杨雪瑞 博士

研究员(PI),博导,青年千人

1999-2003  清华大学,化学工程系,学士
2003-2009  美国密歇根州立大学,化学工程系/生物化学及分子生物学系,双学科博士
2009-2012  美国哥伦比亚大学,Irving癌症研究中心,系统生物学联合中心,博士后
2012-至今  清华大学生命科学学院,研究员(PI)、博导

● 研究兴趣、领域:

利用交叉学科的优势,结合系统生物学,基因组学,生物信息学,遗传学,及分子与细胞生物学的方法,系统性地研究主要疾病,如癌症,在分子水平的基因调节通路与网络。同时,针对特定的重要基因及调节通路,开展深入的分子生物学研究,阐明其具体的作用机理,为疾病诊断及药物研发提供分子生物学基础。

实验室有机地结合计算与实验的优势,并开展广泛的合作研究。目前的研究集中于转录后(post-transcription)及转译(translation)相关的调节机理及其在肿瘤发生中的作用。

 

● 代表性论文:

1. Li, X., Wang, X., Song, W., Xu, H., Huang, R., Wang, Y., Zhao, W., Xiao, Z., and Yang, X.*, Oncogenic properties of NEAT1 in prostate cancer cells depend on the CDC5L-AGRN transcriptional regulation circuit. Cancer Research, 2018.6. DOI: 10.1158/0008-5472.CAN-18-0688.

2. Xiao, Z., Huang, R., Xing, X., Chen, Y., Deng, H., and Yang, X.*, De novo annotation and characterization of the translatome with ribosome profiling data. Nucleic Acids Res, 2018. 46(10): p. e61.

3. Chiu, H.S., Martinez, M.R., Komissarova, E.V., Llobet-Navas, D., Bansal, M., Paull, E.O., Silva, J., Yang, X.*, Sumazin, P.*, and Califano, A.*, The number of titrated microRNA species dictates ceRNA regulation. Nucleic Acids Res, 2018. 46(9): p. 4354-4369.

4. Xiao, Z., Zou, Q., Liu, Y., and Yang, X.*, Genome-wide assessment of differential translations with ribosome profiling data. Nat Commun, 2016. 7: p. 11194.

5. Lin, Z., Hsu, P.J., Xing, X., Fang, J., Lu, Z., Zou, Q., Zhang, K.J., Zhang, X., Zhou, Y., Zhang, T., Zhang, Y., Song, W., Jia, G., Yang, X.*, He, C.*, and Tong, M.H.*, Mettl3-/Mettl14-mediated mRNA N(6)-methyladenosine modulates murine spermatogenesis. Cell Res, 2017. 27(10): p. 1216-1230.

6. Zhang, Y., Xiao, Z., Zou, Q., Fang, J., Wang, Q., Yang, X.*, and Gao, N.*, Ribosome Profiling Reveals Genome-wide Cellular Translational Regulation upon Heat Stress in Escherichia coli. Genomics Proteomics Bioinformatics, 2017. 15(5): p. 324-330.

7. Xu, W., Xu, H., Li, K., Fan, Y., Liu, Y., Yang, X.*, and Sun, Q.*, The R-loop is a common chromatin feature of the Arabidopsis genome. Nat Plants, 2017. 3(9): p. 704-714.

8. Wu, J., Huang, B., Chen, H., Yin, Q., Liu, Y., Xiang, Y., Zhang, B., Liu, B., Wang, Q., Xia, W., Li, W., Li, Y., Ma, J., Peng, X., Zheng, H., Ming, J., Zhang, W., Zhang, J., Tian, G., Xu, F., Chang, Z., Na, J., Yang, X., and Xie, W.*, The landscape of accessible chromatin in mammalian preimplantation embryos. Nature, 2016. 534(7609): p. 652-7.

9. Wang, Y., Shi, J., Yan, J., Xiao, Z., Hou, X., Lu, P., Hou, S., Mao, T., Liu, W., Ma, Y., Zhang, L., Yang, X., and Qi, H.*, Germinal-center development of memory B cells driven by IL-9 from follicular helper T cells. Nat Immunol, 2017. 18(8): p. 921-930.

10. Chiu, H.S., Martinez, M.R., Bansal, M., Subramanian, A., Golub, T.R., Yang, X.*, Sumazin, P.*, and Califano, A.*, High-throughput validation of ceRNA regulatory networks. BMC Genomics, 2017. 18(1): p. 418.

11. Sumazin, P.#, Yang, X.#, Chiu, H.S.#, Chung, W.J., Iyer, A., Llobet-Navas, D., Rajbhandari, P., Bansal, M., Guarnieri, P., Silva, J., and Califano, A.*, An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma. Cell, 2011. 147(2): p. 370-81.

 


● 联系方式:

电话:+86-10-62783943
E-mail:yangxuerui@tsinghua.edu.cn