隋森芳 博士

教授,博士生导师
中科院院士

1964-1970    清华大学精密仪器系,学士

1978-1981    清华大学工程物理系,硕士

1985-1988    德国慕尼黑工业大学生物物理所,博士

1989-1991    清华大学生物科学与技术系,副教授

1991.1-至今 清华大学生命科学学院(2009年9月以前为生物科学与技术系),教授、博导

 

● 研究兴趣、领域:

我们利用冷冻电子显微学,结合生物化学、生物物理学和细胞生物学等技术手段,研究:

(1)蛋白质复合体、复杂蛋白质机器和膜蛋白的结构、功能与工作机制;

(2)囊泡运输中的分子机制,蛋白质与膜脂的相互作用,生物膜与重大疾病的关系。

● 代表性论文:

1.  Yang X, Yang F, Wang W, Lin G, Hu Z, Han Z, Qi Y, Zhang L, Wang J, Sui SF*, Chai J*. (2018) Structural basis for specific flagellin recognition by the NLR protein NAIP5. Cell Research, 28:35-47.

2.  Zhang J, Ma J, Liu D, Qin S, Sun S*, Zhao J, Sui SF*. (2017) Structure of phycobilisome from the red alga Griffithsia pacifica. Nature, 551:57-63.

3.  Sun S, Li L, Yang F, Wang X, Fan F, Yang M, Chen C, Li X, Wang HW, Sui SF*. (2017) Cryo-EM structures of the ATP-bound Vps4-E233Q hexamer and its complex with Vta1 at near-atomic resolution. Nat Commun., 8:16064.

4.  Zhang L, Wang X, Fan F, Wang HW, Wang J*, Li X*, Sui SF*. (2017) Cryo-EM structure of Nma111p, a unique HtrA protease composed of two protease domains and four PDZ domains. Cell Research, 27:582-585.

5.  Zhang J, Pan X, Yan K, Sun S, Gao N*, Sui SF*. (2015) Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps. eLife, 4: e09684.

6.  Hu Z, Zhou Q, Zhang C, Fan S, Cheng W, Zhao Y, Shao F, Wang HW, Sui SF*, Chai J*. (2015) Structural and Biochemical Basis for Induced Self-propagation of NLRC4.Science, 350:399-404.

7.  Chang L, Liu X, Li Y, Liu CC, Yang F, Zhao J*, Sui SF*. (2015) Structural organization of an intact phycobilisome and its association with photosystem II. Cell Research, 25:726-737.

8.  Zhou Q, Huang X, Sun S, Li X, Wang HW*, Sui SF*. (2015) Cryo-EM structure of SNAP-SNARE assembly in 20S particle. Cell Research, 25:551-560.

9.  Chang LF, Chen S, Liu CC, Pan X, Jiang J, Bai XC, Xie X, Wang HW, Sui SF*. (2012) Structural characterization of full-length NSF and 20 S particles. Nat Struct Mol Biol., 19:268-275.

● 联系方式:

电话:+86-10-62792083/62784768

E-mail: suisf@mail.tsinghua.edu.cn

Lab website: http://suilab.life.tsinghua.edu.cn/