潘宪明 博士

教授,博导,国家杰出青年基金获得者

1978-1981年,复旦大学 学士
1982-1984年,北京大学 硕士
1986-1989年,德国Bochum大学 博士
现任清华大学教授

● 研究兴趣、领域:

生物化学,蛋白质折叠和蛋白质结构预测。

● 代表性论文:


?Sheng X. R., Zhang H. J., Pan X. M. and Zhou J.M. (1997) Domain movement in rabbit muscle adenylate kinase might involve proline isomerization. FEBS Letters, 413, 429-432.
?Zhang H. J., Sheng X. R., Pan X. M.* and Zhou J.M. (1997) Activation of adenylate kinase by denaturatants is due to the increasing flexibility at its active sites. BBRC, 238, 382-386.
?Zhang H. J., Sheng X. R., Niu W. D., Pan X. M.* and Zhou J.M. (1998) Rabbit Muscle Adenylate Kinase: Evidence for at Least Two Native forms in Equilibrium in Aqueous Solution. J. Biol. Chem., 273, 7448-7456.
?Zhang H. J., Sheng X. R., Pan X. M.* and Zhou J. M. (1998) Refolding of urea-denatured adenylate kinase. Biochem. J., 333, 401-405.
?Sheng X. R., Li X. and Pan X. M.* (1999) An Iso-random Bi Bi mechanism for adenylate kinase. J. Biol. Chem., 274, 22238-22243.
?Li X. and Pan X. M.* (2001) New Method for accurate prediction of solvent accessibility from protein sequence. Proteins, structure, Function, and Genetics, 42, 1-5.
?Pan X. M.* (2001) Multiple linear regression for protein secondary structure prediction. Proteins, structure, Function, and Genetics. 43,256-9
?Li X., Yang Han and Pan X. M.*(2001) Cysteine-25 of adenylate kinase reacts with dithiothreitol to form an adduct upon aging of the enzyme. FEBS Letters, 507 (2) 169-173.
?Han Y. , Li X. and Pan X. M.*(2002) Native States of adenylate kinase are two active sub-ensembles. FEBS Letter, 528 161-165
?Xu S., Qin S. and Pan X. M.* (2004)Thermal and Conformational Stability of Ssh10b Protein from Archaeon Sulfolobus shibattae. Biochem. J, 382, 433-440.
?Nan Zhang, Xian-Ming Pan*, Meng Ge*. Without salt, the ‘thermophilic’ protein mth10b is just mesophilic. PLoS ONE, 2012, 7(12):e53125.
?Jing Yang, Meng Ge, Xian-Ming Pan*. A time lag insensitive approach for estimating HIV-1 transmission direction. AIDS, 2012, 26(8): 921-928.
?Jing Yang, Xia-Yu Xia, Xiang He, Sen-Lin Yang, Yu-Hua Ruan, Quan-Bi Zhao, Zhi-Xin Wang, Yi-Ming Shao, Xian-Ming Pan*. A new pattern-based method for identifying recent HIV-1 infections from the viral sequence. SCIENCE CHINA-LIFE SCIENCES, 2012, 55 (4): 328-335.
?Yan-Feng Liu, Nan Zhang, Xi Liu, Xin-Quan Wang, Zhi-Xin Wang, Yuan-Yuan Chen, Hong-Wei Yao, Meng Ge, Xian-Ming Pan*. Molecular Mechanism Underlying the Interaction of Typical Sac10b Family Proteins with DNA. PLoS ONE, 2012, 7(4): e34986.
?Xia-Yu Xia, Meng Ge, Zhi-Xin Wang, Xian-Ming Pan*. Accurate Prediction of Protein Structural Class. PLoS ONE, 2012, 7(6): e37653.

 

● 联系方式:

电话:+86-10-62792827
传真:+86-10-62792827
E-mail:pan-xm@mail.tsinghua.edu.cn