戚益军 教授

长江学者特聘教授,国家杰出青年基金获得者

1998-2001,浙江大学生物技术研究所,博士

1995-1998,原浙江农业大学生物技术研究所,硕士

1991-1995,南京农业大学植物保护系,本科

2011-现在,清华大学生命科学学院,教授

2010-2011,北京生命科学研究所,高级研究员

2006-2010,北京生命科学研究所,研究员

2004-2006 ,美国冷泉港实验室,博士后

2001-2004,美国俄亥俄州立大学,博士后

 

● 研究兴趣、领域:

植物小RNA与长非编码RNA的生物学功能和作用机制、植物表观遗传的作用机制。

● 开设的课程:

高级植物生物学、RNA生物学

● 代表性论文:

Fang X., Zhao, G., Zhang, S., Li, Y., Gu, H., Li, Y., Zhao, Q. and Qi, Y.* (2018) A chloroplast retrograde signaling pathway regulates nuclear microRNA biogenesis. Molecular Cell, revised.

Li, Y.#, Yuan, Y.#, Fang, X.#, Lu, X., Lian, B., Zhao, G. and Qi, Y.* (2018) A role for MINIYO and QUATRE-QUART 2 in the assembly of RNA polymerases II, IV and V in Arabidopsis. The Plant Cell, 30: 466-480.

Liu, C.#, Xin, Y.#, Xu, L.#, Cai, Z., Xue, Y., Liu, Liu, C., Xin, Y., Xu, L., Cai, Z., Xue, Y., Liu, Y., Xie, D., Liu, Y. and Qi, Y.* (2018) Arabidopsis ARGONAUTE1 binds chromatin to promote gene transcription in response to hormone and stress stimuli. Developmental Cell, 44: 348-361.

Yuan, J. #, Li, J. #, Yang, Y., Tan, C., Zhu, Y., Hu, L., Qi, Y. * and Lu, Z.* (2018) Stress-responsive regulation of long noncoding RNA polyadenylation in Oryza sativa. The Plant Journal, 93: 814-827.

Xu, L.#, Hu, Y.#, Cao, Y., Li, J., Ma, L., Li, Y.* and Qi Y. * (2018) An expression atlas of miRNAs in Arabidopsis thaliana. Science China Life Sciences, 61: 178-189.

Liu, M., Ba, Z., Costa-Nunes, P., Wei, W., Li, L., Kong, F., Li, Y., Chai, J., Pontes, O. and Qi, Y. * (2017) IDN2 interacts with RPA and facilitates DNA double-strand break repair by homologous recombination in Arabidopsis. The Plant Cell, 29: 589-599.

Cui, Y.#, Fang, X.# and Qi, Y.* (2016) TRANSPORTIN1 Promotes the Association of MicroRNA with ARGONAUTE1 in Arabidopsis. The Plant Cell, 28: 2576-2585.

Fang, X. and Qi, Y.* (2016) RNAi in plants: An Argonaute-centered view. The Plant Cell, 28: 272-285. (invited review)

Ye, R.#, Chen, Z.#, Lian, B., Rowley, M., Xia, N., Chai, J., Li, Y., Wierzbicki A., and Qi, Y. * (2016) A Dicer-independent route for biogenesis of siRNAs that direct DNA methylation in Arabidopsis. Molecular Cell, 61: 222-235.

Fang, X., Cui, Y., Li, Y., and Qi, Y.* (2015) Transcription and processing of primary miRNAs are coupled by Elongator complex in Arabidopsis. Nature Plants, doi:10.1038/nplants.2015.75.

Fang, X., Lu, X., Chen, Z., and Qi, Y.* (2015) CMA33/XCT regulates small RNA production through modulating the transcription of Dicer-Like genes in Arabidopsis. Molecular Plant, 8: 1227-1236.

Yang, Y.* and Qi, Y.* (2015) RNA-directed repair of DNA double-strand breaks. DNA Repair, 32: 82-85.

Wu, J., Yang, Z., Wang, Y., Zheng, L., Ye, R., Ji, Y., Zhao, S., Ji, S., Liu, R., Xu, L., Zheng, H., Zhou, Y., Zhang, X., Cao, X., Xie, L., Wu, Z. *, Qi, Y.*, and Li, Y.* (2015) Viral-Inducible Argonaute18 confers broad-spectrum virus resistance in rice by sequestering a host microRNA. eLife, 10.7554/eLife.05733.

Gao, M. #, Wei, W. #, Li, M. #, Wu, Y., Ba, Z., Jin K.-X., Li, M.-M., Liao, Y.-Q., Adhikari S., Chong, Z., Zhang, T., Guo, C.-X., Tang, T.-S., Zhu, B.-T., Xu, X.-Z., Mailand, N., Yang, Y.*, Qi, Y.*, and Rendtlew Danielsen, J. (2014) Ago2 Facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination. Cell Research,24: 532-541.

Li, J., Wu, Y., and Qi, Y.* (2014) MicroRNAs in a multicellular green alga Volvox carteri. Science China Life Sciences, 57: 36-45.

Ba, Z., and Qi, Y.* (2013) Small RNAs: Emerging key players in DNA double-strand break repair. Science China Life Sciences, 56: 933-936.

Zhong, S., Liu, J., Jin, H., Lin, L., Li, Q., Chen, Y., Yuan, Y., Wang, Z., Huang, H., Qi, Y., Chen. X., Vaucheret H., Chory J., Li, J., and He. Z.* (2013). Warm temperatures induce transgenerational epigenetic release of RNA silencing by inhibiting siRNA biogenesis in Arabidopsis. PNAS, 110(22): 9171-9176.

Wu, X., Shi, Y., Li, J., Xu, L., Fang, Y., Li, X., and Qi, Y.* (2013). A role for the RNA-binding protein MOS2 in microRNA maturation in Arabidopsis. Cell Research,23: 645-657.

Ye, R. #, Wang, W. #, Iki, T., Liu, C., Wu, Y., Ishikawa M., Zhou, X., and Qi, Y.* (2012). Cytoplasmic assembly and selective nuclear import of Arabidopsis ARGONAUTE4/siRNA complexes. Molecular Cell, 46: 859-870.

     Highlighted in Molecular Cell 46: 719-721, 2012   

Wei, W. #, Ba, Z. #, Gao, M., Wu, Y., Ma, Y., Amiard, S., White, C., Danielsen, J., Yang, Y., and Qi, Y.* (2012). A role for small RNAs in DNA double-strand break repair. Cell, 149: 101-112.

     Highlighted in Nature Review Genetics 13:299, 2012; Nature Reviews Molecular Cell Biology 13: 282, 2012; and Nature Structural & Molecular Biology 19: 470, 2012

     Recommended on Faculty of 1000 ( http://f1000.com/prime/14263986)

Wu, L.*, Mao, L., and Qi, Y. (2012) Roles of DICER-LIKE and ARGONAUTE proteins in TAS-derived small interfering RNA-triggered DNA methylation. Plant Physiology, 160: 990-999.

Shen, H., He, H., Li, J., Chen, W., Wang, X., Guo, L., Peng, Z., He, G., Zhong, S., Qi, Y., Terzaghi, and W., Deng, X.* (2012) Genome-wide analysis of DNA methylation and gene expression changes in two Arabidopsis ecotypes and their reciprocal hybrids. Plant Cell 24: 875-892.

Wang, W. #, Ye, R. #, Xin, Y., Feng, X., Li, C., Zhou, X., and Qi, Y.* (2011). An Importin β protein negatively regulates microRNA activity in Arabidopsis. The Plant Cell, 23: 3565-3576. (Cover story)

Wang, Y., Itaya, A., Zhong, X., Wu, Y., Zhang, J., van der Knaap, E., Olmstead, R., Qi, Y., and Ding, B.* (2011). Function and evolution of a microRNA that regulates a Ca2+-ATPase and triggers the formation of phased small interfering RNAs in tomato reproductive growth. The Plant Cell, 23: 3185-3203.

Wu, L. #, Zhou, H. #, Zhang, Q., Ni, F., Liu, C., and Qi, Y.* (2010). DNA methylation mediated by a microRNA pathway. Molecular Cell, 38: 465-475. (Cover story)

     Highlighted in Cell, 141: 556, 2010.

Li, Y., Zhang, Q., Zhang, J., Wu, L., Qi, Y., and Zhou, J.* (2010). Identification of miRNAs involved in Pathogen-Associated Molecular Pattern-triggered plant innate immunity. Plant Physiology, 152: 2222-2231.

He, G., Zhu, X., Elling, A.A., Chen, L., Wang, X., Guo, L., Liang, M., He, H., Zhang, H., Chen, F., Qi, Y., Chen R., Deng, X.W.* (2010). Global epigenetic and transcriptional trends among two rice subspecies and their reciprocal hybrids. The Plant Cell, 22: 17-33.

Qi, Y.* and Mi, S. (2010). Purification of Arabidopsis Argonaute complexes and associated small RNAs. Methods in Molecular Biology, 592:243-254.

Wu, L., Zhang, Q., Zhou, H., Ni, F., Wu, X., and Qi, Y.* (2009). Rice microRNA effector complexes and targets. The Plant Cell, 21: 3421-3435.

Wei, B., Cai, T., Zhang, R., Li, A., Huo, N., Li, S., Gu, Y. Q., Vogel, J, Jia J., Qi, Y.*, Mao, L.* (2009). Novel microRNAs uncovered by deep sequencing of small RNA transcriptomes in bread wheat (Triticum aestivum L.) and Brachypodium distachyon (L.) Beauv. Functional and Integrative Genomics, 9: 499-511. (*co-corresponding authors)

Wang, X., Elling, A. A., Li, X., Li, N., Peng, Z., He, G., Sun, H., Qi, Y., Liu, S., Deng, X.W.* (2009). Genome-wide and organ-specific landscapes of epigenetic modifications and their relationships to mRNA and small RNA transcriptomes in maize. The Plant Cell, 21: 1053-1069.

Zhao, T., Wang, W., Bai, X., and Qi, Y.* (2009). Gene silencing by artificial microRNAs in Chlamydomonas. The Plant Journal, 58: 157-164.

Gruntman, E. #, Qi, Y. #, Slotkin, R., Roeder, T., Martienssen, R., and Sachidanandam, R.* (2008) Kismeth: Analyzer of plant methylation states through bisulfite sequencing. BMC Bioinformatics, 9:371. (*co-first authors)

Meyers, B.C.*, Axtell, M.J.*, Bartel, B., Bartel, D.P., Baulcombe, D., Bowman, J.L., Cao, X., Carrington, J.C., Chen, X., Green, P.J., Griffiths-Jones, S., Jacobsen, S.E., Mallory, A.C., Martienssen, R.A., Poethig, R.S., Qi, Y., Vaucheret, H., Voinnet, O., Watanabe, Y., Weigel, D., and Zhu, J.K. (2008). Criteria for annotation of plant microRNAs. The Plant Cell, 20: 3186-3190.

Mi, S. #, Cai, T. #, Hu, Y., Chen, Y., Hodges, E., Ni, F., Wu, L., Li, S., Zhou, H., Long, C., Chen, S., Hannon, G., and Qi, Y.* (2008) Sorting of small RNAs into Arabidopsis Argonaute complexes is directed by the 5’ terminal nucleotide. Cell, 133: 116-127. 

     This work was featured in Cell 133:25-26, 2008.

Zhao, T. #, Li, G. #, Mi, S., Li, S., Hannon, G., Wang, X.-J.*, and Qi, Y*. (2007). A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes and Development, 29: 1190-1203. (*co-corresponding authors)  

     Highlighted in: Cell 129:1029, 2007; Genes and Development 21: 1153-1156, 2007; Nature 447: 5, 2007; Nature 447: 518, 2007; Nature Review Genetics 8: 406, 2007; ACS Chemical Biology 2: 436-437, 2007

 

● 荣誉、奖励及参加学术团体的情况:

2010年获谈家桢生命科学创新奖

2011年获教育部长江学者特聘教授

2012年获国家杰出青年基金

2013年获中国青年科技奖

2015年国家自然科学基金“创新研究群体”学术带头人

2016年获国家自然科学奖二等奖(第一完成人)

 

● 联系方式:

地址:北京市海淀区清华大学生物技术馆4101-4106

E-mail: qiyijunATtsinghua.edu.cn