王新泉 博士

教授, 博导

1990-1995, 复旦大学 学士

1995-2000, 中国科学院生物物理研究所 博士

2000-2003, 中国科学院生物物理研究所 助理研究员

2003-2008, 美国斯坦福大学 博士后

现任清华大学教授

 

● 研究兴趣、领域:

主要研究方向为结构生物学。利用X-射线晶体学为主要研究手段,结合其他生物化学及生物物理技术,研究细胞因子介导的宿主免疫反应和病毒侵染及免疫逃逸的结构机理。

 

● 代表性论文:

1.       Zuo T, Sun J, Wang G, Jiang L, Zuo Y, Li D, Shi X, Liu X, Fan S, Ren H, Hu H, Sun L, Zhou B, Liang M, Zhou P*, Wang X*, Zhang L*. Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection. Nature Communications 2015, 6:8855. doi: 10.1038/ncomms9855.

2.       Yu X, Zhang S, Jiang L, Cui Y, Li D, Wang D, Wang, N, Fu L, Shi X, Li Z, Zhang L*, Wang X*. Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27. Scientific Reports 2015, 5:13133. doi: 10.1038/srep13133.

3.       Wei H, Wang D, Qian Y, Liu X, Fan S, Yin H, Wang X*. Structural basis for the specific recognition of IL-18 by its alpha receptor. FEBS Letters 2014, 588 (21): 3838-3843.

4.       Jiang L, Wang N, Zuo T, Shi X, Poon KM, Wu Y, Gao F, Li D, Wang R, Guo J, Fu L, Yuen KY, Zheng BJ*, Wang X*, Zhang L*. Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein. Sci Transl Med. 2014, 6(234):234ra59. doi: 10.1126/scitranslmed.3008140.

5.       Mei K, Jin Z, Ren F, Wang Y, Chang Z*, Wang X*. Structural basis for the recognition of RNA polymerase II C-terminal domain by CREPT and p15RS. Sci China Life Sci 2014, 57: 97-106.

6.       Liu X, Hammel M, He Y, Tainer JA, Jeng US, Zhang L, Wang S*, Wang X*. Structural insights into the interaction of IL-33 with its receptors. Proc Natl Acad Sci USA. 2013, 110: 14918-23.

7.       Wang N, Shi X, Jiang L, Zhang S, Wang D, Tong P, Guo D, Fu L, Cui Y, Liu X, Arledge KC, Chen YH, Zhang L*, Wang X*. Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4. Cell Res. 2013, 23: 986-93.

8.       Wang D, Huang B, Zhang S, Yu X, Wu W, Wang X*. Structural basis for R-spondin recognition by LGR4/5/6 receptors. Genes Dev. 2013, 27: 1339-44.

9.       Liu X, Liu S, Feng Y, Liu J, Chen Y, Pham K, Deng H, Hirschi KD, Wang X*, Cheng NH*. (2013). Structural insights into the N-terminal GIY-YIG endonuclease activity of Arabidopsis glutaredoxin AtGRXS16 in chloroplasts. Proc. Nat. Acad. Sci. USA 110, 9565-9560.

10.     Wang X*. Structural studies of GDNF family ligands with their receptors-Insights into ligand recognition and activation of receptor tyrosine kinase RET. Biochim Biophys Acta. 2013, 1834: 2205-12.

11.     Luan X, Lu Q, Jiang Y, Zhang S, Wang Q, Yuan H, Zhao W, Wang J, Wang X*. Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin. J Immunol. 2012, 189: 245-252.

12.     Li L, Wang D, Jiang Y, Sun J, Zhang S, Chen Y, Wang X*. Crystal structure of human ISG15 in complex with influenza B virus NS1B. J Biol. Chem. 2011, 286: 30258-30262.

13.     Xue X, Lu Q, Wei H, Wang D, Chen D, He G, Huang L, Wang H, Wang X*. Structural Basis of Chemokine Sequestration by CrmD, a Poxvirus-Encoded Tumor Necrosis Factor Receptor. PLoS Pathog. 2011 Jul; 7(7):e1002162.

14.     Wang D, Zhang S, Li L, Liu X, Mei K, Wang X*. Structural insights into the assembly and activation of IL-1b with its receptors. Nat. Immunol. 2010, 11: 905-911.

15.     Gui M, W Song, H Zhou, J Xu, S Chen, Y Xiang*, and X Wang*. Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding. 2017, Cell Res. 27:119-129.

 

● 联系方式:

电话 +86-10-62789401              

E-mail: xinquanwang@mail.tsinghua.edu.cn