谢道昕 博士

教授,博士生导师,教育部长江学者特聘教授,国家杰出青年基金获得者,Science China Life Sciences, Molecular Plant, Journal of Genetics and Genomics和The Plant Journal等学术期刊编委

2006-现在:清华大学(“百人计划”责任教授)

2002-2006:新加坡分子细胞生物所(实验室主任,资深科学家)

1999-2002:新加坡国立大学农业分子生物所(实验室主任,助理教授)

1994-1999:英国East Anglia大学(Senior Research Associate)

1990-1994:英国John Innes研究中心和英国Leicester大学(Research Associate)

1984-1990:中国农科院研究生院(MSc., Ph.D.)

1983-1984:湖南棉花科学研究所(Research Assistant)

1979-1983:湖南农学院(BSc.)

 

● 研究兴趣、领域:

激素对于生物的生长发育、新陈代谢和繁衍生息等各种生命活动起重要调节作用;阐明激素的受体识别机制,对于揭示生命现象的本质、提高生物的生存和发展能力具有重要意义。谢道昕实验室主要研究激素感知及其调控植物生长发育和防御反应的分子机制,迄今阐明了茉莉素(JA)和独脚金内酯(SL)两类激素的受体识别机制:茉莉素受体COI1结合茉莉素活性分子形成JA-COI1界面,招募抑制蛋白JAZ进行降解,触发信号传导链、调控植物的防御反应和生长发育;独脚金内酯受体D14是既作为水解酶催化独脚金内酯的水解反应、又作为受体感知独脚金内酯的新型激素受体,D14蛋白水解独脚金内酯,发生重大构象变化,形成了催化中心共价结合水解中间产物分子的"闭合状态"新界面,进而结合F-box蛋白D3/MAX2等蛋白、触发信号传导链,调控植物分枝。

● 代表性论文:

1.     Yan C, Fan M, Yang M, Zhao J, Zhang W, Su Y, Xiao L, Deng H and Xie D. (2018). Injury Activates Ca2+/Calmodulin-Dependent Phosphorylation of JAV1-JAZ8-WRKY51 Complex for Jasmonate Biosynthesis. Molecular Cell, 70(1), 136-149.

2.     Yao R, Chen L and Xie D. (2018). Irreversible strigolactone recognition: a non-canonical mechanism for hormone perception. Current Opinion in Plant Biology, 45, 155-161.

3.     Yao R, Wang F, Ming Z, Du X, Chen L, Wang Y, Zhang W, Deng H and Xie D. (2017). ShHTL7 is a non-canonical receptor for strigolactones in root parasitic weeds. Cell Research, 27(6), 838.

4.         Wu D, Qi T, Li W, Tian H, Gao H, Wang J, Ge J, Yao R, Ren C, Wang X, Liu Y, Kang L, Ding S and Xie D. (2017) Viral effector protein manipulates host jasmonate signaling to attract insect vectors. Cell Research, 27(3), 402.

5.         Yao R, Ming Z, Yan L, Li S, Wang F, Ma S, Yu C, Yang M, Chen L, Chen L, Li Y, Yan C, Miao D, Sun Z, Yan J, Sun Y, Wang L, Chu J, Fan S, He W, Deng H, Nan F, Li J, Rao Z, Lou Z and Xie D. (2016) DWARF14 is a non-canonical hormone receptor for strigolactone. Nature, 536(7617), 469. (Featured in Nature and Science Signaling)

6.         Qi T, Wang J, Huang H, Liu B, Gao H, Liu Y, Song S and Xie D. (2015) Regulation of Jasmonate-Induced Leaf Senescence by Antagonism between bHLH Subgroup IIIe and IIId Factors in Arabidopsis. Plant Cell, 27(6), 1634-1649.

7.         Qi T, Huang H, Song S and Xie D. (2015) Control of Jasmonate-regulated Stamen Development and Seed Production by a bHLH-MYB Complex in Arabidopsis. Plant Cell, 27(6), 1620-1633.

8.         Qi T, Huang H, Wu D, Yan J, Qi Y, Song S and Xie D. (2014). Arabidopsis DELLA and JAZ Proteins Bind the WD-repeat/bHLH/MYB Complex to Modulate Gibberellin and Jasmonate Signaling Synergy. Plant Cell, 26(3), 1118-1133.

9.        Song S, Huang H, Gao H, Wang J, Wu D, Liu X, Yang S, Zhai Q, Li C, Qi T and Xie D. (2014) Interaction of MYC2 with EIN3 Modulates Antagonism between Jasmonate and Ethylene Signaling. Plant Cell, 26(1), 263-279.

10.        Hu P, Zhou W, Cheng Z, Fan M, Wang L and Xie D. (2013) JAV1 controls Jasmonate-regulated plant defense. Molecular Cell, 50(4), 504-515 (cover story; featured in Mol. Cell)

11.        Song S, Qi T, Wasternack C. and Xie D. (2014). Jasmonate signaling and crosstalk with gibberellin and ethylene. Current Opinion in Plant Biology, 21, 112-119.

12.      Yan J, Li H, Li S, Yao R, Deng H, Xie Q and Xie D. (2013) The Arabidopsis F-box protein CORONATINE INSENSITIVE 1 is stabilized by SCFCOI1 and degraded via the 26S proteasome pathway. Plant Cell, 25(2), 486-498. (recommended by Faculty 1000)

13.      Song S, Qi T, Fan M, Zhang X, Gao H, Huang H, Wu D, Guo H and Xie D. (2013) The bHLH Subgroup IIId Factors Negatively Regulate Jasmonate-mediated Plant Defense and Development. PLoS Genetics, 9(7), e1003653.

14.      Qi T, Song S, Ren Q, Wu D, Huang H, Chen Y, Fan M, Peng W, Ren C and Xie D. (2011) The Jasmonate-ZIM-domain Proteins Interact with the WD-repeat/bHLH/MYB Complexes to Control Jasmonate-regulated Anthocyanin Accumulation and Trichome Initiation in Arabidopsis. Plant Cell, 23(5), 1795-1814.

15.     Shan X, Yan J and Xie D. (2012) Comparison of phytohormone signaling mechanisms. Current Opinion in Plant Biology, 15(1), 84-91.

16.      Song S, Qi T, Huang H, Ren Q, Wu D, Chang C, Peng W, Liu Y, Peng J and Xie D. (2011) The Jasmonate-ZIM-domain Proteins Interact with the R2R3-MYB Transcription Factors MYB21 and MYB24 to Control Jasmonate-regulated Stamen Development in Arabidopsis. Plant Cell, 23(3), 1000-1013.

17.      Yan J, Zhang C, Gu M, Bai Z, Zhang W, Qi T, Cheng Z, Peng W, Luo H, Nan F, Wang Z and Xie D. (2009) The Arabidopsis CORONATINE INSENSITIVE 1 protein is a jasmonate receptor. Plant Cell, 21(8), 2220-2236 (recommended by Faculty 1000, featured in Nat. Chem. Bio. and Plant Cell)

18.      Cheng H, Song S, Xiao L, Soo H, Cheng Z, Xie D and Peng J. (2009) Gibberellin Acts Through Jasmonate to Control the Expression of MYB21, MYB24 and MYB57 to Promote Stamen Filament Growth in Arabidopsis. PLoS Genetics, 5(3), e1000440.

19.      Tan L, Li X, Liu F, Sun X, Li C, Zhu Z, Fu Y, Cai H, Wang X, Xie D and Sun C. (2008) Control of a key transition from prostrate to erect growth in rice domestication. Nature Genetics, 40(11), 1360-1364.

20.      Xiao S, Dai L, Liu L, Wang Z, Peng W and Xie D. (2004) COS1: an Arabidopsis coi1 suppressor essential forregulation of jasmonate-mediated plant defense and senescence. Plant Cell, 16(5), 1132-1142.

21.      Liu F, Ni W, Griffith M E, Huang Z, Chang C, Peng W, Ma H and Xie D. (2004) The ASK1 and ASK2 Genes Are Essential for Arabidopsis Early Development. Plant Cell, 16(1), 5-20.

22.      Xu L, Liu F, Lechner E, Genschik P, Crosby W L, Ma H, Peng W, Huang D and Xie D. (2002) The SCF (COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. Plant Cell, 14(8), 1919-1935.

23.      Xie D, Feys F, James S, Nieto-Rostro M and Turner J. (1998) COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertility. Science, 280(5366), 1091-1094.

 

 

 

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