隋森芳 博士
教授，博士生导师中科院院士
1964-1970 清华大学精密仪器系，学士
1978-1981 清华大学工程物理系，硕士
1985-1988 德国慕尼黑工业大学生物物理所，博士
1989-1991 清华大学生物科学与技术系，副教授
1991.1-至今 清华大学生命科学学院（2009年9月以前为生物科学与技术系），教授、博导
● 研究兴趣、领域：
我们利用冷冻电子显微学，结合生物化学、生物物理学和细胞生物学等技术手段，研究：
（1）蛋白质复合体及复杂蛋白质机器的结构、功能与工作机理；
（2）膜蛋白的结构、功能与工作机理；
（3）囊泡运输中的分子机制，蛋白质与膜脂的相互作用，生物膜与重大疾病的关系。
● 代表性论文：
- Zhang L, Wang X, Fan F, Wang HW, Wang J*, Li X*, Sui SF*. (2017) Cryo-EM structure of Nma111p, a unique HtrA protease composed of two protease domains and four PDZ domains. Cell Research, 27:582-585.
- Wang, X., Li, B., Guo, Y., Shen, S., Zhao, L., Zhang, P., Sun, Y., Sui, S.F.*, Deng, F.*, Lou, Z.* (2016) Molecular basis for the formation of ribonucleoprotein complex of Crimean-Congo hemorrhagic fever virus. J. Struct. Biol. 196, 455-465.
- Zhang, J., Pan, X., Yan, K., Sun, S., Gao, N.*, Sui, S.F.* (2015) Mechanisms of ribosome stalling by SecM at multiple elongation steps. Elife 4, pii: e09684.
- Hu, Z., Zhou, Q., Zhang, C., Fan, S., Cheng, W., Zhao, Y., Shao, F., Wang, H.W., Sui, S.F.*, Chai, J.* (2015). Structural and biochemical basis for induced self-propagation of NLRC4. Science 350, 399-404.
- Chang, L., Liu, X., Li, Y., Liu, C.C., Yang, F., Zhao, J.*, Sui, S.F.* (2015) Structural organization of an intact phycobilisome and its association with photosystem II. Cell Research 25, 726-737.
- Zhou, Q., Huang, X., Sun, S., Li, X., Wang, H.W.*, Sui, S.F.* (2015). Cryo-EM structure of SNAP-SNARE assembly in 20S particle. Cell Research 25, 551-560.
- Li, B., Wang, Q., Pan, X., Fernández de Castro I., Sun, Y., Guo, Y., Tao, X., Risco, C., Sui, S.F., Lou, Z.* (2013) Bunyamwera virus possesses a distinct nucleocapsid protein to facilitate genome encapsidation. Proc. Natl. Acad. Sci. U. S. A. 110, 9048-9053.
- Chang, L.F., Chen, S., Liu, C.C., Pan, X., Jiang, J., Bai, X.C., Xie, X., Wang, H.W., Sui, S.F.* (2012) Structural characterization of full-length NSF and 20S particles. Nat. Struct. Mol. Biol. 19, 268-275.
- Liu, L., Feng, D., Chen, G., Chen, M., Zheng, Q., Song, P., Ma, Q., Zhu, C., Wang, R., Qi, W., Huang, L., Xue, P., Li, B., Wang, X., Jin, H., Wang, J., Yang, F., Liu, P., Zhu, Y., Sui, S.F., Chen Q.* (2012) Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat. Cell Biol. 14, 177-185.
- Yang X, Yang F, Wang W, Lin G, Hu Z, Han Z, Qi Y, Zhang L, Wang J, Sui SF*, Chai J*. (2017) Structural basis for specific flagellin recognition by the NLR protein NAIP5. Cell Research, 28(1):35-47.
- Zhang J, Ma J, Liu D, Qin S, Sun S*, Zhao J, Sui SF*. (2017) Structure of phycobilisome from the red alga Griffithsia pacifica. Nature, 551:57-63.
- Sun S, Li L, Yang F, Wang X, Fan F, Yang M, Chen C, Li X, Wang HW, Sui SF*. (2017) Cryo-EM structures of the ATP-bound Vps4-E233Q hexamer and its complex with Vta1 at near-atomic resolution. Nat Commun., 8:16064.
● 联系方式：
电话：+86-10-62792083/62784768
E-mail: suisf@mail.tsinghua.edu.cn
Lab website: http://suilab.life.tsinghua.edu.cn/