Cell Reports. 16:1055-1066.

7.      Xindong Liu, Huiping Lu, Tingting Chen, Kalyan C Nallaparaju, Xiaowei Yan, Shinya Tanaka,  Kenji Ichiyama, Xia Zhang, Li Zhang, Xiaofeng Wen, Qiang, Tian, Xiu-Wu Bian, Wei Jin,  Lai Wei, Chen Dong. Genome-wide analysis identifies Bcl6-controlled regulatory networks during T follicular helper (Tfh) cell differentiation. (2016) Cell Reports. 14:1735-1747

8.      Xindong Liu, Xin Chen, Bo Zhong, Aibo Wang, Xiaohu Wang, Fuliang Chu, Roza I Nurieva, Xiaowei Yan, Ping Chen, Laurens G van der Flier, Hiroko Nakatsukasa, Sattva S Neelapu, Wanjun Chen, Hans Clevers, Qiang Tian, Hai Qi, Lai Wei, Chen Dong. Transcription factor Achaete-Scute homologue 2 initiates T follicular helper cell development. (2014) Nature. 507: 513–518

 

● 荣誉、奖励及参加学术团体的情况:

2017                    Highly Cited Researcher, Clarivate Analytics

2016                    Highly Cited Researcher, Thomson Reuters

2016                    Keynote speaker, 2016 Keystone Symposium on T Follicular Helper Cells and Germinal Centers

2015                    Highly Cited Researcher, Thomson Reuters

2014                    Highly Cited Researcher, Thomson Reuters

2013                    Bayer Chair Professor, Tsinghua University

2012                    National Talent Recruitment (Qian Ren) Program awardee

2011                    Fellow, American Association for the Advancement of Science

2009                    American Association of Immunologists-BD Biosciences Investigator Award

2008-2013           Leukemia and Lymphoma Society Scholar Award

2007-2010           American Lung Association Career Investigator Award

2004                    Milstein Young Investigator award, International Society of Interferon and Cytokine Research

2003-2009           Cancer Research Institute Investigator Award

2002                    Young Investigator Award (1st Prize), International Cytokine Society

2000 –2005         Arthritis Investigator Award, Arthritis Foundation

● 联系方式:

Email: chendong at tsinghua.edu.cn

Phone: +86-10-62798095