龚海鹏 博士

研究员

1993-1997年 学士   清华大学生物科学与技术系

1997-2000年 硕士   清华大学生物科学与技术系

2000-2006年 博士   Johns Hopkins University, Program of Molecular Biophysics

2006-2007年 博士后 Johns Hopkins University, Program of Molecular Biophysics

2007-2009年 博士后 University of Chicago, Department of Biochemistry and Molecular Biology

2009-2014年 助理教授 清华大学生命学院

2015年至今 副教授 清华大学生命学院

 

● 研究兴趣、领域:

1.        用分子动态模拟(molecular dynamics simulation)研究生物大分子的动态和作用机理

2.        从氨基酸序列预测蛋白质的三维结构

 

● 代表性论文:

1.        Ruining Sun# and Haipeng Gong*, “Simulating the activation of voltage sensing domain for a voltage-gated sodium channel using polarizable force field”, Journal of Physical Chemistry Letters, 8: 901-908, 2017

2.        Yang Li#, Ruining Sun#, Huihui Liu, and Haipeng Gong*, “Molecular dynamics study of ion transport through an open model of voltage-gated sodium channel”, Biochimica et Biophysica Acta – Biomembranes, 1859(5): 879-887, 2017.

3.        Xiaoying Lv#, Hao Liu, Haifeng Chen, and Haipeng Gong*, “Coupling between ATP hydrolysis and protein conformational change in maltose transporter”, Proteins: Structure, Function and Bioinformatics, 85(2): 207-220, 2017.

4.        Tong Wang#, Yuedong Yang, Yaoqi Zhou, and Haipeng Gong*, “LRFragLib: an effective algorithm to identify fragments for de novo protein structure prediction”, Bioinformatics, 33(5): 677-684, 2017.

5.        Yang Li#, Huihui Liu#, Mengdie Xia, and Haipeng Gong*, “Lysine and the Na+/K+ selectivity in mammalian voltage-gated sodium channels”, PLoS One, 11(9): e0162413, 2016.

6.        Huihui Liu#, Yan-Song Gao#, Xiang-Jun Chen, Zhe Chen, Hai-Meng Zhou, Yong-Bin Yan*, and Haipeng Gong*, “A single residue substitution accounts for the significant difference in thermostability between two isoforms of human cytosolic creatine kinase”, Scientific Reports, 6: 21191, 2016.

7.        Yufeng Liu#, Meng Ke, and Haipeng Gong*, “Protonation of Glu135 facilitates the outward-to-inward structural transition of fucose transporter”, Biophysical Journal, 109(3): 542-551, 2015.

8.        Dapeng Xiong#, Jianyang Zeng, and Haipeng Gong*, “RBRIdent: an algorithm for improved identification of RNA-binding residues in proteins from primary sequences”, Proteins: Structure, Function and Bioinformatics, 83(6):1068-1077, 2015.

9.        Juanrong Zhang#, Wenzhi Mao#, Yanhui Ren#, Rui-Ning Sun, Nieng Yan*, and Haipeng Gong*, “Simulating the ion permeation and ion selection for a eukaryotic voltage-gated sodium channel NavPaS”, Protein & Cell, in press, 2018.

10.       Meng Ke#, Yafei Yuan, Xin Jiang, Nieng Yan*, and Haipeng Gong*, “Molecular determinants for the thermodynamic and functional divergence of uniporter GLUT1 and proton symporter XylE”, PLoS Computational Biology, 13(6): e1005603, 2017.

11.       Dapeng Xiong#, Jianyang Zeng*, and Haipeng Gong*, “A deep learning framework for improving long-range residue-residue contact prediction using a hierarchical strategy”, Bioinformatics, 33(17): 2675-2683, 2017.

 

● 联系方式:

办公地址:医学楼C308室

电话:010-62794753(office),010-62794737(lab)

Email: hgong@tsinghua.edu.cn